A VersaTile-driven platform for rapid hit-to-lead development of engineered lysins

Science Advances, vol. 6, pp. eaaz1136

Abstract

in human serum and an ex vivo pig burn wound model. This generic platform could offer new opportunities to populate the preclinical pipeline with engineered lysins for diverse (therapeutic) applications.

Authors 8

1. Hans Gerstmans

   Ghent University · KU Leuven

   Affiliation as printed

   Department of Biosystems, KU Leuven, Kasteelpark Arenberg 21, 3001 Leuven, Belgium

   Department of Biosystems, KU Leuven, Willem de Croylaan 42, 3001 Leuven, Belgium

   Department of Biotechnology, Ghent University, Valentin Vaerwyckweg 1, 9000 Gent, Belgium

2. Dennis Grimon

   Ghent University

   Affiliation as printed

   Department of Biotechnology, Ghent University, Valentin Vaerwyckweg 1, 9000 Gent, Belgium

3. Cédric Lood

   KU Leuven

   Affiliation as printed

   Department of Biosystems, KU Leuven, Kasteelpark Arenberg 21, 3001 Leuven, Belgium

   Department of Microbial and Molecular Systems, KU Leuven, Kasteelpark Arenberg 23, 3001 Leuven, Belgium

4. Ana Rodrı́guez

   Consejo Superior de Investigaciones Científicas · Instituto de Productos Lácteos de Asturias

   Affiliation as printed

   Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC), Paseo Río Linares, s/n, 33300 Villaviciosa, Asturias, Spain

5. Vera van Noort Aachen Institute of Biology Leiden

   Leiden University · KU Leuven

   Affiliation as printed

   Department of Microbial and Molecular Systems, KU Leuven, Kasteelpark Arenberg 23, 3001 Leuven, Belgium

   Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 Leiden, Netherlands

6. Jeroen Lammertyn

   KU Leuven

   Affiliation as printed

   Department of Biosystems, KU Leuven, Willem de Croylaan 42, 3001 Leuven, Belgium

7. Rob Lavigne

   KU Leuven

   Affiliation as printed

   Department of Biosystems, KU Leuven, Kasteelpark Arenberg 21, 3001 Leuven, Belgium

8. Yves Briers corresponding

   Ghent University

   Affiliation as printed

   Department of Biotechnology, Ghent University, Valentin Vaerwyckweg 1, 9000 Gent, Belgium