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Do Brain Extracellular Fluid Concentrations Predict PET ‐Inferred Receptor Occupancy in Human CNS ? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands2026 Clinical Pharmacology & Therapeutics article Neuroscience Neurotransmitter Receptor Influence on Behavior Open access
Divakar Budda, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
0citations -
Beta-endorphin is the key endogenous opioid influencing morphine µ-opioid receptor occupancy in rat hypothalamus: a binding kinetic model analysis2025 European Journal of Pharmaceutical Sciences article Neuroscience Neuropeptides and Animal Physiology Open access
Divakar Budda, Zhicheng Zhang, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
5citations -
The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D 2 receptor occupancy in humans2026 British Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Mengxu Zhang, Thomas I.F.H. Cremers, Vivi Rottschäfer, Elizabeth C. M. de Lange
0citations -
Revisit ligand-receptor interaction at the human vasopressin V2 receptor: A kinetic perspective2020 European Journal of Pharmacology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling
Leyi Xia, Kequan Fu, Xudong Cao, Wenzhong Yan, Jianjun Cheng, Thomas Roux, +3 more
18citations -
Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial2020 Journal of Psychopharmacology article Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling
Kasper Recourt, Jasper van der Aart, Gabriël E. Jacobs, Marieke de Kam, Wayne Curtis Drevets, Luc Van Nueten, +7 more
61citations -
Mechanism of Calcium Permeation in a Glutamate Receptor Ion Channel2023 Journal of Chemical Information and Modeling article Neuroscience Neuroscience and Neuropharmacology Research Open access
Florian Karl Schackert, Johann Biedermann, Saeid Abdolvand, Sonja Minniberger, Chen Song, Andrew J.R. Plested, +2 more
24citations -
Safety, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary efficacy of AZD2936, a bispecific antibody targeting PD-1 and TIGIT, in checkpoint inhibitor (CPI)-experienced advanced/metastatic non-small-cell lung cancer (NSCLC): First report of ARTEMIDE-01.2023 Journal of Clinical Oncology conference-abstract Medicine Cancer Immunotherapy and Biomarkers Open access
Kristoffer Staal Rohrberg, Mariana Brandão, Eduardo Castañón Álvarez, Enriqueta Felip, Eelke Hiddo Gort, T. Jeroen N. Hiltermann, +14 more
22citations -
Optimisation of pharmacotherapy in psychiatry through therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests: Focus on antipsychotics2024 The World Journal of Biological Psychiatry article Medicine Schizophrenia research and treatment Open access
Xenia Marlene Hart, Gerhard Gründer, Nicolas Ansermot, Andreas Conca, Emmanuelle Corruble, Séverine Crettol, +28 more
38citations -
Single dose tocilizumab for COVID‐19 associated cytokine storm syndrome: Less is more2023 British Journal of Clinical Pharmacology article Medicine COVID-19 Clinical Research Studies Open access
Niels W. Boone, Dirk Jan A. R. Moes, Sofía Ramiro, Rémy L.M. Mostard, César Magro Checa, Christel M. P. van Dongen, +6 more
4citations -
Effect of Acute Hypoxia Exposure on the Availability of A1Adenosine Receptors and Perfusion in the Human Brain2024 Journal of Nuclear Medicine article Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling Open access
Manuel Michno, Jan Schmitz, Anna L. Foerges, Simone Beer, Bernd Neumaier, Alexander E. Drzezga, +6 more
2citations -
OC07.03: Nipocalimab pharmacodynamics in a phase 2 study in pregnancies at risk of early‐onset severe hemolytic disease of the fetus and newborn2023 Ultrasound in Obstetrics and Gynecology conference-abstract Medicine Blood groups and transfusion cited by 2 patents
L. E. Ling, Jocelyn H. Leu, Masja de Haas, May Lee Tjoa, Shumyla Saeed-Khawaja, Eleonor Tiblad, +4 more
0citations -
monarch-initiative/mondo: v2026-07-062026 Zenodo (CERN European Organization for Nuclear Research) software Biochemistry, Genetics and Molecular Biology Biomedical Text Mining and Ontologies Open access
Nicole Vasilevsky, Chris J Mungall, Nicolas Matentzoglu, Sabrina Toro, Trish Whetzel, MeeSiing Ngu, +20 more
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