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Integration of in vitro and in silico approaches enables prediction of drug-induced liver injury2026 Archives of Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
René Geci, Ahenk Zeynep Sayin, Stephan Schaller, Lars Kuepfer
5citations -
Integration of In Vitro and In Silico Approaches Enables Prediction of Drug-Induced Liver Injury2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
René Geci, Ahenk Zeynep Sayin, Stephan Schaller, Lars Kuepfer
0citations -
Mechanism-based drug safety testing using innovative in vitro liver models: from DILI prediction to idiosyncratic DILI liability assessment2025 Expert Opinion on Drug Metabolism & Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Sibel Bahtiri, Tessa M. S. Hagens, Bob van de Water, Marije Niemeijer
3citations -
Keep looking at the negative side: improved detection of drug-induced liver injury with non-hepatotoxicant data oversampling2025 ChemRxiv preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Olivier J. M. Béquignon, Steven Wink, Steven W. Hiemstra, J. E. Fokkelman-Klip, Wouter den Hollander, Giulia Callegaro, +2 more
0citations -
Keep looking at the negative side: improved detection of drug-induced liver injury with non-hepatotoxicant data oversampling2025 ChemRxiv preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Olivier J. M. Béquignon, Steven Wink, Steven W. Hiemstra, J. E. Fokkelman-Klip, Wouter den Hollander, Giulia Callegaro, +2 more
0citations -
Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury2021 Biochemical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Lukas S. Wijaya, Panuwat Trairatphisan, Attila Gábor, Marije Niemeijer, Jason Keet, Ariadna Alcalà Morera, +13 more
27citations -
Elevated APRI/ALBI score can predict postoperative complications after resection of colorectal liver metastases, in patients undergoing preoperative chemotherapy2024 Zeitschrift für Gastroenterologie article Medicine Inflammatory Biomarkers in Disease Prognosis
Gerrit Josephs, Alexandros Chrysos, Robert Malte Siepmann, Daniel Truhn, Theresa Hildegard Wirtz, Tom Lüdde, +3 more
0citations -
P18-72 Integration of Metabolomics and Transcriptomics, as well as Mitostress, CALUX Assays and Targeted Proteomics for an Improved Mechanism-based Hazard Characterization of Drug-induced Liver Injury2025 Toxicology Letters article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection
Franziska Maria Zickgraf, Lukas S. Wijaya, T. de Boer, Sofia Moco, Victoria Pozo Garcia, Oliver Pötz, +5 more
0citations -
Splenic hypertrophy predicts liver-specific complications in patients undergoing major liver resection for colorectal liver metastases, after preoperative chemotherapy2024 HepatoBiliary Surgery and Nutrition article Medicine Colorectal Cancer Treatments and Studies Open access
Gerrit Josephs, Lea Hitpaß, Daniel Truhn, F. Meister, Marie‐Luise Berres, Tom Luedde, +5 more
2citations -
Towards a novel toxicity prediction pipeline, combining PBPK models and mechanistic cellular adversity models2026 Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Elsje J Burgers, Raju P. Sharma, Tamara Y Danilyuk, Sem Vogel, Lukas S. Wijaya, Marcel Leist, +5 more
0citations -
Real-World Use of Terlipressin in Cirrhosis and Acute Kidney Injury: Frequent Use Beyond Hepatorenal Syndrome2025 Clinical Gastroenterology and Hepatology article Medicine Liver Disease and Transplantation Open access
Ann Thu Ma, Adrià Juanola, Kavish Rohit Patidar, Anna Barone, Simone Incicco, Anand V. Kulkarni, +68 more
5citations -
Towards Bayesian-based quantitative adverse outcome pathways using in vitro data from open literature and continuous variables: a case example for liver fibrosis2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Robin Durník, Tereza Juchelková, Helge Hecht, Levi M. T. Winkelman, Joost B. Beltman, Xavier Coumoul, +4 more
0citations -
Towards Bayesian-based quantitative adverse outcome pathways using in vitro data from open literature and continuous variables: a case example for liver fibrosis2026 Toxicological Sciences article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Robin Durník, Tereza Juchelková, Helge Hecht, Levi M. T. Winkelman, Joost B. Beltman, Xavier Coumoul, +4 more
0citations