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Receptor Mechanisms and Signaling Sign in to save
Papers per year
Papers 68
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors2021 British Journal of Pharmacology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
S P H Alexander, Arthur Christopoulos, Anthony P. Davenport, Eamonn Kelly, Alistair A. Mathie, John A. Peters, +94 more
487citations -
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors2023 British Journal of Pharmacology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
S P H Alexander, Arthur Christopoulos, Anthony P. Davenport, Eamonn Kelly, Alistair A. Mathie, John A. Peters, +94 more
395citations -
Ultrafast structural changes direct the first molecular events of vision2023 Nature article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Thomas Gruhl, Tobias Weinert, Matthew J. Rodrigues, Christopher Jackson Milne, Giorgia Ortolani, Karol Nass, +43 more
134citations -
Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery2025 Nature Reviews Drug Discovery review Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Paolo Conflitti, Edward R. Lyman, Mark S.P. Sansom, Peter Werner Hildebrand, Hugo Gutiérrez‐de‐Terán, Paolo Carloni, +10 more
88citations -
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways2025 Nature Communications article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
David Aranda-García, Tomasz Maciej Stępniewski, Mariona Torrens‐Fontanals, Adrián García‐Recio, Marta Lopez‐Balastegui, Brian Medel-Lacruz, +36 more
68citations -
Perspective: Implications of Ligand–Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors2020 ACS Pharmacology & Translational Science article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Wijnand J. C. van der Velden, Laura H. Heitman, METTE MARIE ROSENKILDE
67citations -
Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K12023 Journal of Chemical Information and Modeling article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Alessandro Nicoli, Franziska Haag, Patrick Marcinek, Ruiming He, Johanna Kreißl, Jörg Stein, +5 more
30citations -
Structural insight into selectivity of amylin and calcitonin receptor agonists2023 Nature Chemical Biology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling cited by 2 patents
Jianjun Cao, Matthew J. Belousoff, Elliot J. Gerrard, Radostin Danev, Madeleine M. Fletcher, Emma Dal Maso, +8 more
19citations -
Revisit ligand-receptor interaction at the human vasopressin V2 receptor: A kinetic perspective2020 European Journal of Pharmacology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling
Leyi Xia, Kequan Fu, Xudong Cao, Wenzhong Yan, Jianjun Cheng, Thomas Roux, +3 more
18citations -
A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery2021 Scientific Reports article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Hubert J. Sijben, Julie J. E. van den Berg, Jeremy D. Broekhuis, Adriaan P. IJzerman, Laura H. Heitman
16citations -
Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs2024 British Journal of Pharmacology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Éva Bertalan, Matthew J. Rodrigues, Gebhard F. X. Schertler, Ana‐Nicoleta Bondar
14citations -
A Chemical Biological Approach to Study G Protein-Coupled Receptors: Labeling the Adenosine A1 Receptor Using an Electrophilic Covalent Probe2022 ACS Chemical Biology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Bert L. H. Beerkens, Çağla Koç, Rongfang Liu, Bogdan I. Florea, Sylvia E. Le Dévédec, Laura H. Heitman, +2 more
14citations -
Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors2021 Scientific Reports article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Hubert J. Sijben, Wieke M. van Oostveen, Peter B. R. Hartog, Laura Stucchi, Andrea Rossignoli, Lia Scarabottolo, +2 more
13citations -
Cardiac and Vascular α1-Adrenoceptors in Congestive Heart Failure: A Systematic Review2020 Cells review Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Gizem Kayki‐Mutlu, Olga Papazisi, Meindert Palmen, A.H. Jan Danser, Martin Christian Michel, Ebru Arioglu‐Inan
13citations -
G protein-coupled receptors expressed and studied in yeast. The adenosine receptor as a prime example2020 Biochemical Pharmacology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access cited by 1 patent
Xuesong Wang, Gerard J. P. van Westen, Laura H. Heitman, Adriaan P. IJzerman
12citations -
Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism2022 Biochemical Pharmacology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Lisa S. den Hollander, Olivier J. M. Béquignon, Xiangzi Wang, K. van Wezel, Jeremy D. Broekhuis, Marina Gorostiola González, +4 more
10citations -
N-Acyl-N-Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A2B Receptor as Case Study2024 ACS Chemical Biology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Bert L. H. Beerkens, Vasiliki Andrianopoulou, Xuesong Wang, Rongfang Liu, Gerard J. P. van Westen, Willem Jespers, +3 more
10citations -
Deciphering conformational selectivity in the A2A adenosine G protein-coupled receptor by free energy simulations2021 PLoS Computational Biology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Willem Jespers, Laura H. Heitman, Adriaan P. IJzerman, Eddy Sotelo, Gerard J. P. van Westen, Johan Åqvist, +1 more
9citations
Most active Aachen authors
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Laura H. Heitman 7,065 citations overall22 papers
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Adriaan P. IJzerman 28,835 citations overall20 papers
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Gerard J. P. van Westen 6,624 citations overall11 papers
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Giulia Rossetti 3,028 citations overall8 papers
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Willem Jespers 1,899 citations overall7 papers
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Lisa S. den Hollander 48 citations overall6 papers
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Paolo Carloni 15,200 citations overall5 papers
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Daan van der Es 508 citations overall4 papers
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Olivier J. M. Béquignon 272 citations overall4 papers
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Alessandro Marchetto 183 citations overall4 papers
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Bert L. H. Beerkens 179 citations overall4 papers
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Erik H.J. Danen 9,611 citations overall3 papers
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Xuesong Wang 6,908 citations overall3 papers
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Rongfang Liu 2,199 citations overall3 papers
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Marina Gorostiola González 634 citations overall3 papers