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Circulating levels of endogenous complement inhibitors correlate inversely with complement consumption in systemic lupus erythematosus2024 European Journal of Immunology article Medicine Systemic Lupus Erythematosus Research Open access
Stef van der Meulen, Rory Caitlin Monahan, Kyra A. Gelderman, Cees van Kooten, Y K Onno Teng, Tom W. J. Huizinga, +2 more
3citations -
MDS-278 Substantial Increases in Paroxysmal Nocturnal Hemoglobinuria (PNH) Red Blood Cell Clone Size With Oral Iptacopan Monotherapy Confirms Control of Hemolysis in Complement Inhibitor-Naive PNH Patients2023 Clinical Lymphoma Myeloma & Leukemia conference-abstract Immunology and Microbiology Complement system in diseases Open access
Régis Peffault de Latour, Bing Han, Jaroslaw Pawel Maciejewski, Yasutaka Ueda, Rong Fu, Li Zhang, +15 more
1citations -
Oral Monotherapy with Iptacopan, a Proximal Complement Inhibitor of Factor B, Has Superior Efficacy to Intravenous Terminal Complement Inhibition with Standard of Care Eculizumab or Ravulizumab and Favorable Safety in Patients with Paroxysmal Nocturnal Hemoglobinuria and Residual Anemia: Results from the Randomized, Active-Comparator-Controlled, Open-Label, Multicenter, Phase III Apply-PNH Study
Régis Peffault de Latour, Alexander Roeth, Austin Gladston Kulasekararaj, Phillip Scheinberg, Yasutaka Ueda, Carlos M. de Castro, +15 more
23citations -
The complement alternative pathway in paroxysmal nocturnal hemoglobinuria: From a pathogenic mechanism to a therapeutic target2022 Immunological Reviews review Immunology and Microbiology Complement system in diseases Open access
Antonio Maria Risitano, Camilla Frieri, Eleonora Urciuoli, Luana Marano
52citations -
Thrombospondin-1 inhibits alternative complement pathway activation in vasculitis synergistically to factor H2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Complement system in diseases Open access
Swagata Konwar, Sophie Schroda, Jessika Kleindienst, Eva L. Decker, Martin Pohl, Barbara Zieger, +10 more
0citations -
The role of complement activation in autoimmune liver disease2020 Autoimmunity Reviews article Medicine Liver Diseases and Immunity Open access cited by 1 patent
Maaike Biewenga, Arantza Fariña Sarasqueta, Maarten E. Tushuizen, Eveline S. M. de Jonge‐Muller, Bart van Hoek, Leendert Adrianus Trouw
35citations -
Atypical Hemolytic Uremic Syndrome in Children and Adults With the Hot Spot C3 Gene Variant p.Arg161Trp2026 Kidney International Reports article Immunology and Microbiology Complement system in diseases Open access
Lieke ter Steeg, Romy N. Bouwmeester, Mendy ter Avest, Fréderike J. Bemelman, Antonia H. M. Bouts, Obbo W Bredewold, +18 more
0citations -
Weak Expression of Terminal Complement in Active Antibody-Mediated Rejection of the Kidney2022 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access
Gesa Tiller, Rosa G. M. Lammerts, Jessy J. Karijosemito, Firas Farisi Alkaff, Arjan Diepstra, Robert A. Pol, +7 more
12citations -
C1q-targeting bispecific antibodies bypass Fc to trigger complement activation and receptor clustering agonism2026 Molecular Immunology article Medicine Monoclonal and Polyclonal Antibodies Research Open access
Douwe J. Dijkstra, Marfa Blanter, Els van der Meijden, Rick J. Groenland, Clifford Rodriguez, Boris Bleijlevens, +2 more
0citations -
Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune-stromal interactions as a therapeutic target2026 Cell stem cell article Medicine Myeloproliferative Neoplasms: Diagnosis and Treatment Open access
Bérénice Dugué, Pia Wanner, Mayra L. Ruiz Tejada Segura, Mohamed Saad, Lucas Greven, Katrin Götz, +33 more
2citations -
Real-World Clinical Outcomes for Complement Inhibitor Experienced and Naïve Paroxysmal Nocturnal Hemoglobinuria Patients Prescribed Pegcetacoplan in Europe and Canada2024 Blood conference-abstract Immunology and Microbiology Complement system in diseases Open access
Jens Panse, Juan Carlos Vallejo Llamas, Koo Wilson, Zalmaï Hakimi, Barbara Czech, Sam Williamson, +4 more
1citations -
Apply-PNH: Analysis of complement pathway biomarkers provides evidence for pharmacodynamic response in PNH patients who receive oral iptacopan monotherapy versus continuing anti-C5 therapy2025 Blood conference-abstract Immunology and Microbiology Complement system in diseases Open access
Régis Peffault de Latour, Richard Kelly, Austin Gladston Kulasekararaj, Alexander Röth, Phillip Scheinberg, Yasutaka Ueda, +4 more
0citations -
Fc Galactosylation Promotes Hexamerization of Human IgG1, Leading to Enhanced Classical Complement Activation2021 The Journal of Immunology article Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 1 patent
Thijs L. J. van Osch, Jan Nouta, Ninotska I. L. Derksen, Gerard van Mierlo, C. Ellen van der Schoot, Manfred Wuhrer, +2 more
88citations -
Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis2022 Clinical Journal of the American Society of Nephrology article Medicine Renal Diseases and Glomerulopathies Open access cited by 1 patent
Hannah J. Lomax-Browne, Nicholas Medjeral‐Thomas, Sean J. Barbour, Jack Gisby, Heedeok Han, Andrew S. Bomback, +19 more
52citations -
CT-286: Results of the PEGASUS Phase 3 Randomized Trial Demonstrating Superiority of the C3 Inhibitor, Pegcetacoplan, Compared to Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria2020 Clinical Lymphoma Myeloma & Leukemia conference-abstract Immunology and Microbiology Complement system in diseases
Peter Hillmen, Jeff Szer, Ilene Ceil Weitz, Alexander Röth, Britta Höchsmann, Jens Panse, +10 more
1citations -
The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP222023 Current Research in Neurobiology article Neuroscience Hereditary Neurological Disorders Open access
Iliana Michailidou, Jeroen P. Vreijling, Matthijs Rumpf, Maarten Loos, Bastijn Koopmans, Nina Vlek, +6 more
8citations -
Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells2022 European Journal of Immunology article Immunology and Microbiology Complement system in diseases Open access
Mieke F. van Essen, Nicole Schlagwein, Elisa M.P. van den Hoven, Daniëlle J. van Gijlswijk‐Janssen, Rosalie Lubbers, Ramon M. van den Bos, +4 more
8citations