Quantitative High Content Imaging of Cellular Adaptive Stress Response Pathways in Toxicity for Chemical Safety Assessment

• Imaging-based temporal dynamics of electrophile-induced NRF2 signaling in liver cells identifies adaptive versus adverse repeated exposure conditions

  2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress

  1

  citations
• Mechanism-based drug safety testing using innovative in vitro liver models: from DILI prediction to idiosyncratic DILI liability assessment

  2025 Expert Opinion on Drug Metabolism & Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  3

  citations
• The integrated stress response‐related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability

  2024 Liver International article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  7

  citations
• A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury

  2023 Toxicological Sciences article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  13

  citations
• Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells

  2023 Journal of Chemical Information and Modeling article Computer Science Computational Drug Discovery Methods Open access

  3

  citations
• Differential response of luminal and basal breast cancer cells to acute and chronic hypoxia

  2023 Breast Cancer Research and Treatment article Biochemistry, Genetics and Molecular Biology Cancer, Hypoxia, and Metabolism Open access

  2

  citations
• Identifying multiscale translational safety biomarkers using a network-based systems approach

  2023 iScience article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  14

  citations
• A Network-based Transcriptomic Landscape of HepG2 cells to Uncover Causal Gene Cytotoxicity Interactions Underlying Drug-Induced Liver Injury

  2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  1

  citations
• Model-based translation of DNA damage signaling dynamics across cell types

  2022 PLoS Computational Biology article Medicine Cancer-related Molecular Pathways Open access

  12

  citations
• Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses

  2022 Toxicology in Vitro article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access

  8

  citations
• Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure

  2022 Scientific Reports article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access

  31

  citations
• Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

  2022 ALTEX article Veterinary Animal testing and alternatives Open access

  64

  citations
• Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

  2021 Archives of Toxicology article Biochemistry, Genetics and Molecular Biology Mitochondrial Function and Pathology Open access

  18

  citations
• The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment

  2021 Archives of Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  43

  citations
• Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages

  2021 Archives of Toxicology article Biochemistry, Genetics and Molecular Biology Heme Oxygenase-1 and Carbon Monoxide Open access

  23

  citations
• Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters

  2021 Mutagenesis article Biochemistry, Genetics and Molecular Biology Carcinogens and Genotoxicity Assessment Open access

  6

  citations
• Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes

  2021 Cell Biology and Toxicology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access

  15

  citations
• The human hepatocyte TXG-MAPr: WGCNA transcriptomic modules to support mechanism-based risk assessment

  2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  1

  citations
• Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury

  2021 Biochemical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  27

  citations
• Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes

  2021 Toxicology in Vitro article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  14

  citations

20 results