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Structure-activity relationship of S-adenosylmethionine analogs as pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria2025 International Journal of Biological Macromolecules article Medicine Folate and B Vitamins Research Open access
Thilo Magnus Philipp, Ela Mijatović, Maria Petrosino, Kelly Ascenção, Teodoro Bottiglieri, Elmar G. Weinhold, +3 more
1citations -
Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase2023 International Journal of Biological Macromolecules article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access
Jing Sun, Aleksandra Chikunova, Aimee L. Boyle, Patrick Voskamp, Monika Timmer, Marcellus Ubbink
13citations -
Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases
Daniël van der Gracht, Rhianna J. Rowland, V. Roig-Zamboni, Maria J. Ferraz, Max Louwerse, Paul P. Geurink, +5 more
12citations -
Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities2020 Journal of Lipid Research article Biochemistry, Genetics and Molecular Biology Genetic and rare skin diseases. Open access cited by 1 patent
Jeroen van Smeden, Hanin Al-Khakany, Yichen Wang, Dani Visscher, Samira Absalah, Herman S. Overkleeft, +3 more
29citations -
Sympathetic and Vagal Nerve Activity in COPD: Pathophysiology, Presumed Determinants and Underappreciated Therapeutic Potential2022 Frontiers in Physiology article Medicine Chronic Obstructive Pulmonary Disease (COPD) Research Open access
Jens Spießhoefer, Binaya Regmi, Matteo Maria Ottaviani, Florian Kahles, Alberto Giannoni, Chiara Borrelli, +3 more
30citations -
Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition2020 Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids article Medicine Dermatology and Skin Diseases Open access
Daphne E.C. Boer, Jeroen van Smeden, Hanin Al-Khakany, Elizaveta V. Melnik, Rianne van Dijk, Samira Absalah, +6 more
41citations -
SAAP-148 and halicin exhibit synergistic antimicrobial activity against antimicrobial-resistant bacteria in skin but not airway epithelial culture models2025 JAC-Antimicrobial Resistance article Immunology and Microbiology Antimicrobial Peptides and Activities Open access
Patrick R. Lennard, Pieter Sicco Hiemstra, Julia R. Dorin, Peter H. Nibbering
1citations -
Phosphate ions modulate enzyme activity and epistatic effects in two clavulanic acid‐resistant β‐lactamase mutants2025 Protein Science article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access
Marko Radojković, Saar F. Koene, Aleksandra Chikunova, Bogdan I. Florea, Sivanandam V. Natarajan, Aimee L. Boyle, +1 more
3citations -
HEPES‐buffering of bicarbonate‐containing culture medium perturbs lysosomal glucocerebrosidase activity2022 Journal of Cellular Biochemistry article Medicine Lysosomal Storage Disorders Research Open access
Martijn J. C. van der Lienden, Jan Aten, Rolf G. Boot, Marco van Eijk, Johannes M. F. G. Aerts, C.J. Kuo
6citations -
Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis2023 Signal Transduction and Targeted Therapy article Biochemistry, Genetics and Molecular Biology Extracellular vesicles in disease Open access
Adilson Fonseca Teixeira, Yanhong Wang, Josephine Iaria, Peter ten Dijke, Hong‐Jian Zhu
26citations -
Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity2025 Materials Today Bio article Biochemistry, Genetics and Molecular Biology TGF-β signaling in diseases Open access
Chen‐Yi Liao, Jasmijn H.M. Hundscheid, Justin Crawford, Peter ten Dijke, Beatrice Coornaert, Erik H.J. Danen
2citations -
Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate2022 Gut Microbes article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Joshua B. Simpson, Josh J. Sekela, Amanda L. Graboski, Valentina Borlandelli, Marissa M. Bivins, Natalie K. Barker, +9 more
43citations -
Interstitial flow potentiates TGF-β/Smad-signaling activity in lung cancer spheroids in a 3D-microfluidic chip2023 Lab on a Chip article Biochemistry, Genetics and Molecular Biology TGF-β signaling in diseases Open access
Zaid Rahman, Ankur Bordoloi, Haifa Rouhana, Margherita Tavasso, Gerard van der Zon, Valeria Garbin, +2 more
18citations -
Grubbs-Hoveyda catalysts conjugated to a β-barrel protein: Effect of halide substitution on aqueous olefin metathesis activity2024 Journal of Inorganic Biochemistry article Chemistry Synthetic Organic Chemistry Methods Open access
Aaron A. Ingram, Dong Hua Wang, Ulrich Schwaneberg, Jun Okuda
10citations -
CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors2024 Cellular and Molecular Immunology article Immunology and Microbiology Immunotherapy and Immune Responses Open access
Xin Lei, Daniël de Groot, Marij J.P. Welters, Tom de Wit, Ellen Schrama, Hans van Eenennaam, +10 more
65citations -
R-Propranolol Has Broad-Spectrum Anti-Coronavirus Activity and Suppresses Factors Involved in Pathogenic Angiogenesis2023 International Journal of Molecular Sciences article Medicine SARS-CoV-2 and COVID-19 Research Open access
Melissa Thaler, Clarisse Salgado‐Benvindo, Anouk A. Leijs, Ali Taş, Dennis K. Ninaber, Jack L. Arbiser, +2 more
9citations -
Extracellular Vesicles from M1-Polarized Macrophages Combined with Hyaluronic Acid and a β-Blocker Potentiate Doxorubicin’s Antitumor Activity by Downregulating Tumor-Associated Macrophages in Breast Cancer2022 Pharmaceutics article Biochemistry, Genetics and Molecular Biology Extracellular vesicles in disease Open access
Carla Jorquera‐Cordero, Pablo Lara, Luis Javier Cruz, Timo Schomann, Anna van Hofslot, Thaís Gomes de Carvalho, +5 more
28citations