From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer
Advanced Materials, vol. 33, pp. e2008094
Abstract
The tumor immune microenvironment (TIME) is comprised of a complex milieu that contributes to stunting antitumor immune responses by restricting T cells to accumulate in the vicinity of the tumor. Nanomedicine-based strategies are being proposed as a salvage effort to reinvigorate antitumor immunity. Various strategies, however, often fail to unleash the antitumor immune response because of the paucity of appropriate therapeutic targets in the complex TIME, invigorating a fervor of investigation into mechanisms underlying the TIME to resist nanomedicines. In this review article, effective nano/biomaterial-based delivery and TIME normalization approaches that promote T cell-mediated antitumor immune response will be discussed, with a focus on emerging preclinical and clinical strategies for immune normalization. Based on currently available evidence, it seems as if the ultimate success of cancer immunotherapy and nanomedicine hinges on the capacity to normalize the TIME. Here, how nanomedicines target immunosuppressive cells and signaling pathways to broaden the impact of cancer immunotherapy are explored. Acquisition of the urgently needed knowledge of nanomedicine-mediated immune normalization will guide researchers and scientists towards clinical applications of cancer immunotherapy.
Authors 8
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Chinese Academy of Sciences · Shanghai Institute of Materia Medica · State Key Laboratory of Drug Research
Affiliation as printed
State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences 501 Haike Road Shanghai 201203 China
State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203 China
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Chinese Academy of Sciences · Shanghai Institute of Materia Medica · State Key Laboratory of Drug Research
Affiliation as printed
State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences 501 Haike Road Shanghai 201203 China
State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203 China
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Chinese Academy of Sciences · Shanghai Institute of Materia Medica · State Key Laboratory of Drug Research
Affiliation as printed
State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences 501 Haike Road Shanghai 201203 China
State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203 China
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Yang Mei Shi Aachen Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging
Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering Faculty of Medicine RWTH Aachen University 52074 Aachen Germany
Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany
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Twan Lammers Aachen Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging
Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Department of Nanomedicine and Theranostics Institute for Experimental Molecular Imaging Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering Faculty of Medicine RWTH Aachen University 52074 Aachen Germany
Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany
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Ghent University · Cancer Research Institute Ghent
Affiliation as printed
Department of Pharmaceutics and Cancer Research Institute Ghent (CRIG) Ghent University Ghent 9000 Belgium
Department of Pharmaceutics and Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, 9000 Belgium
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Affiliation as printed
Australian Institute for Bioengineering and Nanotechnology The University of Queensland St. Lucia Queensland 4072 Australia
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, Queensland, 4072 Australia
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Haijun Yu corresponding
Chinese Academy of Sciences · Shanghai Institute of Materia Medica · State Key Laboratory of Drug Research
Affiliation as printed
State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences 501 Haike Road Shanghai 201203 China
State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203 China
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