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Enhancing complement activation by therapeutic anti-tumor antibodies: Mechanisms, strategies, and engineering approaches2024 Seminars in Immunology article Immunology and Microbiology Complement system in diseases Open access
Vitalijs Ovcinnikovs, Karin Dijkman, Gijs G. Zom, Frank J M Beurskens, Leendert Adrianus Trouw
18citations -
DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation2024 Journal of the American Chemical Society article Immunology and Microbiology Complement system in diseases Open access cited by 2 patents
Leoni Abendstein, Willem E. M. Noteborn, Luc S. Veenman, Douwe J. Dijkstra, Fleur S. van de Bovenkamp, Leendert Adrianus Trouw, +1 more
16citations -
Thrombospondin-1 inhibits alternative complement pathway activation in vasculitis synergistically to factor H2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Complement system in diseases Open access
Swagata Konwar, Sophie Schroda, Jessika Kleindienst, Eva L. Decker, Martin Pohl, Barbara Zieger, +10 more
0citations -
Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Biomarkers in Disease Mechanisms Open access cited by 2 patents
Dylan P. Noone, Marjolein M. E. Isendoorn, Sebastiaan M. W. R. Hamers, Mariska E. Keizer, Jip Wulffelé, Tijn T. van der Velden, +4 more
3citations -
Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein2024 Proceedings of the National Academy of Sciences article Immunology and Microbiology Biomarkers in Disease Mechanisms Open access cited by 2 patents
Dylan P. Noone, Marjolein M. E. Isendoorn, Sebastiaan M. W. R. Hamers, Mariska E. Keizer, Jip Wulffelé, Tijn T. van der Velden, +4 more
26citations -
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation2024 The Journal of Immunology article Immunology and Microbiology Complement system in diseases Open access
Sebastiaan M. W. R. Hamers, Aimee L. Boyle, Thomas Harry Sharp
5citations -
Apical tubular complement activation and the loss of kidney function in proteinuric kidney diseases2024 Clinical Kidney Journal article Immunology and Microbiology Complement system in diseases Open access
Firas Farisi Alkaff, Rosa G. M. Lammerts, Mohamed R. Daha, Stefan P. Berger, Jacob van den Born
12citations -
Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators2024 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent
Haiyu Wang, Fleur S. van de Bovenkamp, Douwe J. Dijkstra, Leoni Abendstein, Nicole V. Borggreven, Jos Pool, +10 more
11citations -
Circulating levels of endogenous complement inhibitors correlate inversely with complement consumption in systemic lupus erythematosus2024 European Journal of Immunology article Medicine Systemic Lupus Erythematosus Research Open access
Stef van der Meulen, Rory Caitlin Monahan, Kyra A. Gelderman, Cees van Kooten, Y K Onno Teng, Tom W. J. Huizinga, +2 more
3citations -
Inhibition of complement factor C5a or C5aR for cholesterol crystal embolism–related vascular thrombosis with microvascular injury and its consequences2024 Kidney International article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent
Chao Han, Elmina Mammadova‐Bach, Kanako Watanabe‐Kusunoki, Tâmisa Seeko Bandeira Honda, Yihong Li, Chenyu Li, +16 more
13citations -
Phase 3 randomized COMMODORE 1 trial: Crovalimab versus eculizumab in complement inhibitor‐experienced patients with paroxysmal nocturnal hemoglobinuria2024 American Journal of Hematology article Immunology and Microbiology Complement system in diseases Open access
Phillip Scheinberg, Diego V. Clé, Jin Seok Kim, Erfan Nur, Mustafa Nuri Yenerel, Wilma Barcellini, +15 more
52citations -
Selection and characterization of a peptide-based complement modulator targeting C1 of the innate immune system2024 RSC Chemical Biology article Immunology and Microbiology Complement system in diseases Open access
Sebastiaan M. W. R. Hamers, Leoni Abendstein, Aimee L. Boyle, Seino A. K. Jongkees, Thomas Harry Sharp
2citations -
Monotherapy Treatment with Zaltenibart (OMS906), an Alternative Pathway Masp-3 Inhibitor, Improved Key Hematologic Parameters in Patients with PNH with a Suboptimal Response to Ravulizumab: Interim Results from a Phase 2 Proof-of-Concept Study
Morag Griffin, Richard J. Kelly, Mathilde Gavillet, Petra Muus, Britta Hoechsmann, W. Jason Cummings, +4 more
4citations -
Danicopan As Add-on Therapy to Ravulizumab or Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria: Long-Term Patient-Reported Outcomes from the Phase 3 ALPHA Trial2024 Blood conference-abstract Immunology and Microbiology Complement system in diseases Open access
Caroline Irene Piatek, Jong Wook Lee, Morag Griffin, J Nishimura, Christopher Jordan Patriquin, Hubert Schrezenmeier, +9 more
2citations -
Plain language summary: treatment of paroxysmal nocturnal hemoglobinuria with pegcetacoplan for 48 weeks (PEGASUS study)2024 Future Rare Diseases article Immunology and Microbiology Complement system in diseases Open access
Régis Peffault de Latour, Jeff Szer, Ilene Ceil Weitz, Alexander Röth, Britta Höchsmann, Jens Panse, +10 more
0citations