Lessons Learned from Quantitative Dynamical Modeling in Systems Biology

• Towards a novel toxicity prediction pipeline, combining PBPK models and mechanistic cellular adversity models

  2026 Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  0

  citations
• Data-driven dynamic modelling identifies polyploidisation as key process in cell cycle progression upon DNA damage

  2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Cancer-related Molecular Pathways

  0

  citations
• Mathematical modelling reveals compound-specific stress pathway activity

  2025 Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  4

  citations
• Computational modelling identifies primary mediators of crosstalk between DNA damage and oxidative stress responses

  2025 PLoS Computational Biology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access

  3

  citations
• Model-based translation of DNA damage signaling dynamics across cell types

  2022 PLoS Computational Biology article Medicine Cancer-related Molecular Pathways Open access

  12

  citations
• Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-β signaling

  2022 PLoS Computational Biology article Biochemistry, Genetics and Molecular Biology Gene Regulatory Network Analysis Open access

  9

  citations
• Dynamic Modeling of Mitochondrial Membrane Potential Upon Exposure to Mitochondrial Inhibitors

  2021 Frontiers in Pharmacology article Biochemistry, Genetics and Molecular Biology Mitochondrial Function and Pathology Open access

  23

  citations

7 results