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Protein purification and stability Sign in to save
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Papers 53
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Oxidation and Deamidation of Monoclonal Antibody Products: Potential Impact on Stability, Biological Activity, and Efficacy2021 Journal of Pharmaceutical Sciences article Biochemistry, Genetics and Molecular Biology Protein purification and stability cited by 3 patents
Surbhi Gupta, Wim Jiskoot, Christian Schöneich, Anurag Singh Rathore
155citations -
The use of predictive models to develop chromatography-based purification processes2022 Frontiers in Bioengineering and Biotechnology article Biochemistry, Genetics and Molecular Biology Protein purification and stability Open access
C. R. Bernau, Matthias Knödler, Jessica Emonts, Ronald Jäpel, Johannes F. Buyel
51citations -
Particles in Biopharmaceutical Formulations, Part 2: An Update on Analytical Techniques and Applications for Therapeutic Proteins, Viruses, Vaccines and Cells2021 Journal of Pharmaceutical Sciences article Biochemistry, Genetics and Molecular Biology Protein purification and stability Open access
Alexandra Roesch, Sarah Zölls, Daniela Stadler, Constanze Helbig, Klaus Wuchner, Gideon F. A. Kersten, +3 more
43citations -
Rapid aggregation of therapeutic monoclonal antibodies by bubbling induced air/liquid interfacial and agitation stress at different conditions38citations
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Stress Factors in Primary Packaging, Transportation and Handling of Protein Drug Products and Their Impact on Product Quality2022 Journal of Pharmaceutical Sciences article Biochemistry, Genetics and Molecular Biology Protein purification and stability
Linda Owers Narhi, Danny K. Chou, Twinkle R. Christian, Bharat Jagannathan, Wim Jiskoot, Susan L. P. Jordan, +3 more
34citations -
Stress Factors in Protein Drug Product Manufacturing and Their Impact on Product Quality2021 Journal of Pharmaceutical Sciences article Biochemistry, Genetics and Molecular Biology Protein purification and stability
Tapan Kanti Das, Alavattam Sreedhara, James D. Colandene, Danny K. Chou, Vasco Filipe, Christoph Grapentin, +4 more
33citations -
In vitro and in vivo immunogenicity assessment of protein aggregate characteristics2022 International Journal of Pharmaceutics article Biochemistry, Genetics and Molecular Biology Protein purification and stability Open access
Camilla Thorlaksen, Heidi Schiøler Schultz, Simon K. Gammelgaard, Wim Jiskoot, Nikos S. Hatzakis, Flemming Seier Nielsen, +4 more
27citations -
Fast analysis of antibody-derived therapeutics by automated multidimensional liquid chromatography – Mass spectrometry2021 Analytica Chimica Acta article Biochemistry, Genetics and Molecular Biology Protein purification and stability Open access
Sanne Pot, Christoph Gstöttner, Katrin Heinrich, Sina Hoelterhoff, Ingrid Grunert, Michael Leiß, +2 more
27citations -
Detailed small-scale characterization and scale-up of active YFP inclusion body production with Escherichia coli induced by a tetrameric coiled coil domain2020 Journal of Bioscience and Bioengineering article Biochemistry, Genetics and Molecular Biology Protein purification and stability
Robin Lamm, Vera D. Jäger, Benedikt Heyman, Christoph Berg, Christin Cürten, Ulrich Krauß, +2 more
18citations -
Modeling hindered diffusion of antibodies in agarose beads considering pore size reduction due to adsorption2020 Journal of Chromatography A article Biochemistry, Genetics and Molecular Biology Protein purification and stability
Franziska Hagemann, Patrick Adametz, Matthias Weßling, Volkmar Thom
18citations -
Comprehensive Multidimensional Liquid Chromatography–Mass Spectrometry for the Characterization of Charge Variants of a Bispecific Antibody2022 Journal of the American Society for Mass Spectrometry article Biochemistry, Genetics and Molecular Biology Protein purification and stability Open access
Ingrid Grunert, Katrin Heinrich, Michael Hingar, Juliane Ernst, Katrin Bomans, Arnaud Fevre, +3 more
18citations -
Integration of a perfusion reactor and continuous precipitation in an entirely membrane‐based process for antibody capture2023 Engineering in Life Sciences article Biochemistry, Genetics and Molecular Biology Protein purification and stability Open access
Gabriele Recanati, Magdalena Pappenreiter, Christoph Gstoettner, Patrick Scheidl, Elena Domínguez‐Vega, Bernhard Sissolak, +1 more
18citations -
Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability2022 ACS Omega article Biochemistry, Genetics and Molecular Biology Protein purification and stability Open access cited by 4 patents
Ingrid Grunert, Katrin Heinrich, Juliane Ernst, Michael Hingar, Alexandre Briguet, Michael Leiß, +3 more
17citations -
High-throughput screening of catalytically active inclusion bodies using laboratory automation and Bayesian optimization2024 Microbial Cell Factories article Biochemistry, Genetics and Molecular Biology Protein purification and stability Open access
Laura M. Helleckes, Kira Küsters, Rebecca Hamel, Ronja Saborowski, Jan Marienhagen, Wolfgang Wiechert, +1 more
16citations -
Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S2020 Scientific Reports article Biochemistry, Genetics and Molecular Biology Protein purification and stability Open access cited by 1 patent
Thomas J. M. Michiels, Hugo D. Meiring, Wim Jiskoot, Gideon F. A. Kersten, Bernard Metz
15citations -
Precision analysis for the determination of steric mass action parameters using eight tobacco host cell proteins2021 Journal of Chromatography A article Biochemistry, Genetics and Molecular Biology Protein purification and stability Open access
C. R. Bernau, Ronald Jäpel, Jan Hübbers, Patrick Opdensteinen, Johannes F. Buyel
13citations -
Impact of Stress on the Immunogenic Potential of Adalimumab2023 Journal of Pharmaceutical Sciences article Biochemistry, Genetics and Molecular Biology Protein purification and stability
Petteri Heljo, Maryam Ahmadi, Malthe Møhl Schack, Anaïs Manin, Per Franklin Nielsen, Xinsheng Tian, +4 more
11citations
Most active Aachen authors
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Wim Jiskoot 29,701 citations overall19 papers
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Johannes F. Buyel 3,723 citations overall5 papers
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Gideon F. A. Kersten 8,506 citations overall4 papers
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Manfred Wuhrer 32,864 citations overall3 papers
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Stefan G. Romeijn 4,366 citations overall3 papers
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Eric von Lieres 3,371 citations overall3 papers
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Andreas Jupke 2,519 citations overall3 papers
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G. Philip Wiese 55 citations overall3 papers
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Thomas Fuchs 44 citations overall3 papers
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Elena Domínguez‐Vega 2,111 citations overall2 papers
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Matthias Knödler 1,668 citations overall2 papers
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Christoph Gstöttner 532 citations overall2 papers
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Patrick Opdensteinen 507 citations overall2 papers
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Adam Grabarek 240 citations overall2 papers
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Thomas J. M. Michiels 149 citations overall2 papers