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Keep looking at the negative side: improved detection of drug-induced liver injury with non-hepatotoxicant data oversampling2025 ChemRxiv preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Olivier J. M. Béquignon, Steven Wink, Steven W. Hiemstra, J. E. Fokkelman-Klip, Wouter den Hollander, Giulia Callegaro, +2 more
0citations -
Keep looking at the negative side: improved detection of drug-induced liver injury with non-hepatotoxicant data oversampling2025 ChemRxiv preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Olivier J. M. Béquignon, Steven Wink, Steven W. Hiemstra, J. E. Fokkelman-Klip, Wouter den Hollander, Giulia Callegaro, +2 more
0citations -
Transcriptomic mapping of the inter-individual variability of cellular stress response activation in primary human hepatocytes2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Marije Niemeijer, Witold Więcek, Suzanna Huppelschoten, Peter Bouwman, Audrey Baze, Celine Parmentier, +4 more
3citations -
A missense variant effect map for the human tumour suppressor protein CHK22024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Marinella Gebbia, Daniel Zimmerman, Rosanna Jiang, Jochen Weile, Roujia Li, Michelle Gavac, +9 more
1citations -
Validation of the Incremental Prognostic Value of Deceased Donation Pre-implantation Kidney Transplant Biopsies through Comprehensive Lesion Quantification with Deep Learning
Ziyang Li, Giorgio Buzzanca, Danny van der Helm, Soufian Meziyerh, Ian P.J. Alwayn, Dorottya K. de Vries, +3 more
0citations -
A simplified co-culture reveals altered cardiotoxic responses to doxorubicin in hPSC-derived cardiomyocytes in the presence of endothelial cells2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Chemotherapy-induced cardiotoxicity and mitigation Open access
Marcella Brescia, Andrea Chatrian, Paul Keselman, James Gallant, Elsa Sorman Paulsson, Mervyn P.H. Mol, +10 more
1citations -
Validation of an MPS based intestinal cell culture model for the evaluation of drug-induced toxicity2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Engineering 3D Printing in Biomedical Research Open access
Stefanie Hoffmann, Philip Hewitt, Isabel Koscielski, Dorota Kurek, Wouter Strijker, Kinga Kosim
0citations -
Ecology of prophage-like elements in Bacillus subtilis at global and local geographical scale2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Environmental Science Bacteriophages and microbial interactions Open access
Polonca Štefanič, Eva Stare, Valentina A. Floccari, Jasna Kovač, Robert Hertel, Ulisses Nunes da Rocha, +4 more
1citations -
Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse models2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access
Laura G.M. Heezen, Tamim Abdelaal, Maaike van Putten, Annemieke M Aartsma-Rus, Ahmed Essam Mahfouz, Pietro Spitali
5citations -
RecA-NT homology motif in ImuB is essential for mycobacterial ImuA’-ImuB protein interaction and mutasome function2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Joana A. Santos, Kęstutis Timinskas, Meindert Hugo Lamers, Česlovas Venclovas, Digby Francis Warner, Sophia J. Gessner
3citations -
Hybrid Reinforcement Learning and Model Predictive Control for Adaptive Control of Hydrogen-Diesel Dual-Fuel Combustion2025 arXiv (Cornell University) preprint Engineering Advanced Control Systems Optimization Open access
Julian Bedei, Alexander Winkler, Murray McBain, Charles Robert Koch, David C. Gordon
2citations -
The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Ananth Pallaseni, Elin Madli Peets, Gareth Girling, Ivan Kuzmin, Marilin Moor, Núria Muñoz-Subirana, +7 more
1citations