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Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessment2022 Journal of Pharmacological and Toxicological Methods article Medicine Cardiac electrophysiology and arrhythmias Open access
Michael K. Pugsley, Yevgeniya E. Koshman, Tessa de Korte, Simon Authier, Brett R. Winters, Michael J. Curtis
2citations -
CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations—Implication for Drug Safety, Dosing, and Individualized Therapy2021 Frontiers in Genetics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Immaculate Mbongo Langmia, Katja Susanne Just, Sabrina Yamoune, Jürgen Brockmöller, Collen Mutowembwa Masimirembwa, Julia Stingl
95citations -
Improving medication safety in the Intensive Care by identifying relevant drug-drug interactions - Results of a multicenter Delphi study2020 Journal of Critical Care article Medicine Pharmaceutical Practices and Patient Outcomes Open access
Tinka Bakker, Joanna Ewa Klopotowska, Nicolette F. de Keizer, Rob J. van Marum, Heleen van der Sijs, Dylan W. de Lange, +28 more
30citations -
Cardiovascular Safety Profile of Romosozumab: A Pharmacovigilance Analysis of the US Food and Drug Administration Adverse Event Reporting System (FAERS)2021 Journal of Clinical Medicine article Pharmacology, Toxicology and Pharmaceutics Pharmacovigilance and Adverse Drug Reactions Open access
Annika Vestergaard Kvist, Junaid Faruque, Enriqueta Vallejo‐Yagüe, Stefan Weiler, Elizabeth Martha Winter, Andrea Michelle Burden
88citations -
10 clinical tips for advancing patient safety when using syringe pump systems for microinfusion intravenous drug therapy2023 European Journal of Anaesthesiology article Engineering Intravenous Infusion Technology and Safety Open access
Markus Weiß, Anne Catherine van der Eijk, Per‐Arne Lönnqvist, Alberto Lucchini, Annemoon Timmerman
10citations -
Safety of Anthroposophic Medicinal Products: An Analysis of Adverse Drug Reactions from German Pharmacovigilance Databases2021 Drugs - Real World Outcomes article Medicine Complementary and Alternative Medicine Studies Open access
Miek C. Jong, Herman van Wietmarschen, Anja Glockmann, Erik Wim Baars, Harald Johan Hamre
5citations -
An innovative method to strengthen evidence for potential drug safety signals using Electronic Health Records2024 Journal of Medical Systems article Pharmacology, Toxicology and Pharmaceutics Pharmacovigilance and Adverse Drug Reactions Open access
Hanieh Abedian Kalkhoran, J. Zwaveling, Florence P. A. M. van Hunsel, Agnes C Kant
16citations -
Mechanism-based drug safety testing using innovative in vitro liver models: from DILI prediction to idiosyncratic DILI liability assessment2025 Expert Opinion on Drug Metabolism & Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Sibel Bahtiri, Tessa M. S. Hagens, Bob van de Water, Marije Niemeijer
3citations -
Pharmacogenetic and drug interaction aspects on ketamine safety in its use as antidepressant ‐ implications for precision dosing in a global perspective2022 British Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Immaculate Mbongo Langmia, Katja Susanne Just, Sabrina Yamoune, Julian Peter Müller, Julia Stingl
40citations -
Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety2025 Nature Reviews Drug Discovery review Computer Science Computational Drug Discovery Methods Open access
Christopher E. Goldring, Giusy Russomanno, Carmen Pin, Panuwat Trairatphisan, Kylie A. Beattie, Ciaran P. Fisher, +36 more
19citations -
Maximizing Treatment Opportunities: Assessing Protocol Waivers’ Impact on Safety and Outcome in the Drug Rediscovery Protocol2024 Clinical Cancer Research article Mathematics Statistical Methods in Clinical Trials Open access
Jade M. van Berge Henegouwen, Laurien Joanna Zeverijn, Birgit S. Geurts, Louisa Rose Hoes, Hanneke van der Wijngaart, Vincent van der Noort, +7 more
2citations -
Influence of metabolic profiles on the safety of drug therapy in routine care in Germany: protocol of the cohort study EMPAR2020 BMJ Open article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Tatjana Huebner, Michael Steffens, Roland Linder, Jochen Fracowiak, Daria Langner, Marco Garling, +5 more
2citations -
Efficacy and safety of olaparib in patients with tumors harboring alterations in homologous recombination repair pathway associated genes: Results from the Drug Rediscovery Protocol.2024 Journal of Clinical Oncology conference-abstract Medicine PARP inhibition in cancer therapy Open access
Ilse A.C. Spiekman, Niven Mehra, Laurien Joanna Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, +10 more
3citations -
Safety and Efficacy of Upadacitinib in Patients With Active Ankylosing Spondylitis and an Inadequate Response to Nonsteroidal Antiinflammatory Drug Therapy: One‐Year Results of a Double‐Blind, Placebo‐Controlled Study and Open‐Label Extension
Atul A. Deodhar, Désirée M F M van der Heijde, Joachim Sieper, Filip E Van den Bosch, Walter P. Maksymowych, Tae‐Hwan Kim, +6 more
66citations -
Efficacy and safety of panitumumab in patients with RAF/RAS-wild-type glioblastoma: results from the drug rediscovery protocol2023 Leiden Repository (Leiden University) article Medicine Glioma Diagnosis and Treatment Open access
I.A.C. Spiekman, B.S. Geurts, L.J. Zeverijn, G.F. de Wit, V. van der Noort, P. Roepman, +12 more
0citations