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Successful pharmacological intervention at different levels of the complement system in an in vitro complement fixation model for bullous pemphigoid
Jenny Giang, Martijn B. A. van Doorn, Gilles F.H. Diercks, Santiago Rodrı́guez de Córdoba, Thierry P. P. van den Bosch, Marco W.J. Schreurs, +2 more
3citations -
44 Bi-specific antibodies targeting C1q and a tumor antigen activate the complement system independent of C1q-Fc interactions2023 Immunobiology article Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors
Els van der Meijden, Frank J M Beurskens, Leendert Adrianus Trouw
0citations -
The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP222023 Current Research in Neurobiology article Neuroscience Hereditary Neurological Disorders Open access
Iliana Michailidou, Jeroen P. Vreijling, Matthijs Rumpf, Maarten Loos, Bastijn Koopmans, Nina Vlek, +6 more
8citations -
Elevated Plasma Complement Factors in CRB1 -associated Inherited Retinal Dystrophies2023 medRxiv preprint Biochemistry, Genetics and Molecular Biology Retinal Development and Disorders Open access
Lude Moekotte, Joke H. de Boer, Sanne Hiddingh, Aafke de Ligt, Xuan‐Thanh‐An Nguyen, Carel B. Hoyng, +27 more
0citations -
Systemic and local complement activation in peritoneal dialysis patients via conceivably distinct pathways2023 Peritoneal Dialysis International article Immunology and Microbiology Complement system in diseases Open access
Bernardo Faria, Mariana Gaya da Costa, Stefan P. Berger, Carla Lima, Cátia Pêgo, Jacob van den Born, +5 more
1citations -
DNA nanostructure-templated antibody complexes provide insights into the geometric requirements of human complement cascade activation2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Complement system in diseases Open access
Leoni Abendstein, Willem E. M. Noteborn, Luc S. Veenman, Douwe J. Dijkstra, Fleur S. van de Bovenkamp, Leendert Adrianus Trouw, +1 more
0citations -
Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids2023 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access
Lonneke H. Gaykema, Rianne Y. van Nieuwland, Mette C. Dekkers, Mieke F. van Essen, Sebastiaan Heidt, Arnaud Zaldumbide, +3 more
17citations -
Complement activation drives antibody-mediated transfusion-related acute lung injury via macrophage trafficking and formation of NETs2023 Blood article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent
Saskia van der Velden, Thijs L. J. van Osch, Amina Seghier, Arthur E. H. Bentlage, Juk Yee Mok, Dionne M. Geerdes, +9 more
51citations -
POSTER: MDS-278 Substantial Increases in Paroxysmal Nocturnal Hemoglobinuria (PNH) Red Blood Cell Clone Size With Oral Iptacopan Monotherapy Confirms Control of Hemolysis in Complement Inhibitor-Naive PNH Patients2023 Clinical Lymphoma Myeloma & Leukemia article Immunology and Microbiology Complement system in diseases Open access
Régis Peffault de Latour, Bing Han, Jaroslaw Pawel Maciejewski, Yasutaka Ueda, Rong Fu, Li Zhang, +15 more
0citations -
Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains2023 Nature Communications article Immunology and Microbiology Complement system in diseases Open access cited by 2 patents
Leoni Abendstein, Douwe J. Dijkstra, Rayman T.N. Tjokrodirijo, Peter A. van Veelen, Leendert Adrianus Trouw, Paul J. Hensbergen, +1 more
50citations -
S183: PHASE III RANDOMIZED, MULTICENTER, OPEN-LABEL COMMODORE 1 TRIAL: COMPARISON OF CROVALIMAB VS ECULIZUMAB IN COMPLEMENT INHIBITOR-EXPERIENCED PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
Phillip Scheinberg, Diego V. Clé, Valentina Giai, Marek Hus, Jin Seok Kim, Cristina Barrenetxea Lekue, +11 more
5citations -
P774: SUBSTANTIAL INCREASES IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) RED BLOOD CELL CLONE SIZE WITH ORAL IPTACOPAN MONOTHERAPY CONFIRMS CONTROL OF HEMOLYSIS IN COMPLEMENT INHIBITOR-NAÏVE PNH PATIENTS
Régis Peffault de Latour, Bing Han, Jaroslaw Pawel Maciejewski, Yutaka Ueda, Rong Fu, Li Zhang, +15 more
3citations -
MDS-278 Substantial Increases in Paroxysmal Nocturnal Hemoglobinuria (PNH) Red Blood Cell Clone Size With Oral Iptacopan Monotherapy Confirms Control of Hemolysis in Complement Inhibitor-Naive PNH Patients2023 Clinical Lymphoma Myeloma & Leukemia conference-abstract Immunology and Microbiology Complement system in diseases Open access
Régis Peffault de Latour, Bing Han, Jaroslaw Pawel Maciejewski, Yasutaka Ueda, Rong Fu, Li Zhang, +15 more
1citations