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Genomics, phytochemicals, and oxidative stress Sign in to save
Papers per year
Papers 31
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Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis2020 Journal of Hepatology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Antje Mohs, Tobias Otto, Kai Markus Schneider, Mona Peltzer, Mark V. Boekschoten, Christian H. Holland, +7 more
142citations -
Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression2024 Nature Communications article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Gloria Asantewaa, Emily T. Tuttle, Nathan P. Ward, Yun Pyo Kang, Yumi Kim, Madeline E. Kavanagh, +27 more
62citations -
Mining a human transcriptome database for chemical modulators of NRF22020 PLoS ONE article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
John P. Rooney, Brian N. Chorley, Steven W. Hiemstra, Steven Wink, Xuting Wang, Douglas A. Bell, +2 more
54citations -
Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure2022 Scientific Reports article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Steven W. Hiemstra, Mirjam Fehling-Kaschek, Isoude A. Kuijper, Luc J. M. Bischoff, Lukas S. Wijaya, Marcus Rosenblatt, +7 more
31citations -
Sulforaphane Exerts Beneficial Immunomodulatory Effects on Liver Tissue via a Nrf2 Pathway-Related Mechanism in a Murine Model of Hemorrhagic Shock and Resuscitation2022 Frontiers in Immunology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Weiqiang Liang, Johannes Greven, Kang Qin, Athanassios Fragoulis, Klemens Horst, Felix Bläsius, +5 more
19citations -
Novel Broccoli Sulforaphane-Based Analogues Inhibit the Progression of Pancreatic Cancer without Side Effects2020 Biomolecules article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Christina Georgikou, Laura Buglioni, Maximilian Bremerich, Nico C. Roubicek, Libo Yin, Wolfgang Groß, +3 more
19citations -
NRF2/Itaconate Axis Regulates Metabolism and Inflammatory Properties of T Cells in Children with JIA2022 Antioxidants article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Anandhi Rajendiran, Sudheendra Hebbar Subramanyam, Patricia Klemm, Vera Jankowski, Jorg van Loosdregt, Sebastiaan J. Vastert, +4 more
16citations -
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes2021 Cell Biology and Toxicology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Lukas S. Wijaya, Carina Rau, Theresa Braun, Serif Marangoz, Vincent Spegg, Matthijs Vlasveld, +8 more
15citations -
Nrf2 induces malignant transformation of hepatic progenitor cells by inducing β-catenin expression2022 Redox Biology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Athanassios Fragoulis, Julia Schenkel, Nicole Schröder, Elisa Fabiana Brandt, Mathias Weiand, Tabita Neu, +9 more
11citations -
Luteolin Induces Nrf2 Activity in C2C12 Cells: Implications for Muscle Health2025 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Frank Suhr, Thomas Pufe, Christoph Jan Wruck, Athanassios Fragoulis
9citations -
The Contribution of the Nrf2/ARE System to Mechanotransduction in Musculoskeletal and Periodontal Tissues2023 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Athanassios Fragoulis, Mersedeh Tohidnezhad, Yusuke Kubo, Christoph Jan Wruck, Rogerio Bastos Craveiro, Anna Bock, +4 more
9citations -
Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses2022 Toxicology in Vitro article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Bas ter Braak, Janna E. Klip, Steven Wink, Steven W. Hiemstra, Sarah Lucy Cooper, A. Middleton, +2 more
8citations -
Sulforaphane regulates hepatic autophagy and apoptosis by modulating Kupffer cells’ polarization via Nrf2/HO-1 pathway in the murine hemorrhagic shock/resuscitation model2025 European Journal of Trauma and Emergency Surgery article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress
Athanassios Fragoulis, Weining Yan, Xing Zhang, Qun Zhao, Chunxia Ma, Zhizhen He, +3 more
4citations -
Pharmacological effects of methysticin and L-sulforaphane through the Nrf2/ARE signaling pathway in MLO-Y4 osteocytes: in vitro study2024 Annals of Anatomy - Anatomischer Anzeiger article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Maja Charlotte Dittmar, Mersedeh Tohidnezhad, Athanassios Fragoulis, Annette Bücker, M. Stein, Thomas Pufe, +1 more
3citations -
Computational modelling identifies primary mediators of crosstalk between DNA damage and oxidative stress responses2025 PLoS Computational Biology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Elsje J Burgers, Raju P. Sharma, Carl Joshua Eugenio, Muriel M. Heldring, Lukas S. Wijaya, Bob van de Water, +1 more
3citations -
Platelet‐Released Growth Factors (PRGFs) Activate NRF2‐ARE and Modulate Inflammatory Response in an NRF2‐Dependent Manner in Primary Human Keratinocytes2025 Journal of Cosmetic Dermatology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Mersedeh Tohidnezhad, Athanassios Fragoulis, Andreas U. Bayer, Hannes Klump, Jens Malte Baron, Thomas Pufe
2citations
Most active Aachen authors
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Athanassios Fragoulis 2,355 citations overall10 papers
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Bob van de Water 13,491 citations overall7 papers
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Thomas Pufe 9,376 citations overall7 papers
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Christoph Jan Wruck 4,664 citations overall5 papers
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Joost B. Beltman 4,098 citations overall5 papers
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Christian Trautwein 60,353 citations overall4 papers
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Antje Mohs 1,595 citations overall4 papers
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Mersedeh Tohidnezhad 1,656 citations overall3 papers
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Bas ter Braak 614 citations overall3 papers
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Steven W. Hiemstra 447 citations overall3 papers
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Lukas S. Wijaya 305 citations overall3 papers
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Julio Sáez-Rodríguez 48,113 citations overall2 papers
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Tobias Otto 4,189 citations overall2 papers
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Steven Wink 881 citations overall2 papers
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Johannes Greven 803 citations overall2 papers