Papers matching “small molecule modulators” 71
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Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death2021 Computational and Structural Biotechnology Journal article Neuroscience Genetic Neurodegenerative Diseases Open access
Michael A. Margreiter, Monika Witzenberger, Yasmine Wasser, Elena Davydova, Robert Janowski, Jonas Metz, +12 more
19citations -
Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Genetic Neurodegenerative Diseases Open access
Michael A. Margreiter, Monika Witzenberger, Yasmine Wasser, Elena Davydova, Robert Janowski, Carina Sobisch, +11 more
0citations -
A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology interferon and immune responses Open access
Sandra Hess, Marta Campos Alonso, Michael J. D. Brand, Susan Lauw, Urs Lindenmann, Paul P. Geurink, +3 more
6citations -
Identification of small-molecule enhancers of circadian rhythm amplitude in central and peripheral clocks2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Circadian rhythm and melatonin Open access
Maitreyi S. Joshi, Felix Albert, Johanna H. Meijer, Stephan H. Michel, Paul P. Geurink
0citations -
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes2022 Stem Cell Reports article Immunology and Microbiology Complement system in diseases Open access
Francesca A. Rapino, Ted E. Natoli, Francesco Limone, Jack Blank, Matthew Tegtmeyer, William C. Chen, +16 more
19citations -
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells2020 Proceedings of the National Academy of Sciences article Computer Science Computational Drug Discovery Methods Open access
Matthias Barone, Slim Chiha, Jiang Ren, Dominik Albat, Arne Soicke, Stephan Dohmen, +16 more
38citations -
A PIKfyve modulator combined with an integrated stress response inhibitor to treat lysosomal storage diseases2024 Proceedings of the National Academy of Sciences article Medicine Lysosomal Storage Disorders Research Open access
William C. Hou, Lynée A. Massey, Derek J. Rhoades, Yin Wu, Wen Ren, Chiara Frank, +2 more
12citations -
A Pro‐Fluorescent Ubiquitin‐Based Probe to Monitor Cysteine‐Based E3 Ligase Activity2023 Angewandte Chemie article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access
David A. Pérez Berrocal, Thimmalapura M. Vishwanatha, Daniel Horn‐Ghetko, J. Josephine Botsch, Laura A. Hehl, Sebastian Kostrhon, +6 more
0citations -
Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery2025 Nature Reviews Drug Discovery review Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Paolo Conflitti, Edward R. Lyman, Mark S.P. Sansom, Peter Werner Hildebrand, Hugo Gutiérrez‐de‐Terán, Paolo Carloni, +10 more
86citations -
Development and application of a high-content biology-based assay to quantify effects of modulators of NETosis in primary human neutrophils2023 The Journal of Immunology conference-abstract Immunology and Microbiology Neutrophil, Myeloperoxidase and Oxidative Mechanisms Open access
C JM Loomans, Xin-Xuan Lin, Rocco Sciarrillo, Lisa Scandiuzzi, Jan Stallen, Fabian Stavenuiter, +1 more
0citations -
Autophagy is responsible for the accumulation of proteogenic dipeptides in response to heat stress in Arabidopsis thaliana2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Autophagy in Disease and Therapy Open access
Venkatesh P. Thirumalaikumar, Mateusz Maciej Wagner, Salma Balazadeh, Aleksandra Skirycz
5citations -
oborel/obo-relations: September 2026 Release2026 Zenodo (CERN European Organization for Nuclear Research) software Biochemistry, Genetics and Molecular Biology Biomedical Text Mining and Ontologies Open access
Chris J Mungall, Nicolas Matentzoglu, Jim Balhoff, David Osumi-Sutherland, Bill Duncan, pgaudet, +23 more
0citations -
A Pro‐Fluorescent Ubiquitin‐Based Probe to Monitor Cysteine‐Based E3 Ligase Activity2023 Angewandte Chemie International Edition article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access
David A. Pérez Berrocal, Thimmalapura M. Vishwanatha, Daniel Horn‐Ghetko, J. Josephine Botsch, Laura A. Hehl, Sebastian Kostrhon, +6 more
4citations -
Development and Validation of a High‐Throughput Screening Assay for the Legionella ADP‐Ribosyl Transferase SdeA2025 ChemBioChem article Biochemistry, Genetics and Molecular Biology Legionella and Acanthamoeba research Open access
Halana C. Vlaming, Vito Pol, Bjorn R. van Doodewaerd, Angeliki Moutsiopoulou, Paul P. Geurink, Robbert Q. Kim, +1 more
1citations -
Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor2023 Molecular Pharmacology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Vi Pham, Maria Clazina Cornelia Habben Jansen, Geoff V. Thompson, Laura H. Heitman, Arthur Christopoulos, David M. Thal, +1 more
6citations -
FERMO: a Dashboard for Automated Prioritization of Molecular Features from Mass Spectral Data2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Metabolomics and Mass Spectrometry Studies Open access
Mitja M. Zdouc, Hannah E. Augustijn, Nataliia V. Machushynets, Lina M. Bayona, Sylvia Soldatou, Niek De Jonge, +5 more
17citations