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Analyzing the functional effects of DNA variants with gene editing2024 Cell Reports Methods article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 2 patents
Sarah Cooper, Sofia Obolenski, Andrew J. Waters, Andrew Roger Bassett, Matthew A. Coelho
13citations -
Precision genome editing using combinatorial viral vector delivery of CRISPR-Cas9 nucleases and donor DNA constructs2024 Nucleic Acids Research article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 1 patent
Zhen Li, Xiaoling Wang, Josephine M. Janssen, Jin Liu, Francesca Tasca, Rob C. Hoeben, +1 more
15citations -
Modulating CRISPR-Cas Genome Editing Using Guide-Complementary DNA Oligonucleotides2022 The CRISPR Journal article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Thomas Swartjes, Peng Shang, Dennis T.M. van den Berg, Tim Künne, Niels Geijsen, Stan J. J. Brouns, +3 more
0citations -
Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path2020 Nature Communications article Biochemistry, Genetics and Molecular Biology Protein Structure and Dynamics Open access
Thomas Dodd, Margherita M. Botto, Fabian Paul, Rafael Fernández-Leiro, Meindert Hugo Lamers, Ivaylo N. Ivanov
71citations -
Genetic dissection of mutagenic repair and T-DNA capture at CRISPR-induced DNA breaks in Arabidopsis thaliana2024 PNAS Nexus article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Lycka Kamoen, Lejon E. M. Kralemann, Robin van Schendel, Niels van Tol, Paul J. J. Hooykaas, Sylvia de Pater, +1 more
12citations -
Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks2022 Nature Communications article Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access cited by 1 patent
Bert van de Kooij, Alex Kruswick, Haico van Attikum, Michael B. Yaffe
69citations -
Competition between homologous chromosomal DNA and exogenous donor DNA to repair CRISPR/Cas9-induced double-strand breaks in Aspergillus niger2024 Fungal Biology and Biotechnology article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Selina Forrer, Mark Arentshorst, Prajeesh Kooloth-Valappil, Jaap Visser, Arthur F. J. Ram
0citations -
Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape2025 Nature Aging article Biochemistry, Genetics and Molecular Biology Epigenetics and DNA Methylation Open access
Sven Liesenfelder, Mohamed H. Elsafi Mabrouk, Jessica Iliescu, Monica Varona Baranda, Athanasia Mizi, Juan-Felipe Perez-Correa, +3 more
38citations -
Accurate characterization of CRISPR-Cas9 genome editing outcomes and mosaicism with near-perfect long reads2026 Genome Medicine article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Ida Höijer, Robin van Schendel, Anastasia Emmanouilidou, Rebecka Östlund, Ignas Bunikis, Marcel Tijsterman, +2 more
0citations -
Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways2023 Cell Reports article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 5 patents
Joost Schimmel, Núria Muñoz-Subirana, Hanneke Kool, Robin van Schendel, Sven van der Vlies, Juliette A. Kamp, +5 more
75citations -
CRISPR/Cas9 editing in conditionally immortalized HoxB8 cells for studying gene regulation in mouse dendritic cells2021 European Journal of Immunology article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Huaming Xu, Thomas A. Look, Sujeethkumar Prithiviraj, Daniel Lennartz, Manuel Delgado Cáceres, Katrin Götz, +5 more
13citations -
Large-scale genome editing based on high-capacity adenovectors and CRISPR-Cas9 nucleases rescues full-length dystrophin synthesis in DMD muscle cells2022 Nucleic Acids Research article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Francesca Tasca, Marcella Brescia, Qian Wang, Jin Liu, Josephine M. Janssen, Károly Szuhai, +1 more
21citations -
HideRNAs protect against CRISPR-Cas9 re-cutting after successful single base-pair gene editing2022 Scientific Reports article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Tim Harmsen, Colin E.J. Pritchard, Joey Riepsaame, Henri J. van de Vrugt, Ivo Johan Huijbers, Hein te Riele
4citations -
The translocated virulence protein VirD5 causes DNA damage and mutation during Agrobacterium -mediated transformation of yeast2022 Science Advances article Biochemistry, Genetics and Molecular Biology Fungal and yeast genetics research Open access
Xiaorong Zhang, Marjolein J. G. Hooykaas, Gerard Paul H. van Heusden, Paul J. J. Hooykaas
8citations -
Polθ‐mediated T‐ DNA integration is a conserved mechanism across plant species2026 The Plant Journal article Biochemistry, Genetics and Molecular Biology Plant tissue culture and regeneration Open access
Lejon E. M. Kralemann, Ayako Nishizawa‐Yokoi, Frank Meulewaeter, Maarten H. Stuiver, Anne‐Marie Kuijpers, Seiichi Toki, +2 more
0citations -
Generation of a STRAIGHT-IN Dual AAVS1 hiPSC line with orthogonal landing pads for versatile DNA payload integration2026 Stem Cell Research article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Babet van der Vaart, Albert Blanch-Asensio, Niels Geijsen, Christine L. Mummery, Richard P. Davis
0citations -
Generation of AAVS1 and CLYBL STRAIGHT-IN v2 acceptor human iPSC lines for integrating DNA payloads2022 Stem Cell Research article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 1 patent
Albert Blanch-Asensio, Babet van der Vaart, Mariana Vinagre, Eline Groen, Christiaan H. Arendzen, Christian M.A.H. Freund, +3 more
20citations -
Intradermal Naked DNA Vaccination by DNA Tattooing for Mounting Tumor-Specific Immunity in Stage IV Melanoma Patients: A Phase I Clinical Trial2024 Oncology Research and Treatment article Immunology and Microbiology Immunotherapy and Immune Responses Open access
Marnix H. Geukes Foppen, Maartje W. Rohaan, Jessica S.W. Borgers, Daisy Philips, Florry A. Vyth‐Dreese, Jos H. Beijnen, +3 more
6citations -
Adenine base editing of the DUX4 polyadenylation signal for targeted genetic therapy in facioscapulohumeral muscular dystrophy2021 Molecular Therapy — Nucleic Acids article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 2 patents
Darina Šikrová, Vlad A. Cadar, Yavuz Ariyürek, Jeroen F. J. Laros, Judit Balog, Silvère M. van der Maarel
23citations