Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases

Chemical Science, vol. 14, pp. 9136–9144

Abstract

-alkyldeoxynojirimycins that inhibit GAA, but not GBA1, and that may form the starting point for the development of pharmacological chaperone therapeutics for the lysosomal glycogen storage disease that results from genetic deficiency in GAA: Pompe disease.

Authors 11

1. Daniël van der Gracht Aachen

   Leiden University

   Affiliation as printed

   Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

   Universiteit Leiden = Leiden University (Leiden University | 2300 RA Leiden The Netherlands - Netherlands)

2. Rhianna J. Rowland

   University of York

   Affiliation as printed

   York Structural Biology Laboratory, Department of Chemistry, The University of York, York YO10 5DD, UK

3. V. Roig-Zamboni

   Centre National de la Recherche Scientifique · Aix-Marseille Université · Architecture et Fonction des Macromolécules Biologiques

   Affiliation as printed

   Architecture et Fonction des Macromolécules Biologiques (AFMB), CNRS, Aix-Marseille University, Marseille, France

4. Maria J. Ferraz Aachen

   Leiden University

   Affiliation as printed

   Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

   Universiteit Leiden = Leiden University (Leiden University | 2300 RA Leiden The Netherlands - Netherlands)

5. Max Louwerse Aachen

   Leiden University

   Affiliation as printed

   Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

   Universiteit Leiden = Leiden University (Leiden University | 2300 RA Leiden The Netherlands - Netherlands)

6. Paul P. Geurink Aachen Department of Cell and Chemical Biology

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Cell and Chemical Biology, Leiden University Medical Centre, 2333 ZC Leiden, The Netherlands

   Universiteit Leiden = Leiden University (Leiden University | 2300 RA Leiden The Netherlands - Netherlands)

7. Johannes M. F. G. Aerts Aachen

   Leiden University

   Affiliation as printed

   Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

   Universiteit Leiden = Leiden University (Leiden University | 2300 RA Leiden The Netherlands - Netherlands)

8. Gerlind Sulzenbacher

   Centre National de la Recherche Scientifique · Aix-Marseille Université · Architecture et Fonction des Macromolécules Biologiques

   Affiliation as printed

   Architecture et Fonction des Macromolécules Biologiques (AFMB), CNRS, Aix-Marseille University, Marseille, France

9. G.J. Davies

   University of York

   Affiliation as printed

   York Structural Biology Laboratory, Department of Chemistry, The University of York, York YO10 5DD, UK

10. Herman S. Overkleeft Aachen

    Leiden University

    Affiliation as printed

    Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

    Universiteit Leiden = Leiden University (Leiden University | 2300 RA Leiden The Netherlands - Netherlands)

11. Marta Artola Aachen

    Leiden University

    Affiliation as printed

    Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

    Universiteit Leiden = Leiden University (Leiden University | 2300 RA Leiden The Netherlands - Netherlands)