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Maximizing Heterologous Expression of Engineered Type I Polyketide Synthases: Investigating Codon Optimization Strategies2023 ACS Synthetic Biology article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Matthias Schmidt, Namil Lee, Chunjun Zhan, Jacob B. Roberts, Alberto A. Nava, Leah S. Keiser, +6 more
43citations -
Maximizing Heterologous Expression of Engineered Type I Polyketide Synthases: Investigating Codon Optimization Strategies2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Microbial Natural Products and Biosynthesis Open access
Matthias Schmidt, Namil Lee, Chunjun Zhan, Jacob B. Roberts, Alberto A. Nava, Leah S. Keiser, +6 more
4citations -
Optimization of a T7 RNA polymerase expression system for high-yield protein production in Cupriavidus necator H162025 RWTH Publications (RWTH Aachen) article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Matteo Vajente, Hendrik Ballerstedt, Lars M. Blank, Sandy Schmidt
0citations -
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease2023 Journal of Medicinal Chemistry article Neuroscience Genetic Neurodegenerative Diseases Open access
Longbin Liu, Karine Malagu, Alan F. Haughan, Vinod K. Khetarpal, Andrew J. Stott, William Esmieu, +41 more
8citations -
Intronization enhances expression of S-protein and other transgenes challenged by cryptic splicing2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology RNA Research and Splicing Open access
Kärt Tomberg, Liliana Antunes, Yangyang Pan, Jacob Hepkema, Dimitrios A. Garyfallos, Ahmed Essam Mahfouz, +1 more
1citations -
Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID2020 Molecular Therapy — Methods & Clinical Development article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access
Laura García-Pérez, Marja C.J.A. van Eggermond, Lieke van Roon, Sandra A. Vloemans, Martijn Cordes, Axel Schambach, +16 more
58citations -
High-yield protein production in the chemolithoautotrophic bacterium Cupriavidus necator H162025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Matteo Vajente, Hendrik Ballerstedt, Lars M. Blank, Sandy Schmidt
0citations -
The C-Terminal Domain of Clostridioides difficile TcdC Is Exposed on the Bacterial Cell Surface2020 Journal of Bacteriology article Medicine Clostridium difficile and Clostridium perfringens research Open access
Ana M. Oliveira Paiva, Leen de Jong, Annemieke H. Friggen, Wiep Klaas Smits, Jeroen Corver
25citations -
Optimizing interleukin-6 and 8 expression, clarification and purification in plant cell packs and plants for application in advanced therapy medicinal products and cellular agriculture11citations
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Restoration of T and B Cell Differentiation after RAG1 Gene Transfer in Human RAG1 Defective Hematopoietic Stem Cells2024 Biomedicines article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access
Nataël Sorel, Francisco Díaz-Pascual, Boris Bessot, Hanem Sadek, Chloé Mollet, Myriam Chouteau, +12 more
5citations -
Evolution of Hominin Detoxification: Neanderthal and Modern Human Ah Receptor Respond Similarly to TCDD2020 Molecular Biology and Evolution article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Jac M. M. J. G. Aarts, Gerrit M. Alink, Henk Franssen, Wil Roebroeks
8citations -
A single-nucleotide change in the Kozak sequence enhances protein expression2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology RNA and protein synthesis mechanisms Open access
Renzo A. Knol, Tahmina Fariaby, Eveline A. de Vlieger, Alexander Kros, Bram Slütter
0citations -
CRISPR/Cas with ribonucleoprotein complexes and transiently selected telomere vectors allows highly efficient marker-free and multiple genome editing in Botrytis cinerea2020 PLoS Pathogens article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 1 patent
Thomas Leisen, Fabian Bietz, J.A. Werner, Alex Wegner, Ulrich Schaffrath, David Scheuring, +4 more
128citations -
CRISPR/Cas with ribonucleoprotein complexes and transiently selected telomere vectors allows highly efficient marker-free and multiple genome editing in Botrytis cinerea2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Thomas Leisen, Fabian Bietz, Alex Wegner, Ulrich Schaffrath, David Scheuring, Felix Willmund, +3 more
18citations -
Improving stool sample processing and pyrosequencing for quantifying benzimidazole resistance alleles in Trichuris trichiura and Necator americanus pooled eggs2021 Parasites & Vectors article Immunology and Microbiology Parasites and Host Interactions Open access
Javier Gandasegui, Berta Grau-Pujol, María Cambra-Pellejà, Valdemiro Escola, Maria Antonietta Demontis, Anélsio Cossa, +5 more
8citations -
Correction of pathology in mice displaying Gaucher disease type 1 by a clinically-applicable lentiviral vector2020 Molecular Therapy — Methods & Clinical Development erratum Medicine Lysosomal Storage Disorders Research Open access
Maria Dahl, Emma M. K. Smith, Sarah Warsi, Michael Rothe, Maria J. Ferraz, Johannes M. F. G. Aerts, +7 more
23citations -
Accelerated strain construction and characterization of C. glutamicum protein secretion by laboratory automation2022 Applied Microbiology and Biotechnology article Biochemistry, Genetics and Molecular Biology Bacterial Genetics and Biotechnology Open access cited by 1 patent
Carolin Müller, Patrick J. Bakkes, Vera Waffenschmidt, Laura M. Helleckes, Karl‐Erich Jaeger, Wolfgang Wiechert, +3 more
14citations -
Single-Cell-Multiomics Demonstrates Molecular Efficacy of a Clinical Lentiviral Vector for Gene Therapy of RPS19-Deficient Diamond-Blackfan Anemia2023 Blood conference-abstract Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research
Sofia Freiman, Jun Chen, Johan Flygare, Chayenne Kampman, Karin Pike‐Overzet, Alexander B. Mohseny, +6 more
1citations
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