Papers matching “site-directed mutagenesis” 57
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Identification of residues involved in homotrimeric assembly of the human P2X4 receptor by simulations and site-directed mutagenesis2023 Biophysical Journal article Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling Open access
Aparna Sai Malisetty, Lukas Schaffrath, F Markwárdt, Saskia Cönen, Jan‐Philipp Machtens, Susan Köppen, +1 more
0citations -
Human leukocyte antigen epitope definition using site-directed mutagenesis2023 Korean Journal of Transplantation article Biochemistry, Genetics and Molecular Biology vaccines and immunoinformatics approaches Open access
David Y. Suh, Ujjwala Singh, David P. Lowe, Shi‐Yuan Meng, Fred Quiroz, Cynthia S. M. Kramer, +2 more
0citations -
Site‐directed mutagenesis of HLA molecules reveals the functional epitope of a human HLA‐A1 / A36 ‐specific monoclonal antibody2022 HLA article Biochemistry, Genetics and Molecular Biology vaccines and immunoinformatics approaches Open access cited by 2 patents
Shi‐Yuan Meng, Suzanne Bezstarosti, Ujjwala Singh, Michelle Yap, Laura Scott, Naiiry Petrosyan, +10 more
7citations -
Exploring the intracellular allosteric binding site of CC Chemokine receptor 5 with a novel radioligand and mutagenesis - Pharmacophore Analysis0citations
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Exploring the intracellular allosteric binding site of CC Chemokine receptor 5 with a novel radioligand and mutagenesis - Pharmacophore Analysis0citations
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Critical assessment of structure-based approaches to improve protein resistance in aqueous ionic liquids by enzyme-wide saturation mutagenesis2021 Computational and Structural Biotechnology Journal article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access
Till El Harrar, Mehdi D. Davari, Karl‐Erich Jaeger, Ulrich Schwaneberg, Holger Gohlke
14citations -
Tuning the H 2 Production Activity of ToHydA by Molecular Simulation-Informed Protein Engineering2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Energy Metalloenzymes and iron-sulfur proteins Open access
Chandan Kumar Das, Subhasri Ghosh, Shuvankar Naskar, Thomas Happe, Lars V. Schäfer
0citations -
Conserved residues Glu37 and Trp229 play an essential role in protein folding of β‐lactamase2021 FEBS Journal article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access
Aleksandra Chikunova, Max P. Manley, Misbha Ud Din Ahmad, Tuğçe Bilman, Anastassis Perrakis, Marcellus Ubbink
9citations -
Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication2021 Proceedings of the National Academy of Sciences article Medicine SARS-CoV-2 and COVID-19 Research Open access cited by 1 patent
Natacha S. Ogando, Priscila El Kazzi, Jessika C. Zevenhoven-Dobbe, Brenda W. Bontes, Alice Decombe, Clara C. Posthuma, +5 more
53citations -
bacLIFE: a user-friendly computational workflow for genome analysis and prediction of lifestyle-associated genes in bacteria2024 Nature Communications article Biochemistry, Genetics and Molecular Biology Genomics and Phylogenetic Studies Open access
Guillermo Guerrero-Egido, Adrián Pintado, Kevin M. Bretscher, Luisa M. Arias-Giraldo, Joseph Nathaniel Paulson, Herman P. Spaink, +6 more
29citations -
Protein Dynamics Affect O 2 -Stability of Group B [FeFe]-Hydrogenase from Thermosediminibacter oceani2025 Journal of the American Chemical Society article Energy Metalloenzymes and iron-sulfur proteins Open access
Subhasri Ghosh, Chandan Kumar Das, Sven Timo Stripp, Vera Engelbrecht, Martin Winkler, Silke Leimkühler, +4 more
20citations -
Reaction mechanism of the farnesyl pyrophosphate C-methyltransferase towards the biosynthesis of pre-sodorifen pyrophosphate by Serratia plymuthica 4Rx132021 Scientific Reports article Biochemistry, Genetics and Molecular Biology Plant biochemistry and biosynthesis Open access
Marie Chantal Lemfack, Wolfgang Brandt, Katja Krüger, Alexandra Gurowietz, Jacky Djifack, Jan-Philip Jung, +5 more
20citations -
Design and pharmacological profile of a novel covalent partial agonist for the adenosine A1 receptor2020 Biochemical Pharmacology article Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling Open access
Xue Fei Yang, Majlen A. Dilweg, Dion Osemwengie, Lindsey Burggraaff, Daan van der Es, Laura H. Heitman, +1 more
16citations -
Comprehensive comparative assessment of the Arabidopsis thaliana MLO2–CALMODULIN2 interaction by various in vitro and in vivo protein–protein interaction assays2023 Biochemical Journal article Agricultural and Biological Sciences Powdery Mildew Fungal Diseases Open access
Kira von Bongartz, Björn Sabelleck, Anežka Baquero Forero, Hannah Kuhn, Franz Leissing, Ralph Panstruga
7citations -
Protein dynamics affect O 2 -stability of Group B [FeFe]-hydrogenase from Thermosediminibacter oceani2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Energy Metalloenzymes and iron-sulfur proteins Open access
Subhasri Ghosh, Sven Timo Stripp, Vera Engelbrecht, Martin Winkler, Silke Leimkühler, Jifu Duan, +1 more
1citations -
Comprehensive comparative assessment of the Arabidopsis thaliana MLO2-calmodulin interaction by various in vitro and in vivo protein-protein interaction assays2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Agricultural and Biological Sciences Powdery Mildew Fungal Diseases Open access
Kira von Bongartz, Björn Sabelleck, Anežka Baquero Forero, Hannah Kuhn, Franz Leissing, Ralph Panstruga
1citations -
Design, Synthesis and Pharmacological Profile of LUF7746, a Novel Covalent Partial Agonist for the Adenosine A1 Receptor2020 ChemRxiv preprint Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling Open access
Xue Fei Yang, Majlen A. Dilweg, Dion Osemwengie, Lindsey Burggraaff, Daan van der Es, Laura H. Heitman, +1 more
0citations -
Design, Synthesis and Pharmacological Profile of LUF7746, a Novel Covalent Partial Agonist for the Adenosine A1 Receptor2020 ChemRxiv preprint Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling Open access
Xue Fei Yang, Majlen A. Dilweg, Dion Osemwengie, Lindsey Burggraaff, Daan van der Es, Laura H. Heitman, +1 more
0citations -
Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine SARS-CoV-2 and COVID-19 Research Open access
Natacha S. Ogando, Priscila El Kazzi, Jessika C. Zevenhoven-Dobbe, Brenda W. Bontes, Alice Decombe, Clara C. Posthuma, +5 more
0citations -
Modulating the Coupling Efficiency of P450 BM3 by Controlling Water Diffusion through Access Tunnel Engineering2021 ChemSusChem article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access cited by 1 patent
Shuaiqi Meng, Yu Ji, Luo Liu, Mehdi D. Davari, Ulrich Schwaneberg
24citations -
Can constraint network analysis guide the identification phase of KnowVolution? A case study on improved thermostability of an endo-β-glucanase2020 Computational and Structural Biotechnology Journal article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access
Francisca Contreras, Christina Nutschel, Laura Beust, Mehdi D. Davari, Holger Gohlke, Ulrich Schwaneberg
12citations -
Reversal of Regioselectivity in Zinc‐Dependent Medium‐Chain Alcohol Dehydrogenase from Rhodococcus erythropolis toward Octanone Derivatives2020 ChemBioChem article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access cited by 1 patent
Gaurao V. Dhoke, Yunus Ensari, Dinc Yasat Hacibaloglu, Anna Gärtner, Anna Joëlle Ruff, Marco Bocola, +1 more
8citations -
A glycine at position 105 leads to clavulanic acid and avibactam resistance in class A β-lactamases2025 Journal of Biological Chemistry article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access
Marko Radojković, Aleksandra Chikunova, Saar F. Koene, Monika Timmer, Sivanandam V. Natarajan, Aimee L. Boyle, +1 more
2citations -
Tuning the Transglycosylation Reaction of a GH11 Xylanase by a Delicate Enhancement of its Thumb Flexibility2021 ChemBioChem article Biochemistry, Genetics and Molecular Biology Protein Structure and Dynamics Open access
Kim Marneth, Hans van den Elst, Anneloes Cramer‐Blok, Jeroen D. C. Codée, Herman S. Overkleeft, Johannes M. F. G. Aerts, +2 more
18citations