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Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase2024 The Journal of Cell Biology article Biochemistry, Genetics and Molecular Biology Microtubule and mitosis dynamics Open access
Gabriella S. Darmasaputra, Cindy C. Geerlings, Susana M. Chuva de Sousa Lopes, Hans C. Clevers, Matilde Galli
15citations -
Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes2021 Toxicology in Vitro article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Bas ter Braak, Marije Niemeijer, Ruben Boon, Celine Parmentier, Audrey Baze, Lysiane Richert, +4 more
14citations -
Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors2024 Environmental Health Perspectives article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Marije Niemeijer, Witold Więcek, Shuai Fu, Suzanna Huppelschoten, Peter Bouwman, Audrey Baze, +5 more
16citations -
Discrimination of Steatotic and Non-Steatotic Chemicals Through Transcriptome Analysis in Primary Human Hepatocytes2026 International Journal of Molecular Sciences article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Christina A. Cramer von Clausbruch, Marcha C. T. Verheijen, Giulia Callegaro, Jonathan H. Freedman, Rita Ortega-Vallbona, Martina Palomino‐Schätzlein, +2 more
1citations -
MicroRNAs modulate SARS ‐ CoV ‐2 infection of primary human hepatocytes by regulating the entry factors ACE2 and TMPRSS22024 Liver International article Biochemistry, Genetics and Molecular Biology MicroRNA in disease regulation Open access
Rajendra Khanal, Natalie Heinen, Alexandra Bogomolova, Toni Luise Meister, Simon T. Herrmann, Saskia Westhoven, +11 more
4citations -
Transcriptomic profiling of the inter-individual variability of chemical-induced cellular stress response activation in primary human hepatocytes2021 Toxicology Letters article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection
Marije Niemeijer, Witold Więcek, S. Huppelschoten, Audrey Baze, Celine Parmentier, Lysiane Richert, +3 more
0citations -
Evaluation of in vitro liver models and non-human primates for predicting ADAR RNA editing efficiency in human liver2025 Scientific Reports article Biochemistry, Genetics and Molecular Biology RNA regulation and disease Open access
Mònica Aguilà, Nicole H.P. Cnubben, David A. Parfitt, Bruno Albuquerque, Peter C. de Visser, Marlieke Molendijk, +1 more
0citations -
Comparing in vitro human liver models to in vivo human liver using RNA-Seq2020 Archives of Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access cited by 1 patent
Yannick Schrooders, Duncan A. Hauser, Marcel van Herwijnen, Wiebke Albrecht, Bas ter Braak, Tim Brecklinghaus, +17 more
100citations -
A comparison between different human hepatocyte models reveals profound differences in net glucose production, lipid composition and metabolism in vitro2024 Experimental Cell Research article Biochemistry, Genetics and Molecular Biology Metabolism, Diabetes, and Cancer Open access
Flavio Bonanini, Madhulika Singh, Hong Yang, Dorota Kurek, Amy C. Harms, Adil Mardinoğlu, +1 more
12citations -
The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment2021 Archives of Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Giulia Callegaro, Steven J. Kunnen, Panuwat Trairatphisan, Solène Grosdidier, Marije Niemeijer, Wouter den Hollander, +9 more
43citations -
Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models2025 Toxicology in Vitro article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Tamara Meijer, Bas ter Braak, Liesanne Wolters, Steven J. Kunnen, Barira Islam, Ilinca Suciu, +8 more
3citations -
Utility of Extrapolating Human S1500+ Genes to the Whole Transcriptome: Tunicamycin Case Study2020 Bioinformatics and Biology Insights article Biochemistry, Genetics and Molecular Biology Gene expression and cancer classification Open access
Deepak Mav, Dhiral P. Phadke, Michele R. Balik-Meisner, Bruce Alex Merrick, Scott S. Auerbach, Marije Niemeijer, +7 more
10citations -
Mining a human transcriptome database for chemical modulators of NRF22020 PLoS ONE article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
John P. Rooney, Brian N. Chorley, Steven W. Hiemstra, Steven Wink, Xuting Wang, Douglas A. Bell, +2 more
54citations -
Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses2022 Toxicology in Vitro article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Bas ter Braak, Janna E. Klip, Steven Wink, Steven W. Hiemstra, Sarah Lucy Cooper, A. Middleton, +2 more
8citations -
Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids
Samantha V. Llewellyn, Ali Kermanizadeh, Victor Chibueze Ude, Nicklas Raun Jacobsen, Gillian E. Conway, Ume-Kulsoom Shah, +8 more
11citations -
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes2021 Cell Biology and Toxicology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Lukas S. Wijaya, Carina Rau, Theresa Braun, Serif Marangoz, Vincent Spegg, Matthijs Vlasveld, +8 more
15citations