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Hepatitis C virus cell culture adaptive mutations enhance cell culture propagation by multiple mechanisms but boost antiviral responses in primary human hepatocytes2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Hepatitis C virus research Open access
Nicola Frericks, Richard J. P. Brown, Birthe M. Reinecke, Maike Herrmann, Yannick Brüggemann, Daniel Tödt, +5 more
1citations -
Transcriptomic mapping of the inter-individual variability of cellular stress response activation in primary human hepatocytes2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Marije Niemeijer, Witold Więcek, Suzanna Huppelschoten, Peter Bouwman, Audrey Baze, Celine Parmentier, +4 more
3citations -
Systematic comparison of temporal transcriptional responses to hepatotoxicants in primary human hepatocytes and HepaRG cells using concentration-response modelling of gene co-expression networks2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Steven J. Kunnen, Emma Arnesdotter, Christian Tobias Willenbockel, Mathieu Vinken, Bob van de Water
0citations -
Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosis2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Microtubule and mitosis dynamics Open access
Gabriella Darmasaputra, Susana M. Chuva de Sousa Lopes, Hans C. Clevers, Matilde Galli
2citations -
The human hepatocyte TXG-MAPr: WGCNA transcriptomic modules to support mechanism-based risk assessment2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Giulia Callegaro, Steven J. Kunnen, Panuwat Trairatphisan, Solène Grosdidier, Marije Niemeijer, Wouter den Hollander, +9 more
1citations -
Deconvolution of cellular subsets in human tissue based on targeted DNA methylation analysis at individual CpG sites2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Epigenetics and DNA Methylation Open access
Marco F. Schmidt, Tiago Maié, Edgar Dahl, Ivan G. Costa, Wolfgang Wagner
2citations -
Scalable production of tissue-like vascularised liver organoids from human PSCs2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access cited by 1 patent
Sean Philip Harrison, Richard Siller, Yoshiaki Tanaka, Yangfei Xiang, Benjamin Patterson, Henning Kempf, +22 more
12citations -
Fast and efficient generation of knock-in human organoids using homology-independent CRISPR/Cas9 precision genome editing2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 15 patents
Benedetta Artegiani, Delilah F. G. Hendriks, Joep Beumer, Rutger N.U. Kok, Xuan Zheng, Indi P. Joore, +4 more
29citations -
Modulation of host signalling pathways reveal a major role for Wnt signalling in the maturation of Plasmodium falciparum liver schizonts2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Malaria Research and Control Open access
Abhishek Kanyal, Geert‐Jan van Gemert, Haoyu Wu, Alex van der Starre, Johannes H.W. de Wilt, Teun Bousema, +3 more
0citations -
Oncofetal protein CRIPTO regulates wound healing and fibrogenesis in regenerating liver and is associated with the initial stages of cardiac fibrosis2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Liver physiology and pathology Open access
Sofia Karkampouna, Danny van der Helm, Bart van Hoek, Hein W. Verspaget, Marie‐José Goumans, Minneke J. Coenraad, +2 more
2citations -
TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in CMS4 colorectal cancer subtype2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology TGF-β signaling in diseases Open access
Tom J. Harryvan, Subinuer Abudukelimu, Imke Stouten, EJ van der Wel, Kristiaan Lenos, OJ Sansom, +1 more
0citations -
The proteomic landscape of proteotoxic stress in a fibrogenic liver disease2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Chemistry Advanced Proteomics Techniques and Applications Open access
Florian A. Rosenberger, Sophia Clara Mädler, Katrine Holtz Thorhauge, Sophia Steigerwald, Malin Fromme, Caroline A M Weiss, +13 more
2citations -
The immediate cellular response to whole-genome doubling is conserved across polyploid contexts2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Agricultural and Biological Sciences Chromosomal and Genetic Variations Open access
Cindy C. Geerlings, Gabriella Darmasaputra, Christa Jordan Ortiz, Susana M. Chuva de Sousa Lopes, Hans C. Clevers, Matilde Galli
0citations -
Single-Cell Resolution of Cellular Damage Illuminates Disease Progression2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Single-cell and spatial transcriptomics Open access
Tsimafei Padvitski, Paula Unger Avila, He Chen, Fabian Braun, David Unnersjö‐Jess
1citations -
Intercellular crosstalk regulating ARRB2/RARRES1 is involved in transition from fibrosis to cancer2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Liver physiology and pathology Open access
Robert Schierwagen, Peter Dietrich, Judith Heinzen, Sabine Klein, Frank Erhard Uschner, Cristina Ortiz, +25 more
0citations -
Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis2021 medRxiv preprint Immunology and Microbiology Atherosclerosis and Cardiovascular Diseases Open access
Lotte Slenders, Lennart P. L. Landsmeer, Kai Cui, Marie A.C. Depuydt, Maarten C. Verwer, Joost M. Mekke, +17 more
4citations -
Targeting PTRAMP-CSS potently inhibits P. falciparum across blood, liver and mosquito stages2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Malaria Research and Control Open access
Pailene S. Lim, Nicolai C Jung, Mikha Gabriela, Jelte M. M. Krol, Kitsanapong Reaksudsan, Myo T. Naung, +12 more
0citations
19 results