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Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase2024 The Journal of Cell Biology article Biochemistry, Genetics and Molecular Biology Microtubule and mitosis dynamics Open access
Gabriella S. Darmasaputra, Cindy C. Geerlings, Susana M. Chuva de Sousa Lopes, Hans C. Clevers, Matilde Galli
15citations -
Hepatitis C virus cell culture adaptive mutations enhance cell culture propagation by multiple mechanisms but boost antiviral responses in primary human hepatocytes2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Hepatitis C virus research Open access
Nicola Frericks, Richard J. P. Brown, Birthe M. Reinecke, Maike Herrmann, Yannick Brüggemann, Daniel Tödt, +5 more
1citations -
Transcriptomic mapping of the inter-individual variability of cellular stress response activation in primary human hepatocytes2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Marije Niemeijer, Witold Więcek, Suzanna Huppelschoten, Peter Bouwman, Audrey Baze, Celine Parmentier, +4 more
3citations -
Systematic comparison of temporal transcriptional responses to hepatotoxicants in primary human hepatocytes and HepaRG cells using concentration-response modelling of gene co-expression networks2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Steven J. Kunnen, Emma Arnesdotter, Christian Tobias Willenbockel, Mathieu Vinken, Bob van de Water
0citations -
Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes2021 Toxicology in Vitro article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Bas ter Braak, Marije Niemeijer, Ruben Boon, Celine Parmentier, Audrey Baze, Lysiane Richert, +4 more
14citations -
Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors2024 Environmental Health Perspectives article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Marije Niemeijer, Witold Więcek, Shuai Fu, Suzanna Huppelschoten, Peter Bouwman, Audrey Baze, +5 more
16citations -
Discrimination of Steatotic and Non-Steatotic Chemicals Through Transcriptome Analysis in Primary Human Hepatocytes2026 International Journal of Molecular Sciences article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Christina A. Cramer von Clausbruch, Marcha C. T. Verheijen, Giulia Callegaro, Jonathan H. Freedman, Rita Ortega-Vallbona, Martina Palomino‐Schätzlein, +2 more
1citations -
Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosis2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Microtubule and mitosis dynamics Open access
Gabriella Darmasaputra, Susana M. Chuva de Sousa Lopes, Hans C. Clevers, Matilde Galli
2citations -
MicroRNAs modulate SARS ‐ CoV ‐2 infection of primary human hepatocytes by regulating the entry factors ACE2 and TMPRSS22024 Liver International article Biochemistry, Genetics and Molecular Biology MicroRNA in disease regulation Open access
Rajendra Khanal, Natalie Heinen, Alexandra Bogomolova, Toni Luise Meister, Simon T. Herrmann, Saskia Westhoven, +11 more
4citations -
Transcriptomic profiling of the inter-individual variability of chemical-induced cellular stress response activation in primary human hepatocytes2021 Toxicology Letters article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection
Marije Niemeijer, Witold Więcek, S. Huppelschoten, Audrey Baze, Celine Parmentier, Lysiane Richert, +3 more
0citations -
Correction to: Toxicogenomics directory of chemically exposed human hepatocytes2022 Archives of Toxicology erratum Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Marianna Grinberg, Regina M. Stöber, Karolina Edlund, Eugen Rempel, Patrício Godoy, Raymond Reif, +35 more
0citations -
Evaluation of in vitro liver models and non-human primates for predicting ADAR RNA editing efficiency in human liver2025 Scientific Reports article Biochemistry, Genetics and Molecular Biology RNA regulation and disease Open access
Mònica Aguilà, Nicole H.P. Cnubben, David A. Parfitt, Bruno Albuquerque, Peter C. de Visser, Marlieke Molendijk, +1 more
0citations -
Comparing in vitro human liver models to in vivo human liver using RNA-Seq2020 Archives of Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access cited by 1 patent
Yannick Schrooders, Duncan A. Hauser, Marcel van Herwijnen, Wiebke Albrecht, Bas ter Braak, Tim Brecklinghaus, +17 more
100citations -
A comparison between different human hepatocyte models reveals profound differences in net glucose production, lipid composition and metabolism in vitro2024 Experimental Cell Research article Biochemistry, Genetics and Molecular Biology Metabolism, Diabetes, and Cancer Open access
Flavio Bonanini, Madhulika Singh, Hong Yang, Dorota Kurek, Amy C. Harms, Adil Mardinoğlu, +1 more
12citations -
The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment2021 Archives of Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Giulia Callegaro, Steven J. Kunnen, Panuwat Trairatphisan, Solène Grosdidier, Marije Niemeijer, Wouter den Hollander, +9 more
43citations -
The human hepatocyte TXG-MAPr: WGCNA transcriptomic modules to support mechanism-based risk assessment2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Giulia Callegaro, Steven J. Kunnen, Panuwat Trairatphisan, Solène Grosdidier, Marije Niemeijer, Wouter den Hollander, +9 more
1citations -
Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models2025 Toxicology in Vitro article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Tamara Meijer, Bas ter Braak, Liesanne Wolters, Steven J. Kunnen, Barira Islam, Ilinca Suciu, +8 more
3citations