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Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators2024 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access
Haiyu Wang, Fleur S. van de Bovenkamp, Douwe J. Dijkstra, Leoni Abendstein, Nicole V. Borggreven, Jos Pool, +10 more
11citations -
Development of bispecific antibodies that drive selective targeted local complement inhibition on rheumatoid arthritis-related antigens2025 Annals of the Rheumatic Diseases article Immunology and Microbiology Complement system in diseases Open access
Haiyu Wang, Rick J. Groenland, Stef van der Meulen, Hanneke Kapsenberg, Christoph Gstöttner, Elena Domínguez‐Vega, +5 more
10citations -
99 Targeted complement inhibition using engineered bispecific antibodies that bind local antigens and endogenous complement regulators as a novel therapeutic approach2023 Immunobiology article Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors
Leendert Adrianus Trouw, Leoni Abendstein, Kyra A. Gelderman, Paul W.H.I. Parren, Thomas Harry Sharp, Fleur S. van de Bovenkamp
0citations -
Tackling Neuroinflammation After Traumatic Brain Injury: Complement Inhibition as a Therapy for Secondary Injury2022 Neurotherapeutics article Medicine Traumatic Brain Injury and Neurovascular Disturbances Open access
Inge A. M. van Erp, Iliana Michailidou, Thomas Arjan van Essen, Mathieu van der Jagt, Wouter A. Moojen, Wilco C. Peul, +2 more
67citations -
#3018 Iptacopan's rapid and sustained inhibition of overactive complement alternative pathway in C3G: Exploratory analysis from the Phase 3 APPEAR-C3G study2025 Nephrology Dialysis Transplantation article Immunology and Microbiology Complement system in diseases Open access
Erica Daina, Giuseppe Remuzzi, David Kavanagh, Imelda Schuhmann, Rubeen Israni, Hari Varun Kalluri, +4 more
0citations -
Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids2023 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access
Lonneke H. Gaykema, Rianne Y. van Nieuwland, Mette C. Dekkers, Mieke F. van Essen, Sebastiaan Heidt, Arnaud Zaldumbide, +3 more
17citations -
Expert guidance on when to screen, monitor, and initiate complement inhibition therapy in patients without classical PNH2026 Blood Red Cells & Iron article Immunology and Microbiology Complement system in diseases Open access
Vinod A. Pullarkat, Daria V. Babushok, Carlos M. de Castro, David Dingli, Jamie Lynn Koprivnikar, Jaroslaw Pawel Maciejewski, +8 more
0citations -
Oral Monotherapy with Iptacopan, a Proximal Complement Inhibitor of Factor B, Has Superior Efficacy to Intravenous Terminal Complement Inhibition with Standard of Care Eculizumab or Ravulizumab and Favorable Safety in Patients with Paroxysmal Nocturnal Hemoglobinuria and Residual Anemia: Results from the Randomized, Active-Comparator-Controlled, Open-Label, Multicenter, Phase III Apply-PNH Study
Régis Peffault de Latour, Alexander Roeth, Austin Gladston Kulasekararaj, Phillip Scheinberg, Yasutaka Ueda, Carlos M. de Castro, +15 more
23citations -
Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP2025 Molecular & Cellular Proteomics article Immunology and Microbiology Complement system in diseases Open access
Tereza Kadavá, Jürgen Strasser, Maryam Marefat, Victor C. Yin, Johannes Preiner, Leendert Adrianus Trouw, +1 more
5citations -
Inhibition of complement factor C5a or C5aR for cholesterol crystal embolism–related vascular thrombosis with microvascular injury and its consequences2024 Kidney International article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent
Chao Han, Elmina Mammadova‐Bach, Kanako Watanabe‐Kusunoki, Tâmisa Seeko Bandeira Honda, Yihong Li, Chenyu Li, +16 more
13citations -
The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP222023 Current Research in Neurobiology article Neuroscience Hereditary Neurological Disorders Open access
Iliana Michailidou, Jeroen P. Vreijling, Matthijs Rumpf, Maarten Loos, Bastijn Koopmans, Nina Vlek, +6 more
8citations -
Combined inhibition of the complement component C5 and the TLR-coreceptor CD14 alters the posttraumatic response in fracture hematoma in a porcine polytrauma model2025 Innovative Surgical Sciences article Immunology and Microbiology Immune Response and Inflammation Open access
Klemens Horst, Ümit Mert, Johannes Greven, Felix Bläsius, Tom Eirik Mollnes, Markus Stefan Huber-Lang, +3 more
0citations -
Reply to the correspondence on ‘Development of bispecific antibodies that allow targeted local complement inhibition on rheumatoid arthritis related antigens’2026 Annals of the Rheumatic Diseases letter Immunology and Microbiology Complement system in diseases
Haiyu Wang, Saskia Nugteren, Rick J. Groenland, Stef van der Meulen, Hanneke Kapsenberg, Christoph Gstöttner, +5 more
0citations -
Complement activation in secondary thrombotic microangiopathies2025 Nephrology Dialysis Transplantation article Immunology and Microbiology Complement system in diseases Open access
Johann Morelle, Fernando Caravaca‐Fontán, Fádi Fakhouri, Eleni A. Frangou, Annette N. Bruchfeld, Jürgen Floege, +9 more
18citations -
COMPOSER Part 4: An Optimized Dosing Strategy for Crovalimab in the Treatment of Complement Inhibitor-Naïve or -Experienced Patients with Paroxysmal Nocturnal Hemoglobinuria
Régis Peffault de Latour, Simona Sica, Julia G. Ramos, Jules Hernández‐Sánchez, Jin Seok Kim, Anna Kiialainen, +11 more
3citations -
Combined C5 and CD14 inhibition balances immunological miRNA responses after multiple trauma in pigs2025 DataverseNL dataset Immunology and Microbiology Inflammation biomarkers and pathways Open access
Rald Groven, Ümit Mert, Johannes Greven, Zhizhen He, Nan Zhou, Martijn Poeze, +5 more
0citations -
Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys2022 Frontiers in Immunology article Medicine Organ Transplantation Techniques and Outcomes Open access
Neeltina M. Jager, Leonie H. Venema, Asel S. Arykbaeva, Anita H. Meter-Arkema, Petra J. Ottens, Cees van Kooten, +4 more
23citations