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Discovery and Functional Characterization of a Potent, Selective, and Metabolically Stable PROTAC of the Protein Kinases DYRK1A and DYRK1B2024 Journal of Medicinal Chemistry article Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors Open access
Gerrit Wilms, Kevin Schofield, Shayna Maddern, Christopher Foley, Yeng Shaw, Breland E. Smith, +13 more
17citations -
Reversing PROTAC-induced ASH2L degradation reactivates proliferation in senescent cells2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors Open access
Janina Müller, Mirna Barsoum, Philip Bussmann, Mohamed H. Elsafi Mabrouk, Roksaneh Sayadi-Boroujeni, Anna-Maria Vllaho, +6 more
0citations -
Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell2024 Journal of Medicinal Chemistry article Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors Open access
Yuqing Jia, Merve Oyken, Robbert Q. Kim, Rayman T.N. Tjokrodirijo, Arnoud H. de Ru, Antonius P. A. Janssen, +4 more
7citations -
Harnessing PROTAC technology to combat stress hormone receptor activation2023 Nature Communications article Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors Open access
Mahshid Gazorpak, Karina M. Hugentobler, Dominique Paul, Pierre‐Luc Germain, Miriam Kretschmer, Iryna Ivanova, +15 more
22citations -
First-in-human study to assess the safety, pharmacokinetics, and pharmacodynamics of ARV-102, a PROTAC LRRK2 degrader, in healthy volunteers2025 Parkinsonism & Related Disorders article Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors
Sergey Aksenov, Ana LC Zaninotto, Thomas Storz, Y. Folami, C. Lubeski, Marsha MacDougall, +4 more
9citations -
Harnessing PROTAC technology to combat stress hormone receptor activation2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors Open access
Mahshid Gazorpak, Karina M. Hugentobler, Dominique Paul, Pierre‐Luc Germain, Kei Matthis, Remo Rudolf, +11 more
0citations -
Engineering brain-penetrant PROTACs: Bridging molecular design and CNS delivery2026 Advanced Drug Delivery Reviews review Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors Open access
Xinuo Li, Jinran Li, Yuan Sun, Tingting Yao, Sai Liu, Haotian Li, +16 more
7citations -
Engineering brain-penetrant PROTACs: Bridging molecular design and CNS delivery2026 Advanced Drug Delivery Reviews article Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors Open access
Xinuo Li, Jinran Li, Yuan Sun, Tingting Yao, Sai Liu, Haotian Li, +14 more
0citations -
Sequential deregulation of histone marks, chromatin accessibility and gene expression in response to PROTAC-induced degradation of ASH2L2023 Scientific Reports article Biochemistry, Genetics and Molecular Biology Genomics and Chromatin Dynamics Open access
Mirna Barsoum, Roksaneh Sayadi-Boroujeni, Alexander T. Stenzel, Philip Bussmann, Juliane Lüscher‐Firzlaff, Bernhard Lüscher
5citations -
Sequential deregulation of histone marks, chromatin accessibility and gene expression in response to PROTAC-induced degradation of ASH2L2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Genomics and Chromatin Dynamics Open access
Mirna Barsoum, Roksaneh Sayadi-Boroujeni, Alexander T. Stenzel, Philip Bussmann, Juliane Lüscher‐Firzlaff, Bernhard Lüscher
0citations -
Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes2023 Journal of Medicinal Chemistry article Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors Open access cited by 3 patents
Ingo Volker Hartung, Joachim Rudolph, Mary M. Mader, Monique P. C. Mulder, Paul Workman
100citations -
Leveraging Targeted Protein Degradation for G Protein-Coupled Receptors: The Development of CCR2 Molecular Degraders2025 Journal of Medicinal Chemistry article Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors Open access
Khaled Essa, Natalia V. Ortiz Zacarı́as, Sascha Röth, Bo‐Tao Xin, Sabine de Winter, Cas van der Horst, +10 more
2citations -
Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization2025 Medicinal Research Reviews article Medicine Drug Transport and Resistance Mechanisms Open access
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es
2citations -
99 Targeted complement inhibition using engineered bispecific antibodies that bind local antigens and endogenous complement regulators as a novel therapeutic approach2023 Immunobiology article Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors
Leendert Adrianus Trouw, Leoni Abendstein, Kyra A. Gelderman, Paul W.H.I. Parren, Thomas Harry Sharp, Fleur S. van de Bovenkamp
0citations
24 results