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Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives2020 European Journal of Medicinal Chemistry article Biochemistry, Genetics and Molecular Biology Ion channel regulation and function Open access
Jacobus P. D. van Veldhoven, Giulia Campostrini, Constantijn J.E. van Gessel, Dorien Ward‐van Oostwaard, Rongfang Liu, Christine L. Mummery, +2 more
8citations -
Mining a human transcriptome database for chemical modulators of NRF22020 PLoS ONE article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
John P. Rooney, Brian N. Chorley, Steven W. Hiemstra, Steven Wink, Xuting Wang, Douglas A. Bell, +2 more
54citations -
Extracellular binding sites of positive and negative allosteric P2X4 receptor modulators2022 Life Sciences article Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling
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19citations -
Combining Switchable Phase‐Change Materials and Phase‐Transition Materials for Thermally Regulated Smart Mid‐Infrared Modulators2021 Advanced Optical Materials article Materials Science Phase-change materials and chalcogenides Open access
Andreas Heßler, Xiao Wang, Yunzhen Cao, Lixin Song, Alfred Ludwig, Matthias Wuttig, +1 more
46citations -
In Silico and Experimental ADAM17 Kinetic Modeling as Basis for Future Screening System for Modulators2022 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Protease and Inhibitor Mechanisms Open access cited by 1 patent
Marian Bienstein, Dmitriy Minond, Ulrich Schwaneberg, Mehdi D. Davari, Daniela Yildiz
13citations -
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease2023 Journal of Medicinal Chemistry article Neuroscience Genetic Neurodegenerative Diseases Open access
Longbin Liu, Karine Malagu, Alan F. Haughan, Vinod K. Khetarpal, Andrew J. Stott, William Esmieu, +41 more
8citations -
Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators2026 Advanced Science article Biochemistry, Genetics and Molecular Biology TGF-β signaling in diseases Open access
Maarten van Dinther, Tristin A. Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, +8 more
1citations -
Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease2025 Clinical and Molecular Hepatology article Medicine Liver Disease Diagnosis and Treatment Open access
Oveis Jamialahmadi, Endrina Mújica, Lowri Morris, Rosellina Margherita Mancina, Ester Ciociola, Samantha Maurotti, +14 more
10citations -
Mechano-Pharmacological Testing of L-Type Ca2+ Channel Modulators via Human Vascular Celldrum Model2020 Cellular Physiology and Biochemistry article Biochemistry, Genetics and Molecular Biology Cellular Mechanics and Interactions Open access
Robin Bayer, Ilya Digel, Julia Falkenstein, G.M. Artmann, Till Creutz
1citations -
Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases2020 International Journal of Molecular Sciences article Medicine Amyotrophic Lateral Sclerosis Research Open access
Alejandro Federico De Nicola, María Meyer, Rachida Guennoun, Michaël Schumacher, Hazel Hunt, Joseph K. Belanoff, +2 more
41citations -
Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death2021 Computational and Structural Biotechnology Journal article Neuroscience Genetic Neurodegenerative Diseases Open access
Michael A. Margreiter, Monika Witzenberger, Yasmine Wasser, Elena Davydova, Robert Janowski, Jonas Metz, +12 more
19citations -
Identification of kinase modulators as host-directed therapeutics against intracellular methicillin-resistant Staphylococcus aureus2024 Frontiers in Cellular and Infection Microbiology article Medicine Antimicrobial Resistance in Staphylococcus Open access
Robin H. G. A. van den Biggelaar, Kimberley V. Walburg, Susan J. F. van den Eeden, Cassandra L. R. van Doorn, Eugenia Meiler, Alex S. de Ries, +3 more
9citations -
OS02-09 Identification of Novel NRF2 Pathway Modulators via High-Throughput RNAi Screening and Their Role in Protection from Oxidative Stress-Induced Cell Death2026 Toxicology Letters article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress
S. Aslan, S.W. Hiemstra, L.S. Wijaya, M. Niemeijer, B. Herpers, I.M. Copple, +3 more
0citations -
Adenosine receptors in GtoPdb v.2025.42025 IUPHAR/BPS Guide to Pharmacology CITE article Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling Open access
Bertil B. Fredholm, Ulrich Schwabe, Lauren Therese May, Christa Elisabeth Müller, Joel M Linden, Karl‐Norbert Klotz, +5 more
0citations -
Cholinergic Modulation of Disorder-Relevant Neural Circuits in Generalized Anxiety Disorder2020 Biological Psychiatry article Psychology Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Open access
Toby Wise, Fiona Patrick, Nicholas Meyer, Ndaba Mazibuko, Alice E. Oates, Anne H. M. van der Bijl, +9 more
29citations