Brain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disorders
JCPP Advances, vol. 2
Abstract
Abstract Background To reduce suicide in females with mood disorders, it is critical to understand brain substrates underlying their vulnerability to future suicidal ideation and behaviors (SIBs) in adolescence and young adulthood. In an international collaboration, grey and white matter structure was investigated in adolescent and young adult females with future suicidal behaviors (fSB) and ideation (fSI), and without SIBs (fnonSIB). Methods Structural (n = 91) and diffusion‐weighted (n = 88) magnetic resonance imaging scans at baseline and SIB measures at follow‐up on average two years later (standard deviation, SD = 1 year) were assessed in 92 females [age(SD) = 16.1(2.6) years] with bipolar disorder (BD, 28.3%) or major depressive disorder (MDD, 71.7%). One‐way analyses of covariance comparing baseline regional grey matter cortical surface area, thickness, subcortical grey volumes, or white matter tensor‐based fractional anisotropy across fSB (n = 40, 43.5%), fSI (n = 33, 35.9%) and fnonSIB (n = 19, 20.6%) groups were followed by pairwise comparisons in significant regions (p < 0.05). Results Compared to fnonSIBs, fSIs and fSBs showed significant decreases in cortical thickness of right inferior frontal gyrus pars orbitalis and middle temporal gyrus, fSIs of left inferior frontal gyrus, pars orbitalis. FSIs and fSBs showed lower fractional anisotropy in left uncinate fasciculus and corona radiata, and fSBs in right uncinate and superior fronto‐occipital fasciculi. Conclusions The study provides preliminary evidence of grey and white matter alterations in brain regions subserving emotional and behavioral regulation and perceptual processing in adolescent and young adult females with mood disorders with, versus without, future SIBs. Findings suggest potential targets to prevent SIBs in female adolescents and young adults.
Authors 16
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Lejla Čolić corresponding
Yale University · Jena University Hospital · Deutsches Zentrum für Psychische Gesundheit
Affiliation as printed
Department of Psychiatry Yale School of Medicine New Haven Connecticut USA
Department of Psychiatry and Psychotherapy Jena University Hospital Jena Germany
German Center for Mental Health Jena Germany
Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
German Center for Mental Health, Jena, Germany
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Yale University · University of Oxford
Affiliation as printed
Department of Psychiatry University of Oxford Oxford UK
Department of Psychiatry Yale School of Medicine New Haven Connecticut USA
Department of Psychiatry, University of Oxford, Oxford, UK
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
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McGovern Institute for Brain Research · University of Cambridge · Massachusetts Institute of Technology · University of Birmingham
Affiliation as printed
Department of Psychiatry University of Cambridge Cambridge UK
Institute for Mental Health School of Psychology University of Birmingham Birmingham UK
McGovern Institute for Brain Research Massachusetts Institute of Technology Cambridge Massachusetts USA
Department of Psychiatry, University of Cambridge, Cambridge, UK
Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
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The University of Melbourne · Orygen
Affiliation as printed
Centre for Youth Mental Health The University of Melbourne Parkville Victoria Australia
Orygen Parkville Victoria Australia
Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia
Orygen, Parkville, Victoria, Australia
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Copenhagen University Hospital · Yale University
Affiliation as printed
Department of Neurology and Neurobiology Research Unit Copenhagen University Hospital Kobenhavn Denmark
Department of Psychiatry Yale School of Medicine New Haven Connecticut USA
Department of Neurology and Neurobiology Research Unit, Copenhagen University Hospital, Kobenhavn, Denmark
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
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Affiliation as printed
Department of Psychiatry Yale School of Medicine New Haven Connecticut USA
Interdepartmental Neuroscience Program Yale School of Medicine New Haven Connecticut USA
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, Connecticut, USA
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Yale University · University of Oxford
Affiliation as printed
Department of Psychiatry University of Oxford Oxford UK
Department of Psychiatry Yale School of Medicine New Haven Connecticut USA
Department of Psychiatry, University of Oxford, Oxford, UK
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
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Affiliation as printed
Department of Psychiatry Yale School of Medicine New Haven Connecticut USA
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
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Affiliation as printed
Department of Psychiatry Yale School of Medicine New Haven Connecticut USA
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
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Affiliation as printed
Department of Psychiatry Yale School of Medicine New Haven Connecticut USA
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
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Affiliation as printed
Department of Radiology and Biomedical Imaging Yale School of Medicine New Haven Connecticut USA
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA
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Affiliation as printed
Department of Psychiatry University of Cambridge Cambridge UK
Department of Psychiatry, University of Cambridge, Cambridge, UK
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Affiliation as printed
Department of Psychiatry University of Cambridge Cambridge UK
Department of Psychiatry, University of Cambridge, Cambridge, UK
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The University of Melbourne · Orygen
Affiliation as printed
Centre for Youth Mental Health The University of Melbourne Parkville Victoria Australia
Orygen Parkville Victoria Australia
Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia
Orygen, Parkville, Victoria, Australia
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Anne‐Laura van Harmelen Aachen Institute of Education and Child Studies Leiden University Leiden The Netherlands Institute of Education and Child Studies
Leiden University · University of Cambridge
Affiliation as printed
Department of Psychiatry University of Cambridge Cambridge UK
Institute of Education and Child Studies Leiden University Leiden The Netherlands
Department of Psychiatry, University of Cambridge, Cambridge, UK
Institute of Education and Child Studies, Leiden University, Leiden, The Netherlands
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Affiliation as printed
Child Study Center Yale School of Medicine New Haven Connecticut USA
Department of Psychiatry Yale School of Medicine New Haven Connecticut USA
Department of Radiology and Biomedical Imaging Yale School of Medicine New Haven Connecticut USA
Child Study Center, Yale School of Medicine, New Haven, Connecticut, USA
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA
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