Papers matching “in vitro toxicity prediction” 53
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Integration of in vitro and in silico approaches enables prediction of drug-induced liver injury2026 Archives of Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
René Geci, Ahenk Zeynep Sayin, Stephan Schaller, Lars Kuepfer
5citations -
Integration of In Vitro and In Silico Approaches Enables Prediction of Drug-Induced Liver Injury2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
René Geci, Ahenk Zeynep Sayin, Stephan Schaller, Lars Kuepfer
0citations -
P30-49 Hazard assessment of endocrine disruption potential using new alternative methods: integration of in vitro thyroid peroxidase inhibition potency and metabolic fate of 3-amino-2,6-dimethylphenol explains its lack of thyroid toxicity in vivo2025 Toxicology Letters article Environmental Science Effects and risks of endocrine disrupting chemicals Open access
Karma C. Fussell, Sjoerd Verkaart, Joris van den Elzen, N. Pineiro Costas, Brunhilde Blömeke, Mira Wenker, +1 more
0citations -
Identification of mitochondrial toxicants by combined in silico and in vitro studies – A structure-based view on the adverse outcome pathway2020 Computational Toxicology article Computer Science Computational Drug Discovery Methods Open access
Florentina Troger, Johannes Delp, Melina Funke, Wanda van der Stel, Claire Colas, Marcel Leist, +2 more
22citations -
Estimated Dermal Penetration of Tetrachlorvinphos (TCVP) in Humans Based on In Silico Modeling and In Vitro and In Vivo Data2023 Journal of Toxicology and Environmental Health article Agricultural and Biological Sciences Pesticide Exposure and Toxicity
William G. Reifenrath, John H. Ross, Wilfred Maas, Jeffrey Driver, Michael J. Bartels
1citations -
Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells2023 Journal of Chemical Information and Modeling article Computer Science Computational Drug Discovery Methods Open access
Olivier J. M. Béquignon, José Carlos Gómez-Tamayo, Eelke Bart Lenselink, Steven Wink, Steven W. Hiemstra, Chi Chung Lam, +6 more
3citations -
Towards Bayesian-based quantitative adverse outcome pathways using in vitro data from open literature and continuous variables: a case example for liver fibrosis2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Robin Durník, Tereza Juchelková, Helge Hecht, Levi M. T. Winkelman, Joost B. Beltman, Xavier Coumoul, +4 more
0citations -
Towards Bayesian-based quantitative adverse outcome pathways using in vitro data from open literature and continuous variables: a case example for liver fibrosis2026 Toxicological Sciences article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Robin Durník, Tereza Juchelková, Helge Hecht, Levi M. T. Winkelman, Joost B. Beltman, Xavier Coumoul, +4 more
0citations -
Towards a novel toxicity prediction pipeline, combining PBPK models and mechanistic cellular adversity models2026 Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Elsje J Burgers, Raju P. Sharma, Tamara Y Danilyuk, Sem Vogel, Lukas S. Wijaya, Marcel Leist, +5 more
0citations -
Multi-omics phenotyping of the gut-liver axis allows health risk predictability from in vivo subchronic toxicity tests of a low-dose pesticide mixture2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Agricultural and Biological Sciences Pesticide Exposure and Toxicity Open access
Robin Mesnage, Maxime Teixeira, Daniele Mandrioli, Laura Falcioni, Quinten R. Ducarmon, Romy Daniëlle Zwittink, +7 more
5citations -
Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides2022 Nucleic Acid Therapeutics article Biochemistry, Genetics and Molecular Biology RNA Interference and Gene Delivery Open access cited by 3 patents
Aurélie Goyenvalle, Cecilia Jimenez-Mallebrera, Willeke van Roon‐Mom, Sabine Sewing, Arthur Μ. Krieg, Virginia Arechavala‐Gomeza, +1 more
94citations -
Systematic Evaluation of High-Throughput PBK Modelling Strategies for the Prediction of Intravenous and Oral Pharmacokinetics in Humans2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Computer Science Computational Drug Discovery Methods Open access
René Geci, Domenico Gadaleta, Marina García de Lomana, Rita Ortega-Vallbona, Erika Colombo, Eva Serrano‐Candelas, +3 more
0citations -
Biosafety of two-dimensional molybdenum disulfide nanomaterials: Natural and engineered transformation pathways and their role in the toxicity profile2023 Critical Reviews in Environmental Science and Technology article Engineering Graphene and Nanomaterials Applications Open access
Kailun Sun, Erkai He, Cornelis A.M. van Gestel, Xinde Cao, Ling Zhao, Xiaoyun Xu, +2 more
9citations -
Exploring the Antimycobacterial Potential of Podocarpusflavone A from Kielmeyera membranacea: In Vitro and In Vivo Insights2024 Pharmaceuticals article Biochemistry, Genetics and Molecular Biology Biological Activity of Diterpenoids and Biflavonoids Open access
Marlon Heggdorne de Araújo, Salomé Muñoz Sánchez, Thatiana Lopes Biá Ventura Simão, Natalia Nowik, Stella Schuenck Antunes, Shaft Corrêa Pinto, +8 more
0citations -
Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans2024 Archives of Toxicology article Computer Science Computational Drug Discovery Methods Open access
René Geci, Domenico Gadaleta, Marina García de Lomana, Rita Ortega-Vallbona, Erika Colombo, Eva Serrano‐Candelas, +3 more
33citations -
Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD2024 Genome Medicine article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Jonathan Emanuel Knikman, Qinglian Zhai, Carin A.T.C. Lunenburg, Linda M. Henricks, Stefan Böhringer, Maaike van der Lee, +22 more
13citations -
A simplified co-culture reveals altered cardiotoxic responses to doxorubicin in hPSC-derived cardiomyocytes in the presence of endothelial cells2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Chemotherapy-induced cardiotoxicity and mitigation Open access
Marcella Brescia, Andrea Chatrian, Paul Keselman, James Gallant, Elsa Sorman Paulsson, Mervyn P.H. Mol, +10 more
1citations