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Methods for Prioritizing Causal Genes in Molecular Studies of Human Disease: The State of the Art2026 Genetic Epidemiology article Biochemistry, Genetics and Molecular Biology Genetic Associations and Epidemiology Open access
Karina Patasova, Bahareh Sedaghati-khayat, Rachel Knevel, Heather Jane Cordell, Arthur G. Pratt
1citations -
A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury2023 Toxicological Sciences article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Lukas S. Wijaya, Attila Gábor, Iris Pot, Luca van de Have, Julio Sáez-Rodríguez, James L. Stevens, +3 more
13citations -
Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids2020 Nature Communications article Biochemistry, Genetics and Molecular Biology Genetic Associations and Epidemiology Open access
Adriaan van der Graaf, Annique Claringbould, Antoine Rimbert, Bastiaan T. Heijmans, Peter A.C. ’t Hoen, Joyce B. J. van Meurs, +6 more
61citations -
Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference2020 Genome biology article Biochemistry, Genetics and Molecular Biology Epigenetics and DNA Methylation Open access cited by 1 patent
Paul J. Hop, René Luijk, Lucia Daxinger, Maarten van Iterson, Koen F. Dekkers, Rick Jansen, +40 more
41citations -
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes2020 Nature Genetics article Biochemistry, Genetics and Molecular Biology Genetic Associations and Epidemiology Open access
Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R. Barnes, Jamie Allen, Siddhartha Kar, +88 more
190citations -
DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease2025 Diabetologia article Biochemistry, Genetics and Molecular Biology Epigenetics and DNA Methylation Open access
Lucy Sinke, Thomas Delerue, Rory Wilson, Xueling Lu, Yujing Xia, Ricardo Costeira, +19 more
7citations -
Direct evaluation of neuroaxonal degeneration with the causative genes of neurodegenerative diseases in Drosophila using the automated axon quantification system, MeDUsA2023 Human Molecular Genetics article Biochemistry, Genetics and Molecular Biology Cell Image Analysis Techniques Open access
Yohei Nitta, Hiroki Kawai, Ryuto Maki, Jiro Osaka, Satoko Hakeda‐Suzuki, Yoshitaka Nagai, +7 more
17citations -
Proton Pump Inhibitors Modulate Gene Expression Profile in Esophageal Mucosa and Microbiome2023 The Journal of Pediatric Pharmacology and Therapeutics article Medicine Gastroesophageal reflux and treatments Open access
Seesandra V. Rajagopala, Meghan H. Shilts, Hernán Correa, Suman R. Das, Yash A. Choksi, Justin Jacobse, +2 more
5citations -
Genetic correlation, and causal relationships between 3 solid cancer types and human traits2024 Network Modeling Analysis in Health Informatics and Bioinformatics article Biochemistry, Genetics and Molecular Biology Genetic Associations and Epidemiology
Claudia Cava, Ehsan Nazemalhosseini Mojarad, Isabella Castiglioni
1citations -
Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome2022 The American Journal of Human Genetics article Biochemistry, Genetics and Molecular Biology Genetics and Neurodevelopmental Disorders Open access
Federico Tessadori, Karen J. Duran, Matthias Fellner, Sarah Smithson, Ana Beleza‐Meireles, Mariet W. Elting, +57 more
36citations -
Contextualization of causal regulatory networks from toxicogenomics data applied to drug-induced liver injury2021 Toxicology Letters article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Panuwat Trairatphisan, Terezinha Maria de Souza, Jos C. S. Kleinjans, Danyel G. J. Jennen, Julio Sáez-Rodríguez
4citations -
The Minimum Information about a Molecular Interaction CAusal STatement (MI2CAST)2020 Bioinformatics article Biochemistry, Genetics and Molecular Biology Bioinformatics and Genomic Networks Open access
Vasundra Touré, Steven Vercruysse, Márcio Luís Acencio, Ruth C. Lovering, Sandra E. Orchard, Glyn Bradley, +20 more
23citations -
Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses2021 Molecular Systems Biology article Biochemistry, Genetics and Molecular Biology Bioinformatics and Genomic Networks Open access
Aurélien J. F. Dugourd, Christoph Kuppe, Marco Sciacovelli, Enio Gjerga, Attila Gábor, Kristina Bennet Emdal, +12 more
156citations -
Gene deletion and constitutive expression of the pectate lyase gene 1 (MoPL1) lead to diminished virulence of Magnaporthe oryzae2021 The Journal of Microbiology article Biochemistry, Genetics and Molecular Biology Plant Pathogens and Fungal Diseases
Alex Wegner, Florencia Casanova, Marco Loehrer, Angelina Jordine, Stefan Bohnert, Xinyu Liu, +2 more
23citations -
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification2023 Nature Genetics article Biochemistry, Genetics and Molecular Biology Genetic Associations and Epidemiology Open access
Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian Lacks Lino Cardenas, Doris Wong, Haojie Lu, +83 more
123citations -
Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study2023 Diabetologia article Biochemistry, Genetics and Molecular Biology Genetic Associations and Epidemiology Open access
Juliette A. de Klerk, Joline W. J. Beulens, Hailiang Mei, Roel Bijkerk, Anton Jan van Zonneveld, Robert Wilhelm Koivula, +3 more
39citations -
Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study
Richard A. J. Howey, Jonathan Adam, Jerzy Adamski, Natalie N. Atabaki, Søren Brunak, Piotr Jaroslaw Chmura, +32 more
1citations -
Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients2024 Frontiers in Immunology article Immunology and Microbiology Atherosclerosis and Cardiovascular Diseases Open access
Chang Wei Lu, Marjo M. P. C. Donners, Julius B. J. de Baaij, Han Young Jin, Jeroen J. T. Otten, Marco Manca, +11 more
2citations -
Chromosome 10q-linked FSHD identifies DUX4 as principal disease gene2021 Journal of Medical Genetics article Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access cited by 7 patents
Richard J.L.F. Lemmers, Patrick J. van der Vliet, Ana Blatnik, Judit Balog, Janez Zidar, Don Henderson, +7 more
44citations -
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis2022 Genome biology article Biochemistry, Genetics and Molecular Biology Genetic Associations and Epidemiology Open access
Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida L. Surakka, Shweta Ramdas, Xiang Zhu, +93 more
61citations