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Safety and tumour-specific immunological responses of combined dendritic cell vaccination and anti-CD40 agonistic antibody treatment for patients with metastatic pancreatic cancer: protocol for a phase I, open-label, single-arm, dose-escalation study (REACtiVe-2 trial)
Sai Ping Lau, Freek R. van ‘t Land, Sjoerd H. van der Burg, Marjolein Y.V. Homs, Martijn P. Lolkema, Joachim G.J.V. Aerts, +1 more
9citations -
Dual site-specific chemoenzymatic antibody fragment conjugation using CRISPR-based hybridoma engineering2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Monoclonal and Polyclonal Antibodies Research Open access
Camille M. Le Gall, Johan M. S. van der Schoot, Iván Ramos‐Tomillero, Melek Parlak Khalily, Floris J. van Dalen, Zacharias Wijfjes, +7 more
1citations -
Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents2022 Journal of Nanobiotechnology article Medicine Radiopharmaceutical Chemistry and Applications Open access
Iris M. Hagemans, Peter J. Wierstra, Kas Steuten, Janneke D.M. Molkenboer‐Kuenen, Duco van Dalen, Martin ter Beest, +7 more
10citations -
Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe2024 ACS Chemical Biology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Lisa S. den Hollander, Bert L. H. Beerkens, Sebastian Dekkers, Jacobus P. D. van Veldhoven, Natalia V. Ortiz Zacarı́as, Cas van der Horst, +6 more
2citations -
Endopeptidase Cleavage of Anti-Glomerular Basement Membrane Antibodies in vivo in Severe Kidney Disease: An Open-Label Phase 2a Study2022 Journal of the American Society of Nephrology article Medicine Vasculitis and related conditions Open access cited by 2 patents
Fredrik Uhlin, Wladimir M. Szpirt, Andreas Kronbichler, Annette N. Bruchfeld, Inga Soveri, Lionel P. E. Rostaing, +14 more
70citations -
Replication, safety and immunogenicity of the vectored Ebola vaccine rVSV-ΔG-ZEBOV-GP in a sub-Saharan African paediatric population: A randomised controlled, open-label trial in children aged 1-12 years living in Lambaréné, Gabon
Ayodele Kamal ALABI, Kossiwa Kokou, Saïdou Mahmoudou, Ranmali Kavishna, Sravya Sowdamini Nakka, Sylvia Rothenberger, +12 more
8citations -
Subcutaneous Daratumumab with Rapid Corticosteroid Tapering in Relapsed or Refractory Multiple Myeloma Patients: Part 3 Update of the Open-Label, Multicenter, Phase 1b Pavo Study
Hareth Nahi, Saad Z. Usmani, María‐Victoria Mateos, Niels W.C.J. van de Donk, Philippe Moreau, Albert Oriol, +8 more
2citations -
Oral Monotherapy with Iptacopan, a Proximal Complement Inhibitor of Factor B, Has Superior Efficacy to Intravenous Terminal Complement Inhibition with Standard of Care Eculizumab or Ravulizumab and Favorable Safety in Patients with Paroxysmal Nocturnal Hemoglobinuria and Residual Anemia: Results from the Randomized, Active-Comparator-Controlled, Open-Label, Multicenter, Phase III Apply-PNH Study
Régis Peffault de Latour, Alexander Roeth, Austin Gladston Kulasekararaj, Phillip Scheinberg, Yasutaka Ueda, Carlos M. de Castro, +15 more
23citations -
Isatuximab, Lenalidomide, Bortezomib and Dexamethasone Induction Therapy for Transplant-Eligible Patients with Newly Diagnosed Multiple Myeloma: Final Progression-Free Survival Analysis of Part 1 of an Open-Label, Multicenter, Randomized, Phase 3 Trial (GMMG-HD7)
Hartmut Goldschmidt, Uta Bertsch, Ema Požek, Axel Benner, Roland R. Fenk, Britta Besemer, +26 more
1citations -
Abstract No: 305 PROMINENT: AN OPEN-LABEL, RANDOMIZED PHASE 3 TRIAL OF FELZARTAMAB IN PRIMARY MEMBRANOUS NEPHROPATHY2026 Kidney International Reports conference-abstract Medicine Renal Diseases and Glomerulopathies Open access
J. Floege, Pierre Marie Ronco, A. Liew, H. Reich, V. Jha, W. Yang, +6 more
0citations -
Dual Site-Specific Chemoenzymatic Antibody Fragment Conjugation Using CRISPR-Based Hybridoma Engineering2021 Bioconjugate Chemistry article Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 2 patents
Camille M. Le Gall, Johan M. S. van der Schoot, Iván Ramos‐Tomillero, Melek Parlak Khalily, Floris J. van Dalen, Zacharias Wijfjes, +7 more
26citations -
Radiolabeled Monoclonal Antibody Against Colony-Stimulating Factor 1 Receptor Specifically Distributes to the Spleen and Liver in Immunocompetent Mice2021 Frontiers in Oncology article Medicine Radiopharmaceutical Chemistry and Applications Open access
Stijn J.H. Waaijer, Frans V. Suurs, Cheei‐Sing Hau, Kim Vrijland, Karin E. de Visser, Derk Jan A. de Groot, +3 more
9citations -
A photoaffinity glycan-labeling approach to investigate immunoglobulin glycan-binding partners2023 Glycobiology article Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access
Miles D. Holborough-Kerkvliet, Greta Mucignato, Sam J. Moons, Venetia Psomiadou, Rohit Sai Reddy Konada, Nichole J. Pedowitz, +11 more
5citations -
Side-by-Side Comparison of uPAR-Targeting Optical Imaging Antibodies and Antibody Fragments for Fluorescence-Guided Surgery of Solid Tumors2021 Molecular Imaging and Biology article Medicine Optical Imaging and Spectroscopy Techniques Open access cited by 3 patents
Victor M. Baart, Labrinus van Manen, Shadhvi S. Bhairosingh, Floris A. Vuijk, Luisa Iamele, Hugo de Jonge, +8 more
17citations -
A first-in-human study of DYP688, an antibody drug conjugate delivering a direct Gq/11 inhibitor, in patients with metastatic uveal melanoma (MUM) and other GNAQ/11 mutant melanomas.2025 Journal of Clinical Oncology conference-abstract Medicine Ocular Oncology and Treatments Open access
Matteo Salvatore Carlino, Reinhard Dummer, Tanja Gromke, Jessica Cecile Hassel, Ellen Kapiteijn, Damien Kee, +12 more
6citations -
Imaging the pharmacokinetics and therapeutic availability of the bispecific CD3xTRP1 antibody in syngeneic mouse tumor models2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Radiopharmaceutical Chemistry and Applications Open access
Gerwin W. Sandker, Jim Middelburg, Evienne Wilbrink, Janneke D.M. Molkenboer‐Kuenen, Erik H.J.G. Aarntzen, Thorbald van Hall, +1 more
2citations -
Super-Resolution Imaging of the A- and B-Type Lamin Networks: A Comparative Study of Different Fluorescence Labeling Procedures2021 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Nuclear Structure and Function Open access
Merel Stiekema, Frans C. S. Ramaekers, Dimitrios Kapsokalyvas, Marc A. M. J. van Zandvoort, Rogier J. A. Veltrop, Jos L. V. Broers
21citations -
Abstract OT1-02-01: Phase III postneoadjuvant study evaluating sacituzumab govitecan (SG), an antibody drug conjugate in primary HER2-negative breast cancer patients with high relapse risk after standard neoadjuvant treatment - SASCIA2022 Cancer Research conference-abstract Biochemistry, Genetics and Molecular Biology Breast Cancer Treatment Studies
Frederik Marmé, Marcus Schmidt, Jenny Furlanetto, Carsten Denkert, Anthony Gonçalvès, Elmar Stickeler, +15 more
0citations -
ASP2998, a trophoblast cell-surface antigen 2 (TROP2)–targeted immunostimulatory antibody-drug conjugate with dual payloads, in patients with locally advanced unresectable or metastatic solid tumors: A phase 1b/2 study.
Guru Sonpavde, Martin Gutierrez, Anumeha Gupta, Shigehiro Koganemaru, Geraldine O’Sullivan Coyne, Jeffery Scott Russell, +8 more
0citations