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Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation2023 Proceedings of the National Academy of Sciences article Medicine Systemic Lupus Erythematosus Research Open access cited by 3 patents
Douwe J. Dijkstra, Fleur S. van de Bovenkamp, Leoni Abendstein, Rob Zuijderduijn, Jos Pool, Cynthia S. M. Kramer, +10 more
18citations -
44 Bi-specific antibodies targeting C1q and a tumor antigen activate the complement system independent of C1q-Fc interactions2023 Immunobiology article Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors
Els van der Meijden, Frank J M Beurskens, Leendert Adrianus Trouw
0citations -
Anti‐C1q autoantibodies may not serve as an adequate biomarker for lung manifestations in systemic sclerosis: a single‐centre, cross‐sectional study2021 British Journal of Dermatology article Medicine Systemic Sclerosis and Related Diseases Open access
Douwe J. Dijkstra, Sophie I E Liem, Nina Marijn van Leeuwen, Cynthia M. Fehres, Jeska Kirsten De Vries-Bouwstra, Leendert Adrianus Trouw
1citations -
Circulating C1q levels in health and disease, more than just a biomarker2021 Molecular Immunology article Immunology and Microbiology Complement system in diseases Open access cited by 3 patents
Fleur S. van de Bovenkamp, Douwe J. Dijkstra, Cees van Kooten, Kyra A. Gelderman, Leendert Adrianus Trouw
55citations -
C1q-targeting bispecific antibodies bypass Fc to trigger complement activation and receptor clustering agonism2026 Molecular Immunology article Medicine Monoclonal and Polyclonal Antibodies Research Open access
Douwe J. Dijkstra, Marfa Blanter, Els van der Meijden, Rick J. Groenland, Clifford Rodriguez, Boris Bleijlevens, +2 more
0citations -
Inverse correlation between serum complement component C1q levels and whole blood type‐1 interferon signature in active tuberculosis and QuantiFERON‐positive uveitis: implications for diagnosis2020 Clinical & Translational Immunology article Medicine Tuberculosis Research and Epidemiology Open access
Benjamin Schrijver, Douwe J. Dijkstra, Nicole V. Borggreven, Rina La Distia Nora, Erika Huijser, Marjan A. Versnel, +4 more
9citations -
Hematopoietic Stem Cell Transplantation for C1q Deficiency: A Study on Behalf of the EBMT Inborn Errors Working Party2024 Journal of Clinical Immunology article Immunology and Microbiology Immunodeficiency and Autoimmune Disorders Open access
Helena Buso, Etai Adam, Peter D. Arkwright, Sagar Bhattad, Amir Ali Hamidieh, Maryam Behfar, +23 more
9citations -
C1q binding to surface-bound IgG is stabilized by C1r 2 s 2 proteases2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Complement system in diseases Open access
Seline A. Zwarthoff, Kevin Widmer, Annemarie Kuipers, Jürgen Strasser, Maartje Ruyken, Piet C. Aerts, +12 more
1citations -
C1q binding to surface-bound IgG is stabilized by C1r 2 s 2 proteases2021 Proceedings of the National Academy of Sciences article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent
Seline A. Zwarthoff, Kevin Widmer, Annemarie Kuipers, Jürgen Strasser, Maartje Ruyken, Piet C. Aerts, +13 more
62citations -
C1q-mediated steric hindrance limits FcγR contribution to antibody-driven phagocytosis by human neutrophils2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Monoclonal and Polyclonal Antibodies Research Open access
Max L.B. Grönloh, Lisanne de Vor, Seline A. Zwarthoff, Jana Venema, Rosemieke Smits, Stan Baijens, +7 more
0citations -
Serum complement component C1q levels in Quantiferon positive uveitis: improved stratification of high versus low risk active tuberculosis?2020 Investigative Ophthalmology & Visual Science article Medicine Ocular Diseases and Behçet’s Syndrome Open access
Benjamin Schrijver, Douwe J. Dijkstra, Nicole V. Borggreven, Rina La Distia Nora, Martin P. van Hagen, Simone A. Joosten, +2 more
0citations -
Fc Galactosylation Promotes Hexamerization of Human IgG1, Leading to Enhanced Classical Complement Activation2021 The Journal of Immunology article Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 1 patent
Thijs L. J. van Osch, Jan Nouta, Ninotska I. L. Derksen, Gerard van Mierlo, C. Ellen van der Schoot, Manfred Wuhrer, +2 more
88citations -
Systemic and local complement activation in peritoneal dialysis patients via conceivably distinct pathways2023 Peritoneal Dialysis International article Immunology and Microbiology Complement system in diseases Open access
Bernardo Faria, Mariana Gaya da Costa, Stefan P. Berger, Carla Lima, Cátia Pêgo, Jacob van den Born, +5 more
1citations -
DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation2024 Journal of the American Chemical Society article Immunology and Microbiology Complement system in diseases Open access cited by 2 patents
Leoni Abendstein, Willem E. M. Noteborn, Luc S. Veenman, Douwe J. Dijkstra, Fleur S. van de Bovenkamp, Leendert Adrianus Trouw, +1 more
16citations -
Alternative pathway–mediated tubular complement activation in human proteinuric kidney diseases: a proof-of-concept study2025 Clinical Kidney Journal article Immunology and Microbiology Complement system in diseases Open access
Firas Farisi Alkaff, Rosa G. M. Lammerts, Gesa Tiller, Marius Christianus van den Heuvel, Ingeborg M. Bajema, Mohamed R. Daha, +2 more
5citations