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LXR Agonist T0901317′s Hepatic Impact Overrules Its Atheroprotective Action in Macrophages, Driving Early Atherogenesis in Chow-Diet-Fed Male Apolipoprotein E Knockout Mice
Menno Hoekstra, Laura M. de Jong, Rick van der Geest, Lidewij R. de Leeuw, Rani Krisnamurthi, Janine J. Geerling, +1 more
6citations -
Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages☆2020 Journal of Hepatology article Medicine Liver Disease Diagnosis and Treatment Open access cited by 2 patents
Sander Lefere, Tobias Puengel, Jana Hundertmark, Christian Penners, Anna Katharina Frank, Adrien Guillot, +9 more
315citations -
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches2022 Cell article Biochemistry, Genetics and Molecular Biology Single-cell and spatial transcriptomics Open access cited by 4 patents
Martin Guilliams, Johnny Bonnardel, Birthe Haest, Bart Vanderborght, Camille Wagner, Anneleen Remmerie, +31 more
1,021citations -
Roles of CCR2 and CCR5 for Hepatic Macrophage Polarization in Mice With Liver Parenchymal Cell-Specific NEMO Deletion2020 Cellular and Molecular Gastroenterology and Hepatology article Medicine Liver physiology and pathology Open access
Matthias Bartneck, Christiane Koppe, Viktor Fech, Klaudia Theresa Warzecha, Marlene Sophia Kohlhepp, Sebastian Huss, +4 more
44citations -
PRMT5 inhibition induces pro‐inflammatory macrophage polarization and increased hepatic triglyceride levels without affecting atherosclerosis in mice2023 Journal of Cellular and Molecular Medicine article Biochemistry, Genetics and Molecular Biology Cancer-related gene regulation Open access
Yiheng Zhang, Robin A.F. Verwilligen, Miranda Van Eck, Menno Hoekstra
15citations -
Spatial proteogenomics reveals distinct and evolutionarily-conserved hepatic macrophage niches2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Single-cell and spatial transcriptomics Open access
Martin Guilliams, Johnny Bonnardel, Birthe Haest, Bart Vanderborght, Anna Bujko, Liesbet Martens, +30 more
97citations -
Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA2025 Advanced Science article Biochemistry, Genetics and Molecular Biology RNA Interference and Gene Delivery Open access
Cheng Lin, Adrian Kuzmanović, Nan Wang, Liangliang Liao, Sabrina Ernst, Christian Penners, +16 more
6citations -
Sulforaphane regulates hepatic autophagy and apoptosis by modulating Kupffer cells’ polarization via Nrf2/HO-1 pathway in the murine hemorrhagic shock/resuscitation model2025 European Journal of Trauma and Emergency Surgery article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress
Athanassios Fragoulis, Weining Yan, Xing Zhang, Qun Zhao, Chunxia Ma, Zhizhen He, +3 more
4citations -
Totum-448, a polyphenol-rich plant extract, decreases hepatic steatosis and inflammation in diet-induced MASLD mice2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Liver Disease Diagnosis and Treatment Open access
Joost M. Lambooij, Vivien Chavanelle, Marie Vallier, Hendrik J.P. van der Zande, Yolanda F. Otero, Frank Otto, +7 more
0citations -
FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Liver Disease Diagnosis and Treatment Open access
Cong Liu, Milena Schönke, Borah Spoorenberg, Joost M. Lambooij, Hendrik J.P. van der Zande, Enchen Zhou, +12 more
8citations -
Macrophage migration inhibitory factor predicts an unfavorable outcome after transarterial chemoembolization for hepatic malignancies2021 Clinical and Translational Science article Immunology and Microbiology Macrophage Migration Inhibitory Factor Open access
Theresa Hildegard Wirtz, Sven Heiko Loosen, Max Schulze‐Hagen, Joao Gorgulho, Jennis Kandler, Markus S. Joerdens, +9 more
13citations -
Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats2020 International Journal of Molecular Sciences article Medicine Liver Disease Diagnosis and Treatment Open access
Carla Cremonese, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Olaf Tyc, Cristina Ortiz, +9 more
9citations -
Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis2022 International Journal of Molecular Sciences article Medicine Liver Disease Diagnosis and Treatment Open access
Tobias Puengel, Sander Lefere, Jana Hundertmark, Marlene Sophia Kohlhepp, Christian Penners, Frederique Van de Velde, +10 more
59citations