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Oral Monotherapy with Iptacopan, a Proximal Complement Inhibitor of Factor B, Has Superior Efficacy to Intravenous Terminal Complement Inhibition with Standard of Care Eculizumab or Ravulizumab and Favorable Safety in Patients with Paroxysmal Nocturnal Hemoglobinuria and Residual Anemia: Results from the Randomized, Active-Comparator-Controlled, Open-Label, Multicenter, Phase III Apply-PNH Study
Régis Peffault de Latour, Alexander Roeth, Austin Gladston Kulasekararaj, Phillip Scheinberg, Yasutaka Ueda, Carlos M. de Castro, +15 more
23citations -
The role of complement activation in autoimmune liver disease2020 Autoimmunity Reviews article Medicine Liver Diseases and Immunity Open access cited by 1 patent
Maaike Biewenga, Arantza Fariña Sarasqueta, Maarten E. Tushuizen, Eveline S. M. de Jonge‐Muller, Bart van Hoek, Leendert Adrianus Trouw
35citations -
Atypical Hemolytic Uremic Syndrome in Children and Adults With the Hot Spot C3 Gene Variant p.Arg161Trp2026 Kidney International Reports article Immunology and Microbiology Complement system in diseases Open access
Lieke ter Steeg, Romy N. Bouwmeester, Mendy ter Avest, Fréderike J. Bemelman, Antonia H. M. Bouts, Obbo W Bredewold, +18 more
0citations -
Weak Expression of Terminal Complement in Active Antibody-Mediated Rejection of the Kidney2022 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access
Gesa Tiller, Rosa G. M. Lammerts, Jessy J. Karijosemito, Firas Farisi Alkaff, Arjan Diepstra, Robert A. Pol, +7 more
12citations -
C1q-targeting bispecific antibodies bypass Fc to trigger complement activation and receptor clustering agonism2026 Molecular Immunology article Medicine Monoclonal and Polyclonal Antibodies Research Open access
Douwe J. Dijkstra, Marfa Blanter, Els van der Meijden, Rick J. Groenland, Clifford Rodriguez, Boris Bleijlevens, +2 more
0citations -
Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune-stromal interactions as a therapeutic target2026 Cell stem cell article Medicine Myeloproliferative Neoplasms: Diagnosis and Treatment Open access
Bérénice Dugué, Pia Wanner, Mayra L. Ruiz Tejada Segura, Mohamed Saad, Lucas Greven, Katrin Götz, +33 more
2citations -
Fc Galactosylation Promotes Hexamerization of Human IgG1, Leading to Enhanced Classical Complement Activation2021 The Journal of Immunology article Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 1 patent
Thijs L. J. van Osch, Jan Nouta, Ninotska I. L. Derksen, Gerard van Mierlo, C. Ellen van der Schoot, Manfred Wuhrer, +2 more
88citations -
Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis2022 Clinical Journal of the American Society of Nephrology article Medicine Renal Diseases and Glomerulopathies Open access cited by 1 patent
Hannah J. Lomax-Browne, Nicholas Medjeral‐Thomas, Sean J. Barbour, Jack Gisby, Heedeok Han, Andrew S. Bomback, +19 more
52citations -
The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP222023 Current Research in Neurobiology article Neuroscience Hereditary Neurological Disorders Open access
Iliana Michailidou, Jeroen P. Vreijling, Matthijs Rumpf, Maarten Loos, Bastijn Koopmans, Nina Vlek, +6 more
8citations -
Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells2022 European Journal of Immunology article Immunology and Microbiology Complement system in diseases Open access
Mieke F. van Essen, Nicole Schlagwein, Elisa M.P. van den Hoven, Daniëlle J. van Gijlswijk‐Janssen, Rosalie Lubbers, Ramon M. van den Bos, +4 more
8citations -
Clinical Outcomes of Patients with C3G or IC-MPGN Treated with the Factor D Inhibitor Danicopan: Final Results from Two Phase 2 Studies2022 American Journal of Nephrology article Immunology and Microbiology Complement system in diseases Open access
Carla Nester, Gerald B. Appel, Andrew S. Bomback, Koenraad Peter Bouman, H. Terence Cook, Erica Daina, +14 more
70citations -
Platelets interact with CD169+ macrophages and cDC1 and enhance liposome-induced CD8+ T cell responses2023 Frontiers in Immunology article Immunology and Microbiology Immunotherapy and Immune Responses Open access
Joanna Aleksandra Grabowska, Valentine Léopold, Katarzyna Olesek, Maarten K. Nijen Twilhaar, Alsya J. Affandi, Mieke C. Brouwer, +7 more
10citations -
Activated Microglia-Derived Extracellular Vesicles Elicit a Pro-Inflammatory Astrocytic Response via Cargo-Dependent Mechanisms2026 Biomolecules article Biochemistry, Genetics and Molecular Biology Extracellular vesicles in disease Open access
Miriam Scheld, Nadine Jülich, Katharina Vöhringer, Adib Zendedel, Cordian Beyer, Sebastian Kant, +2 more
9citations -
Replication of 10 novel loci involved in human plasma protein N-glycosylation using MALDI-MS and UHPLC-FD data2026 Glycobiology article Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access
Anna N. Timoshchuk, Annemieke Naber, Roderick C. Slieker, Anna G. Soplenkova, Denis E. Maslov, Nadezhda A. Potapova, +8 more
1citations -
Eine chemisch‐proteomische Strategie identifiziert Inhibitoren der Lipoat‐Wiederverwertung in Bakterien und Parasiten2023 Angewandte Chemie article Biochemistry, Genetics and Molecular Biology Biochemical Acid Research Studies Open access
Jan‐Niklas Dienemann, Shuyu Chen, Manuel Hitzenberger, Montana L. Sievert, Stephan M. Hacker, Sean T. Prigge, +3 more
0citations