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Utility of Extrapolating Human S1500+ Genes to the Whole Transcriptome: Tunicamycin Case Study2020 Bioinformatics and Biology Insights article Biochemistry, Genetics and Molecular Biology Gene expression and cancer classification Open access
Deepak Mav, Dhiral P. Phadke, Michele R. Balik-Meisner, Bruce Alex Merrick, Scott S. Auerbach, Marije Niemeijer, +7 more
10citations -
Mining a human transcriptome database for chemical modulators of NRF22020 PLoS ONE article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
John P. Rooney, Brian N. Chorley, Steven W. Hiemstra, Steven Wink, Xuting Wang, Douglas A. Bell, +2 more
54citations -
Deconvolution of cellular subsets in human tissue based on targeted DNA methylation analysis at individual CpG sites2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Epigenetics and DNA Methylation Open access
Marco F. Schmidt, Tiago Maié, Edgar Dahl, Ivan G. Costa, Wolfgang Wagner
2citations -
Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses2022 Toxicology in Vitro article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Bas ter Braak, Janna E. Klip, Steven Wink, Steven W. Hiemstra, Sarah Lucy Cooper, A. Middleton, +2 more
8citations -
Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids
Samantha V. Llewellyn, Ali Kermanizadeh, Victor Chibueze Ude, Nicklas Raun Jacobsen, Gillian E. Conway, Ume-Kulsoom Shah, +8 more
11citations -
Absence of JNK activity in hepatocytes exacerbates liver injury and fibrosis during chronic cholestasis in mice2020 Zeitschrift für Gastroenterologie conference-paper Medicine Liver physiology and pathology Open access
Mohamed Ramadan Mohamed, FJ Cubero, Johannes Haybäck, M.V. Boekschoten, RJ Davis, Christian Trautwein
0citations -
JNK mediates differential protection in hepatocytes and non-parenchymal cells during cholestasis2021 Zeitschrift für Gastroenterologie conference-paper Medicine Liver physiology and pathology Open access
Mohamed Ramadan Mohamed, Yulia Alexandrowna Nevzorova, Johannes Haybaeck, M.V. Boekschoten, Peter Boor, Pavel Strnad, +4 more
0citations -
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes2021 Cell Biology and Toxicology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Lukas S. Wijaya, Carina Rau, Theresa Braun, Serif Marangoz, Vincent Spegg, Matthijs Vlasveld, +8 more
15citations -
Scalable production of tissue-like vascularised liver organoids from human PSCs2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access cited by 1 patent
Sean Philip Harrison, Richard Siller, Yoshiaki Tanaka, Yangfei Xiang, Benjamin Patterson, Henning Kempf, +22 more
12citations -
Fast and efficient generation of knock-in human organoids using homology-independent CRISPR/Cas9 precision genome editing2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 15 patents
Benedetta Artegiani, Delilah F. G. Hendriks, Joep Beumer, Rutger N.U. Kok, Xuan Zheng, Indi P. Joore, +4 more
29citations -
Scalable production of tissue-like vascularized liver organoids from human PSCs2023 Experimental & Molecular Medicine article Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access cited by 5 patents
Sean Philip Harrison, Richard Siller, Yoshiaki Tanaka, María Eugenia Chollet, María Eugenia de la Morena‐Barrio, Yangfei Xiang, +29 more
120citations -
COMBINATION THERAPY WITH A SENSE OLIGONUCLEOTIDE TO INDUCIBLE NITRIC OXIDE SYNTHASE MRNA AND HUMAN SOLUBLE THROMBOMODULIN IMPROVES SURVIVAL OF SEPSIS MODEL RATS AFTER PARTIAL HEPATECTOMY
Richi Nakatake, Masaya Kotsuka, Morihiko Ishizaki, Hiroaki Kitade, Katsuhiko Yoshizawa, Rene Hany Tolba, +2 more
3citations -
1181 Therapeutic vaccines consisting of cancer germline antigen-based synthetic long peptides are immunogenic in human hepatocellular carcinoma patients2022 Regular and Young Investigator Award Abstracts conference-abstract Immunology and Microbiology Immunotherapy and Immune Responses Open access
Yannick Sebastiaan Rakké, Marij Schoenmaekers-Welters, Lisanne Noordam, Sanne Boekestijn, Luc Magré, Robbie J. Luijten, +12 more
0citations -
Recapitulating Cholangiopathy-Associated Necroptotic Cell Death In Vitro Using Human Cholangiocyte Organoids2021 Cellular and Molecular Gastroenterology and Hepatology article Medicine Liver Diseases and Immunity Open access
Shaojun Shi, Monique M. A. Verstegen, Henk P. Roest, Arif Ibrahim Ardisasmita, Wanlu Cao, Floris J.M. Roos, +5 more
40citations -
Novel short-termed mouse model of intrahepatic cholangiocarcinoma by orthotopic transplantation of Hep-55.1C in mice with human homology2022 Zeitschrift für Gastroenterologie article Medicine Cholangiocarcinoma and Gallbladder Cancer Studies
TheresaHildegard Wirtz, Elisa Fabiana Brandt, Petra Fischer, Christian H. Holland, A Röth, Maike Baues, +7 more
0citations -
Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis2023 Nature Biotechnology article Medicine Liver Disease Diagnosis and Treatment Open access cited by 1 patent
Delilah F. G. Hendriks, Jos F.H.M. Brouwers, Karien M. Hamer, Maarten H. Geurts, Léa Luciana, Simone Massalini, +6 more
248citations -
Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids2020 Cell Systems article Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access cited by 1 patent
Jeremy J. Velazquez, Ryan LeGraw, Farzaneh Moghadam, Yuqi Tan, Jacquelyn A. Kilbourne, Joseph C. Maggiore, +8 more
110citations