The Minimum Information about a Tailoring Enzyme/Maturase data standard for capturing natural product biosynthesis
Abstract
Natural products, also known as specialized or secondary metabolites, show extraordinary chemical diversity and potent biological activities. Their biosynthesis usually first encompasses scaffold generation, followed by additional tailoring and maturation steps, leading to the mature compound. The latter steps are often performed by accessory enzymes known as tailoring enzymes or maturases. While knowledge about reaction and substrate specificities of these enzymes is essential for natural product biosynthesis, it is often scattered in the literature, hampering understanding and computational processing. Here, we conceptualize the Minimum Information about a Tailoring Enzyme/Maturase (MITE) data standard. We envision this data standard to serve in collecting experimentally verified data on reaction, substrate specificity, and other metadata of tailoring enzymes. Closely associated with the previously established Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard, MITE will aim to capture tailoring enzyme reaction information that is currently not systemized. We anticipate that MITE will accelerate natural product structure predictions from sequence, evolutionary analyses of biosynthetic pathways and synthetic biology engineering of specialized metabolic pathways.
Authors 21
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Wageningen University & Research
Affiliation as printed
Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, the Netherlands
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Wageningen University & Research
Affiliation as printed
Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, the Netherlands
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Goethe University Frankfurt · LOEWE Centre for Translational Biodiversity Genomics · Wageningen University & Research
Affiliation as printed
Institute of Molecular Bio Science, Goethe-University Frankfurt, Frankfurt am Main, Germany
LOEWE Center for Translational Biodiversity Genomics (TBG), Frankfurt am Main, Germany
Wageningen University & Research
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Affiliation as printed
Department of Biotechnology and Nanomedicine, SINTEF Industry, P.O. Box 4760 Torgard, N-7465, Trondheim, Norway
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Affiliation as printed
Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Germany
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Wageningen University & Research
Affiliation as printed
Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, the Netherlands
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Wageningen University & Research
Affiliation as printed
Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, the Netherlands
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Wageningen University & Research
Affiliation as printed
Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, the Netherlands
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Affiliation as printed
Department of Biotechnology and Nanomedicine, SINTEF Industry, P.O. Box 4760 Torgard, N-7465, Trondheim, Norway
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ETH Zurich · Institute for Molecular Systems Biology
Affiliation as printed
Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
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SIB Swiss Institute of Bioinformatics
Affiliation as printed
SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, CH-1211, Geneva, Switzerland
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Novo Nordisk Foundation · Technical University of Denmark
Affiliation as printed
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark
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Affiliation as printed
Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands
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Wageningen University & Research
Affiliation as printed
Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, the Netherlands
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SIB Swiss Institute of Bioinformatics
Affiliation as printed
SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, CH-1211, Geneva, Switzerland
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SIB Swiss Institute of Bioinformatics
Affiliation as printed
SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, CH-1211, Geneva, Switzerland
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University of Johannesburg · Wageningen University & Research
Affiliation as printed
Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, the Netherlands
Department of Biochemistry, University of Johannesburg, Auckland Park, Johannesburg 2006, South Africa
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Novo Nordisk Foundation · Technical University of Denmark
Affiliation as printed
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark
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Affiliation as printed
Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Germany
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Novo Nordisk Foundation · Technical University of Denmark
Affiliation as printed
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark
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Wageningen University & Research
Affiliation as printed
Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, the Netherlands
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