BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

• Imaging-based temporal dynamics of electrophile-induced NRF2 signaling in liver cells identifies adaptive versus adverse repeated exposure conditions

  2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress

  1

  citations
• Pharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC

  2025 Breast Cancer Research article Biochemistry, Genetics and Molecular Biology RNA Research and Splicing Open access

  5

  citations
• Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementia

  2023 Cell Death Discovery article Medicine Amyotrophic Lateral Sclerosis Research Open access

  17

  citations
• Identifying multiscale translational safety biomarkers using a network-based systems approach

  2023 iScience article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  14

  citations
• Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses

  2022 Toxicology in Vitro article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access

  8

  citations
• Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure

  2022 Scientific Reports article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access

  31

  citations
• High-content high-throughput imaging reveals distinct connections between mitochondrial morphology and functionality for OXPHOS complex I, III, and V inhibitors

  2022 Cell Biology and Toxicology article Biochemistry, Genetics and Molecular Biology Mitochondrial Function and Pathology Open access

  19

  citations
• Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals

  2022 Toxicology in Vitro article Environmental Science Effects and risks of endocrine disrupting chemicals Open access

  2

  citations
• Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action

  2021 Toxicology in Vitro article Veterinary Animal testing and alternatives Open access

  39

  citations
• Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages

  2021 Archives of Toxicology article Biochemistry, Genetics and Molecular Biology Heme Oxygenase-1 and Carbon Monoxide Open access

  23

  citations
• Pathomechanisms of ALS8: altered autophagy and defective RNA binding protein (RBP) homeostasis due to the VAPB P56S mutation

  2021 Cell Death and Disease article Medicine Amyotrophic Lateral Sclerosis Research Open access

  25

  citations
• Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds

  2021 Toxicological Sciences article Biochemistry, Genetics and Molecular Biology Estrogen and related hormone effects Open access

  11

  citations
• Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling

  2021 EMBO Reports article Biochemistry, Genetics and Molecular Biology Heat shock proteins research Open access

  84

  citations
• Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention

  2021 Journal of Experimental & Clinical Cancer Research article Biochemistry, Genetics and Molecular Biology RNA Research and Splicing Open access cited by 1 patent

  73

  citations
• In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment

  2021 Small article Biochemistry, Genetics and Molecular Biology Carcinogens and Genotoxicity Assessment Open access

  49

  citations
• ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response

  2020 iScience article Biochemistry, Genetics and Molecular Biology Endoplasmic Reticulum Stress and Disease Open access

  143

  citations

16 results