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Precise and broad scope genome editing based on high-specificity Cas9 nickases2020 Nucleic Acids Research article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Qian Wang, Jin Liu, Josephine M. Janssen, Marie Le Bouteiller, Richard L. Frock, Manuel A.F.V. Gonçalves
36citations -
Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components2020 Gene Therapy article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 1 patent
Ignazio Maggio, Hidde A. Zittersteijn, Qian Wang, Jin Liu, Josephine M. Janssen, Ivan Toral Ojeda, +4 more
66citations -
Consensus guidelines for assessing eligibility of pathogenic DNA variants for antisense oligonucleotide treatments2025 The American Journal of Human Genetics article Biochemistry, Genetics and Molecular Biology Genomics and Rare Diseases Open access
David Cheerie, Margaret M. Meserve, Danique Beijer, Charu Kaiwar, Logan Newton, Ana Lisa Taylor Tavares, +33 more
31citations -
Targeted mutagenesis in Nicotiana tabacum ADF gene using shockwave‐mediated ribonucleoprotein delivery increases osmotic stress tolerance2021 Physiologia Plantarum article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 1 patent
Sruthy Maria Augustine, Anoop Vadakan Cherian, Kerstin Seiling, Nicole P. G. Raven, Ulrich Commandeur, Stefan Schillberg
12citations -
A perspective on causality assessment in epigenetic research on neurodegenerative disorders2022 Neural Regeneration Research article Biochemistry, Genetics and Molecular Biology Epigenetics and DNA Methylation Open access
Philippos Koulousakis, Assia Tiane, Niels Hellings, Jos Prickaerts, Daniël van den Hove, Tim Vanmierlo
8citations -
Retained chromosomal integrity following CRISPR-Cas9-based mutational correction in human embryos2023 Molecular Therapy article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Bieke Bekaert, Annekatrien Boel, Lisa De Witte, Winter Vandenberghe, Mina Popovic, Panagiotis Stamatiadis, +9 more
6citations -
CRISPR/Cas9 Mutagenesis by Translocation of Cas9 Protein Into Plant Cells via the Agrobacterium Type IV Secretion System2020 Frontiers in Genome Editing article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Daan J. Schmitz, Zahir Ali, Chenglong Wang, Fatimah Aljedaani, Paul J. J. Hooykaas, Magdy M. Mahfouz, +1 more
23citations -
Exploiting Synthetic Lethality between Germline BRCA1 Haploinsufficiency and PARP Inhibition in JAK2V617F-Positive Myeloproliferative Neoplasms2023 International Journal of Molecular Sciences article Medicine PARP inhibition in cancer therapy Open access
Max Bermes, María Jimena Rodriguez, Marcelo A. S. Toledo, Sabrina Ernst, Gerhard Müller‐Newen, Tim H. Brümmendorf, +3 more
7citations -
Generation of four gene-edited human induced pluripotent stem cell lines with mutations in the ATM gene to model Ataxia-Telangiectasia2023 Stem Cell Research article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Wasifa Nurieva, Sanabel Chehab, Parth Singh, Marina Reichlmeir, Károly Szuhai, Georg W. J. Auburger, +2 more
4citations -
Various repair events following CRISPR/Cas9-based mutational correction of an infertility-related mutation in mouse embryos2024 Journal of Assisted Reproduction and Genetics article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Bieke Bekaert, Annekatrien Boel, Andreï Rybouchkin, Gwenny Cosemans, Sofie Declercq, Susana M. Chuva de Sousa Lopes, +5 more
4citations -
P-802 Distinct genetic impact of CRISPR/Cas9 gene correction in human embryos compared to induced pluripotent stem cells2022 Human Reproduction article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Bieke Bekaert, Annekatrien Boel, Lisa De Witte, Gwenny Cosemans, Lise Tordeurs, A M De Loore, +6 more
0citations -
Precise homology-directed installation of large genomic edits in human cells with cleaving and nicking high-specificity Cas9 variants2023 Nucleic Acids Research article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Qian Wang, Jin Liu, Josephine M. Janssen, Manuel A.F.V. Gonçalves
19citations -
CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations2022 Nature Communications article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 1 patent
Ida Höijer, Anastasia Emmanouilidou, Rebecka Östlund, Robin van Schendel, Selma Bozorgpana, Marcel Tijsterman, +4 more
196citations -
High-capacity adenovector delivery of forced CRISPR-Cas9 heterodimers fosters precise chromosomal deletions in human cells2023 Molecular Therapy — Nucleic Acids article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Francesca Tasca, Marcella Brescia, Jin Liu, Josephine M. Janssen, Kamel Mamchaoui, Manuel A.F.V. Gonçalves
7citations -
Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia2022 Science Translational Medicine article Medicine CAR-T cell therapy research Open access cited by 2 patents
Giorgio Ottaviano, Christos Georgiadis, Soragia Athina Gkazi, Farhatullah Syed, Hong Zhan, Annie Etuk, +52 more
204citations -
Potential of the endogenous and artificially inserted CRISPR-Cas system for controlling virulence and antimicrobial resistance of food pathogens2023 Food Chemistry Advances article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Ramila Cristiane Rodrigues, Thaysa Leite Tagliaferri, Tiago Antônio de Oliveira Mendes
6citations