QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation

CPT Pharmacometrics & Systems Pharmacology, vol. 12, pp. 889–903

Abstract

Typical Quantitative Systems Pharmacology (QSP) workflows involve discussion of biology, supported by graphical diagrams, followed by construction of large Ordinary Differential Equation models. QSP Designer facilitates this process by providing enhanced graphical notation, which enables hierarchical presentation with modules and handling of combinatorial complexity with diagram node arrays. Whereas the software includes a simulation engine, a major feature is full model code generation in MATLAB, R, C, and Julia to support multiple modeling communities.

Authors 3

1. David M. Hollinshead
   Affiliation as printed

   Certara UK Sheffield UK

   Certara UK, Sheffield, UK

2. Piet H. van der Graaf Aachen Leiden Academic Centre for Drug Research

   Leiden University

   Affiliation as printed

   Certara UK Sheffield UK

   Leiden Academic Centre for Drug Research Universiteit Leiden Leiden the Netherlands

   Certara UK, Sheffield, UK

   Leiden Academic Centre for Drug Research, Universiteit Leiden, Leiden, the Netherlands

3. Andrzej M. Kierzek corresponding

   University of Surrey

   Affiliation as printed

   Certara UK Sheffield UK

   School of Biosciences and Medicine University of Surrey Guildford UK

   Certara UK, Sheffield, UK

   School of Biosciences and Medicine, University of Surrey, Guildford, UK