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October 28, 2024 article Open access Aachen paper

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Nucleic Acids Research, vol. 53, pp. D678–D690

DOI: 10.1093/nar/gkae1115 Full text (OA) OpenAlex

Abstract

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/.

Authors 96

  1. Mitja M. Zdouc

    Wageningen University & Research

    Affiliation as printed

    Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,

    WUR - Wageningen University and Research [Wageningen] (Droevendaalsesteeg 4, 6708 PB Wageningen - Netherlands)

  2. Kai Blin

    Novo Nordisk Foundation · Technical University of Denmark

    Affiliation as printed

    The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Building 220, Søltofts Plads, 2800 Kongens Lyngby,

  3. Nico L L Louwen

    Wageningen University & Research

    Affiliation as printed

    Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,

    WUR - Wageningen University and Research [Wageningen] (Droevendaalsesteeg 4, 6708 PB Wageningen - Netherlands)

  4. Jorge Carlos Navarro-Muñoz

    Wageningen University & Research

    Affiliation as printed

    Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,

    WUR - Wageningen University and Research [Wageningen] (Droevendaalsesteeg 4, 6708 PB Wageningen - Netherlands)

  5. Catarina Loureiro

    Wageningen University & Research

    Affiliation as printed

    Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,

    WUR - Wageningen University and Research [Wageningen] (Droevendaalsesteeg 4, 6708 PB Wageningen - Netherlands)

  6. Chantal Denise Bader

    Helmholtz Centre for Infection Research · Helmholtz Institute for Pharmaceutical Research Saarland

    Affiliation as printed

    Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,

  7. Constance B. Bailey

    The University of Sydney

    Affiliation as printed

    School of Chemistry, Chemistry Building, University of Sydney , Eastern Ave, Camperdown NSW 2050 , Sydney , New South Wales ,

  8. Lena Barra

    University of Konstanz

    Affiliation as printed

    Department of Chemistry, University of Konstanz, Universitätsstraße 10 , 78464  Konstanz ,

  9. Thomas Booth

    Novo Nordisk Foundation · Technical University of Denmark

    Affiliation as printed

    The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Building 220, Søltofts Plads, 2800 Kongens Lyngby,

  10. Kenan A. J. Bozhüyük

    Helmholtz Centre for Infection Research · Helmholtz Institute for Pharmaceutical Research Saarland

    Affiliation as printed

    Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,

    Myria Biosciences AG, Tech Park Basel , Hochbergstrasse 60C, 4057  Basel ,

  11. José D D Cediel-Becerra

    University of Florida

    Affiliation as printed

    Department of Microbiology and Cell Science, University of Florida , 1355 Museum Drive, Gainesville , Florida , 32611 ,

  12. Zachary Charlop–Powers

    Ginkgo Bioworks, Inc. (United States)

    Affiliation as printed

    Ginkgo Bioworks , 27 Drydock Avenue, 8th Floor, Boston , MA  02210 ,

  13. Marc G. Chevrette

    University of Florida

    Affiliation as printed

    Department of Microbiology and Cell Science, University of Florida , 1355 Museum Drive, Gainesville , Florida , 32611 ,

    University of Florida Genetics Institute, University of Florida , 2033 Mowry Rd, Gainesville , FL 32611 ,

    UFGI - University of Florida Genetics Institute (University of Florida, Gainesville, FL 32610 - United States)

  14. Yit‐Heng Chooi

    The University of Western Australia

    Affiliation as printed

    School of Molecular Sciences, University of Western Australia , 35 Stirling Highway, Perth  6009 ,

    School of Molecular Sciences, The University of Western Australia, Perth 6009, Australia (Australia)

  15. Paul Michael D'Agostino

    Helmholtz Centre for Infection Research · Helmholtz Institute for Pharmaceutical Research Saarland · Technische Universität Dresden

    Affiliation as printed

    Chair of Technical Biochemistry, Technical University of Dresden , Bergstraße 66, 01069  Dresden ,

    Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,

  16. Tristan de Rond

    University of Auckland

    Affiliation as printed

    School of Chemical Sciences, University of Auckland , 23 Symonds St, Auckland  1010 ,

    School of Chemical Sciences [Auckland] (The University of Auckland, 23 Symonds St., Auckland, New Zealand - New Zealand)

  17. Elena Del Pup

    Wageningen University & Research

    Affiliation as printed

    Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,

    WUR - Wageningen University and Research [Wageningen] (Droevendaalsesteeg 4, 6708 PB Wageningen - Netherlands)

  18. Katherine Duncan

    Newcastle University

    Affiliation as printed

    Newcastle University, Biosciences Institute , Catherine Cookson Building, Newcastle upon Tyne , NE2 4HH ,

    Biosciences Institute, Faculty of Medical Sciences [Newcastle] (Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom - United Kingdom)

  19. Wenjia Gu

    Sutro Biopharma (United States)

    Affiliation as printed

    Sutro Biopharma , 111 Oyster Point Blvd, South San Francisco , CA , 94080 ,

  20. Novriyandi Hanif

    IPB University

    Affiliation as printed

    Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University , Gedung Kimia Wing 1 Lantai 3, Jalan Tanjung Kampus IPB Dramaga, Bogor, Jawa Barat 16680 ,

  21. Eric J. N. Helfrich

    Goethe University Frankfurt · Senckenberg - Leibniz Institution for Biodiversity and Earth System Research · LOEWE Centre for Translational Biodiversity Genomics

    Affiliation as printed

    Institute for Molecular Bio Science, Goethe University Frankfurt , Max-von-Laue Strasse 9, 60438  Frankfurt am Main,

    LOEWE Center for Translational Biodiversity Genomics (TBG) , Senckenberganlage 25, 60325  Frankfurt am Main,

    Senckenberg Society for Nature Research , Senckenberganlage 25, 60325  Frankfurt am Main,

  22. Matthew Jenner

    University of Warwick

    Affiliation as printed

    Department of Chemistry, University of Warwick , Gibbet Hill Rd, Coventry , CV4 7AL ,

    Warwick Integrative Synthetic Biology Centre (WISB), University of Warwick , Gibbet Hill Rd, Coventry , CV4 7AL ,

    Department of Chemistry [University of Warwick] (University of Warwick, Coventry CV4 7AL, UK - United Kingdom)

  23. Yohei Katsuyama

    The University of Tokyo

    Affiliation as printed

    Collaborative Research Institute for Innovative Microbiology, The University of Tokyo , 1-1-1, Yayoi, Bunkyo-ku, Tokyo , 113-8657 ,

    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo , 1-1-1, Yayoi, Bunkyo-ku, Tokyo , 113-8657 ,

  24. Aleksandra E. Korenskaia

    University of Tübingen

    Affiliation as printed

    Translational Genome Mining for Natural Products, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen , Sand 14, 72076 Tübingen,

  25. Daniel Krug

    Helmholtz Centre for Infection Research · Helmholtz Institute for Pharmaceutical Research Saarland · Saarland University

    Affiliation as printed

    Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI) , Inhoffenstr. 7, 38124  Braunschweig ,

    Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,

    Saarland University, Campus E8.1 , 66123 Saarbrücken,

  26. Vincent K. Libis

    Inserm · Université Paris Cité

    Affiliation as printed

    Translational Genome Mining for Natural Products, Generare Bioscience , 75011  Paris , Île-de-France,

    Université Paris Cité - Inserm Unit 1284 , 75015  Paris ,

  27. George Lund

    Rothamsted Research

    Affiliation as printed

    Sustainable Soils and Crops, Rothamsted Research , West Common, Harpenden , Hertfordshire , AL5 2JQ ,

  28. Shrikant Subhash Mantri

    Regional Centre for Biotechnology · BRIC-National Agri-Food and Biomanufacturing Institute

    Affiliation as printed

    Computational Biology Lab, National Agri-Food and Biomanufacturing Institute (NABI) , Sector 81, S.A.S. Nagar , Mohali , Punjab  140306 ,

    Regional Centre for Biotechnology, NCR Biotech Science Cluster , 3rd Milestone, Faridabad -Gurugram Expressway, Faridabad - 121001 Haryana (NCR Delhi ),

  29. Kalindi D. Morgan

    University of Northern British Columbia

    Affiliation as printed

    Department of Chemistry and Biochemistry, University of Northern British Columbia, 3333 University Way , Prince George, BC , V2N 4Z9 ,

  30. Charlotte Owen

    John Innes Centre · Norwich Research Park

    Affiliation as printed

    Biochemistry and Metabolism, John Innes Centre , Norwich Research Park, Colney Lane, Norwich , NR4 7UH ,

    Department of Biochemistry and Metabolism, Department of Biochemistry and Metabolism, John Innes Centre, Norwich NR4 7UH, United Kingdom (United Kingdom)

  31. Chin‐Soon Phan

    Latvijas Organiskās Sintēzes Institūts

    Affiliation as printed

    Latvian Institute of Organic Synthesis , Aizkraukles street 21, LV-1006  Riga ,

    Latvian Institute of Organic Synthesis [Riga, Lituania] (Aizkraukles 21, 1006, Riga, Latvia - Lithuania)

  32. Benjamin J. Philmus

    Oregon State University

    Affiliation as printed

    Department of Pharmaceutical Sciences, Oregon State University , 1601 SW Jefferson Way, Corvallis , OR 97331-3507 ,

  33. Zachary L. Reitz

    University of California, Santa Barbara

    Affiliation as printed

    Department of Ecology, Evolution and Marine Biology, University of California , 1169 Biological Sciences II, Santa Barbara , CA  93106 ,

  34. Serina L. Robinson

    Swiss Federal Institute of Aquatic Science and Technology

    Affiliation as printed

    Department of Environmental Microbiology, Swiss Federal Institute of Aquatic Science and Technology , Ueberlandstrasse 133, 8600 Duebendorf,

  35. Kumar Saurabh Singh

    Utrecht University · University of Exeter · Wageningen University & Research

    Affiliation as printed

    Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,

    Faculty of Environment, Science and Economy, University of Exeter , TR10 9FE , Penryn , Cornwall ,

    Plant-Microbe Interactions, Institute of Environmental Biology, Utrecht University , 3584 CH Utrecht ,

    WUR - Wageningen University and Research [Wageningen] (Droevendaalsesteeg 4, 6708 PB Wageningen - Netherlands)

  36. Robin Teufel

    University of Basel

    Affiliation as printed

    Department of Pharmaceutical Sciences, University of Basel , Klingelbergstrasse 50, 4056  Basel ,

  37. Yaojun Tong

    Shanghai Jiao Tong University · State Key Laboratory of Microbial Metabolism

    Affiliation as printed

    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Minhang District, Shanghai  200240 ,

  38. Fidele Tugizimana

    University of Johannesburg

    Affiliation as printed

    Department of Biochemistry, University of Johannesburg, C2 Lab Building 224, Kingsway Campus, Cnr University & Kingsway Road , Auckland Park, Johannesburg  2006 ,

    International Research and Development (R&D) Division , Omnia Nutriology, Omnia Holdings Ltd, Building H, Monte Circle, 178 Montecasino Blvd, Fourways , Sandton , 2055 ,

  39. Dana Ulanová

    University of Kochi · Kōchi University

    Affiliation as printed

    Department of Marine Resource Science, Faculty of Agriculture and Marine Science, Kochi University , 200 Otsu , Monobe, Nankoku -shi, Kochi , 783-8502 ,

    Marine Core Research Institute, Kochi University , 200 Otsu , Monobe, Nankoku -shi, Kochi , 783-8502 ,

  40. Jaclyn M. Winter

    University of Utah

    Affiliation as printed

    Department of Pharmacology and Toxicology, University of Utah , 30 S 2000 E, Salt Lake City, Utah , 84112 ,

  41. César Aguilar

    Purdue University West Lafayette · Tecnológico de Monterrey

    Affiliation as printed

    Department of Chemistry, Purdue University , 610 Purdue Mall, West Lafayette , IN, 47907 ,

    Industrial Genomics Laboratory , Centro de Biotecnología FEMSA, Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501 sur , Nuevo Leon, 64700 ,

    Purdue University [West Lafayette] (Hovde Hall, 610 Purdue Mall, West Lafayette, IN 47907 - United States)

  42. Daniel Yuri Akiyama

    Universidade Estadual de Campinas (UNICAMP)

    Affiliation as printed

    Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP) , Rua Monteiro Lobato 270, Campinas, São Paulo , 13.083-862,

  43. Suhad A. A. Al-Salihi

    University of Technology - Iraq

    Affiliation as printed

    Department of Applied Sciences, University of Technology , Al-Sina’a St., 10066 , Baghdad ,

  44. Mohammad M. Alanjary

    Wageningen University & Research

    Affiliation as printed

    Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,

    WUR - Wageningen University and Research [Wageningen] (Droevendaalsesteeg 4, 6708 PB Wageningen - Netherlands)

  45. Fabrizio Alberti

    University of Warwick

    Affiliation as printed

    School of Life Sciences, University of Warwick , Gibbet Hill Road, Coventry , CV4 7AL ,

  46. Gajender Aleti

    Tennessee State University

    Affiliation as printed

    Department of Food and Animal Sciences, College of Agriculture, Tennessee State University , Nashville , TN 37209 ,

  47. Shumukh A. Alharthi

    Swansea University

    Affiliation as printed

    Department of Biosciences, Swansea University , Singleton Park, Swansea , SA2 8PP ,

    SWANSEA UNIVERSITY DEPARTMENT OF BIOSCIENCES SWANSEA GBR (United Kingdom)

  48. Amr Abker Arishi

    The University of Western Australia · King Saud University

    Affiliation as printed

    Department of Botany and Microbiology, College of Science, King Saud University , P.O. Box 2455 , Riyadh , 11451 ,

    School of Molecular Sciences, University of Western Australia , 35 Stirling Highway, Perth  6009 ,

    Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia (Saudi Arabia)

    School of Molecular Sciences, The University of Western Australia, Perth 6009, Australia (Australia)

  49. Hannah E. Augustijn Aachen Institute of Biology, Leiden University

    Leiden University · Wageningen University & Research

    Affiliation as printed

    Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,

    Institute of Biology, Leiden University , Sylviusweg 72, 2333BE  Leiden ,

    IBL - Institute Biology Leiden (Faculty of Science PO Box 9516 2300 RA Leiden - Netherlands)

    WUR - Wageningen University and Research [Wageningen] (Droevendaalsesteeg 4, 6708 PB Wageningen - Netherlands)

  50. Nicole E. Avalon

    Scripps Institution of Oceanography · University of California San Diego

    Affiliation as printed

    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego , 9500 Gilman Drive, La Jolla , CA  92093-0212 ,

  51. J. Abraham Avelar‐Rivas

    Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional

    Affiliation as printed

    Unidad de Genómica Avanzada, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional , Km 9.6 Libramiento Norte Carretera Irapuato-León, 36824 , Irapuato ,

  52. Kyle K. Axt

    Oregon State University

    Affiliation as printed

    Department of Pharmaceutical Sciences, Oregon State University , 1601 SW Jefferson Way, Corvallis , OR 97331-3507 ,

  53. Hellen Bertoletti Barbieri

    Universidade Estadual de Campinas (UNICAMP)

    Affiliation as printed

    Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP) , Rua Monteiro Lobato 270, Campinas, São Paulo , 13.083-862,

  54. Júlio César Jerônimo Barbosa

    Universidade Estadual de Campinas (UNICAMP)

    Affiliation as printed

    Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP) , Rua Monteiro Lobato 270, Campinas, São Paulo , 13.083-862,

  55. Lucas Gabriel Barboza Segato

    University of Manitoba

    Affiliation as printed

    Department of Chemistry, University of Manitoba , 66 Chancellors Circle, Winnipeg , MB R3T 2N2 ,

  56. Susanna E. Barrett

    University of Illinois Urbana-Champaign · Carl R. Woese Institute for Genomic Biology

    Affiliation as printed

    Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign , 1206 W. Gregory Drive, Urbana , IL  61801 ,

    Department of Chemistry, University of Illinois Urbana-Champaign , 600 S. Matthews Ave, Urbana , IL  61801 ,

  57. Martin Baunach

    University of Bonn

    Affiliation as printed

    Institute of Pharmaceutical Biology, University of Bonn , Nussallee 6, 53115  Bonn ,

  58. Christine Beemelmanns

    Helmholtz Centre for Infection Research · Helmholtz Institute for Pharmaceutical Research Saarland · Saarland University

    Affiliation as printed

    Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,

    Saarland University, Campus E8.1 , 66123 Saarbrücken,

  59. Dardan Beqaj

    University of Tübingen

    Affiliation as printed

    Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Microbial Bioactive Compounds, University of Tübingen , Auf der Morgenstelle 28, 72076 , Tübingen,

  60. Tim Berger

    Philipps University of Marburg

    Affiliation as printed

    Institute of Pharmaceutical Biology and Biotechnology, University of Marburg , Robert-Koch-Str. 4, 35037  Marburg ,

  61. Jordan Bernaldo-Agüero

    National University of San Marcos · Universidad Nacional Autónoma de México

    Affiliation as printed

    Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001 , Chamilpa, 62210  Cuernavaca , Morelos ,

    Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos , Av. Germán Amézaga S/N, Ciudad Universitaria, UNMSM, Lima  15081 ,

    Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos , Av. Germán Amézaga S/N, Ciudad Universitaria, UNMSM, Lima  15081, Perú

  62. Sandra M Bettenbühl

    Goethe University Frankfurt · LOEWE Centre for Translational Biodiversity Genomics

    Affiliation as printed

    Institute for Molecular Bio Science, Goethe University Frankfurt , Max-von-Laue Strasse 9, 60438  Frankfurt am Main,

    LOEWE Center for Translational Biodiversity Genomics (TBG) , Senckenberganlage 25, 60325  Frankfurt am Main,

  63. Vincent A. Bielinski

    Universidade Federal do Rio de Janeiro

    Affiliation as printed

    Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro , Avenida Athos da Silveira Ramos, no 149, Rio de Janeiro, 21941 -909,

  64. Friederike Biermann

    Goethe University Frankfurt · LOEWE Centre for Translational Biodiversity Genomics · Wageningen University & Research

    Affiliation as printed

    Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,

    Institute for Molecular Bio Science, Goethe University Frankfurt , Max-von-Laue Strasse 9, 60438  Frankfurt am Main,

    LOEWE Center for Translational Biodiversity Genomics (TBG) , Senckenberganlage 25, 60325  Frankfurt am Main,

    WUR - Wageningen University and Research [Wageningen] (Droevendaalsesteeg 4, 6708 PB Wageningen - Netherlands)

  65. Ricardo Moraes Borges

    Universidade Federal do Rio de Janeiro

    Affiliation as printed

    Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro , CCS - Av. Carlos Chagas Filho, 373 - Bloco H - Cidade Universitária, Rio de Janeiro - RJ, 21941 -599,

  66. Rainer Borriss

    Universität Greifswald · Humboldt-Universität zu Berlin · Institute of Marine Biotechnology

    Affiliation as printed

    Department of Biology, Humboldt University Berlin , Invaliden-Str. 42, 10115  Berlin ,

    Institute of Marine Biotechnology (IMaB), University of Greifswald ,Walter-Rathenau-Str. 49A, 17489  Greifswald ,

  67. Milena Breitenbach

    Goethe University Frankfurt · LOEWE Centre for Translational Biodiversity Genomics

    Affiliation as printed

    Institute for Molecular Bio Science, Goethe University Frankfurt , Max-von-Laue Strasse 9, 60438  Frankfurt am Main,

    LOEWE Center for Translational Biodiversity Genomics (TBG) , Senckenberganlage 25, 60325  Frankfurt am Main,

  68. Kevin M. Bretscher Aachen Institute of Biology, Leiden University

    Leiden University · Netherlands Institute of Ecology · Instituto de Hortofruticultura Subtropical y Mediterránea "La Mayora"

    Affiliation as printed

    Department of Crop Protection, Instituto de Hortofruticultura Subtropical y Mediterránea “La Mayora” (IHSM-UMA-CSIC), Campus Universitario de Teatinos , 29010 , Málaga,

    Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW) , Droevendaalsesteeg 10 6708 PB Wageningen ,

    Institute of Biology, Leiden University , Sylviusweg 72, 2333BE  Leiden ,

    IBL - Institute Biology Leiden (Faculty of Science PO Box 9516 2300 RA Leiden - Netherlands)

  69. Michael W Brigham

    University of Leeds

    Affiliation as printed

    School of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Leeds , 6 Clarendon Way, Woodhouse, Leeds , LS2 3AA ,

  70. Larissa Buedenbender

    Universidade da Coruña

    Affiliation as printed

    CICA – Centro Interdisciplinar de Química e Bioloxía, Universidade da Coruña, As Carballeiras, s/n, Campus de Elviña , 15071 A Coruña,

  71. Brodie W. Bulcock

    The University of Western Australia

    Affiliation as printed

    School of Molecular Sciences, University of Western Australia , 35 Stirling Highway, Perth  6009 ,

    School of Molecular Sciences, The University of Western Australia, Perth 6009, Australia (Australia)

  72. Carolina Cano‐Prieto

    Novo Nordisk Foundation · Technical University of Denmark

    Affiliation as printed

    The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Building 220, Søltofts Plads, 2800 Kongens Lyngby,

  73. João Capela

    University of Minho

    Affiliation as printed

    Centre of Biological Engineering, University of Minho , 4710-057 , Braga ,

  74. Víctor J. Carrión Aachen Institute of Biology, Leiden University

    Leiden University · Instituto de Hortofruticultura Subtropical y Mediterránea "La Mayora" · Universidad de Málaga

    Affiliation as printed

    Department of Crop Protection, Instituto de Hortofruticultura Subtropical y Mediterránea “La Mayora” (IHSM-UMA-CSIC), Campus Universitario de Teatinos , 29010 , Málaga,

    Department of Microbiology, Faculty of Science, Campus Universitario de Teatinos s/n, University of Málaga , 29010 Málaga,

    Institute of Biology, Leiden University , Sylviusweg 72, 2333BE  Leiden ,

    IBL - Institute Biology Leiden (Faculty of Science PO Box 9516 2300 RA Leiden - Netherlands)

  75. Riley S. Carter

    University of Illinois Urbana-Champaign · Carl R. Woese Institute for Genomic Biology

    Affiliation as printed

    Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign , 1206 W. Gregory Drive, Urbana , IL  61801 ,

    Department of Chemistry, University of Illinois Urbana-Champaign , 600 S. Matthews Ave, Urbana , IL  61801 ,

  76. Raquel Castelo‐Branco

    Universidade do Porto · Centro Interdisciplinar de Investigação Marinha e Ambiental

    Affiliation as printed

    Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto , 4450-208  Matosinhos ,

  77. Gabriel Castro‐Falcón

    Scripps Institution of Oceanography · University of California San Diego

    Affiliation as printed

    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego , 9500 Gilman Drive, La Jolla , CA  92093-0212 ,

  78. Fernanda O. Chagas

    Universidade Federal do Rio de Janeiro

    Affiliation as printed

    Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro , CCS - Av. Carlos Chagas Filho, 373 - Bloco H - Cidade Universitária, Rio de Janeiro - RJ, 21941 -599,

  79. Esteban Charria‐Girón

    Helmholtz Centre for Infection Research · Technische Universität Braunschweig

    Affiliation as printed

    Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI) , Inhoffenstr. 7, 38124  Braunschweig ,

    Institute of Microbiology, Technische Universität Braunschweig , Spielmannstraße 7, 38106  Braunschweig ,

  80. Ayesha Ahmed Chaudhri

    Goethe University Frankfurt · LOEWE Centre for Translational Biodiversity Genomics

    Affiliation as printed

    Institute for Molecular Bio Science, Goethe University Frankfurt , Max-von-Laue Strasse 9, 60438  Frankfurt am Main,

    LOEWE Center for Translational Biodiversity Genomics (TBG) , Senckenberganlage 25, 60325  Frankfurt am Main,

  81. Vasvi Chaudhry

    University of Tübingen

    Affiliation as printed

    Microbial Interactions in Plant Ecosystems, IMIT/ZMBP, Eberhard Karls University of Tübingen , 72076 Tübingen,

  82. Hyukjae Choi

    Yeungnam University

    Affiliation as printed

    College of Pharmacy, Yeungnam University , 280 Daehak-ro Gyeongsan-Si, Gyeongsangbuk-do 38541 ,

    Research Institute of Cell Culture, Yeungnam University , 280 Daehak-ro Gyeongsan-Si, Gyeongsangbuk-do 38541 ,

  83. Yukyung Choi

    Sookmyung Women's University

    Affiliation as printed

    College of Pharmacy and Drug Information Research Institute, Sookmyung Women's University , 100 Cheongpa-ro 47 gil, Seoul  04310 ,

  84. Roya Choupannejad

    Westerdijk Fungal Biodiversity Institute

    Affiliation as printed

    Fungal Natural Products, Westerdijk Fungal Biodiversity Institute , Uppsalalaan 8, 3584CT  Utrecht ,

  85. Jakub Chromy

    University of Manchester

    Affiliation as printed

    Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, University of Manchester , 131 Princess Street, Manchester  M1 7DN ,

  86. Melinda S. Chue Donahey

    University of Florida

    Affiliation as printed

    Department of Microbiology and Cell Science, University of Florida , 1355 Museum Drive, Gainesville , Florida , 32611 ,

  87. Jérôme Collemare

    Westerdijk Fungal Biodiversity Institute

    Affiliation as printed

    Fungal Natural Products, Westerdijk Fungal Biodiversity Institute , Uppsalalaan 8, 3584CT  Utrecht ,

  88. Kaitlin E. Creamer

    Innovative Genomics Institute · University of California, Berkeley

    Affiliation as printed

    Department of Earth and Planetary Science, University of California , 307 McCone Hall Berkeley, CA  94720-4767 ,

    Innovative Genomics Institute, University of California Berkeley , 2151 Berkeley Way, Berkeley , CA  94720 ,

    EPS - Department of Earth and Planetary Science [UC Berkeley] (307 McCone Hall, Berkeley, CA 94720-4767 - United States)

  89. Max Crüsemann

    University of Bonn

    Affiliation as printed

    Institute of Pharmaceutical Biology, University of Bonn , Nussallee 6, 53115  Bonn ,

  90. Andrés Cumsille

    University of Florida

    Affiliation as printed

    Department of Microbiology and Cell Science, University of Florida , 1355 Museum Drive, Gainesville , Florida , 32611 ,

  91. Jean‐Félix Dallery

    Université Paris-Saclay · Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · Biologie et gestion des champignons phytopathogènes

    Affiliation as printed

    Université Paris-Saclay , INRAE, UR BIOGER, 22 place de l’Agronomie, 91120  Palaiseau ,

  92. Luis Caleb Damas-Ramos

    Novo Nordisk Foundation · Technical University of Denmark

    Affiliation as printed

    The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Building 220, Søltofts Plads, 2800 Kongens Lyngby,

  93. Tito Damiani

    Czech Academy of Sciences · Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

    Affiliation as printed

    IOCB Prague, Czech Academy of Science , Flemingovo náměstí 542/2, 160 00  Praha 6,

    IOCB / CAS - Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (Flemingovo namesti 2, 16610 Prague 6 - Czech Republic)

  94. Martinus de Kruijff

    Helmholtz Centre for Infection Research · Helmholtz Institute for Pharmaceutical Research Saarland

    Affiliation as printed

    Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,

  95. Gerardo Della Sala

    Stazione Zoologica Anton Dohrn

    Affiliation as printed

    Department of Ecosustainable Marine Biotechnology , Stazione Zoologica Anton Dohrn, Giardini del Molosiglio, Via A.F. Acton 55, 80133  Naples ,

  96. Jelle Dillen

    University of Antwerp

    Affiliation as printed

    Department of Bioscience Engineering, Research Group Laboratory of Applied Microbiology and Biotechnology, University of Antwerp , Groenenborgerlaan 171, 2020 Antwerp,

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