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Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis2020 Journal of Hepatology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Antje Mohs, Tobias Otto, Kai Markus Schneider, Mona Peltzer, Mark V. Boekschoten, Christian H. Holland, +7 more
142citations -
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes2021 Cell Biology and Toxicology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Lukas S. Wijaya, Carina Rau, Theresa Braun, Serif Marangoz, Vincent Spegg, Matthijs Vlasveld, +8 more
15citations -
NRF2/Itaconate Axis Regulates Metabolism and Inflammatory Properties of T Cells in Children with JIA2022 Antioxidants article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Anandhi Rajendiran, Sudheendra Hebbar Subramanyam, Patricia Klemm, Vera Jankowski, Jorg van Loosdregt, Sebastiaan J. Vastert, +4 more
16citations -
Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models2022 Archives of Toxicology article Biochemistry, Genetics and Molecular Biology Carcinogens and Genotoxicity Assessment Open access
Liliana Capinha, Yaran Zhang, Anna‐Katharina Holzer, Anna‐Katharina Ückert, Melinda Zana, Giada Carta, +8 more
12citations -
Keap1 Deletion Rescues Cell Death Associated With Gpx4 Loss in Hepatocytes During Acute Liver Injury2025 Liver International article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Leticia Colyn, Julia Grube, Chaochao Wang, Mark Kühnel, Jörg Reinders, Karolina Edlund, +4 more
6citations -
p62/SQSTM1-KEAP1 complex prevents clearance of ubiquitinated Z alpha-1 antitrypsin and aggravates liver proteotoxicity2026 Journal of Biological Chemistry article Biochemistry, Genetics and Molecular Biology Endoplasmic Reticulum Stress and Disease Open access
Nunzia Pastore, Sergio Attanasio, Francesco Annunziata, Claudia D’Agostino, Veronica Maffia, Teresa Giuliano, +12 more
0citations -
Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction2020 Nature Communications article Biochemistry, Genetics and Molecular Biology Cancer-related molecular mechanisms research Open access
Dorotée Julia Trembinski, Diewertje I. Bink, Kosta Theodorou, Janina Sommer, Ariane Fischer, Anke S. van Bergen, +26 more
106citations -
Adverse Effects of Oxidative Stress on Bone and Vasculature in Corticosteroid-Associated Osteonecrosis: Potential Role of Nuclear Factor Erythroid 2-Related Factor 2 in Cytoprotection
Yusuke Kubo, Wolf Drescher, Athanassios Fragoulis, Mersedeh Tohidnezhad, Holger Jahr, Matthias Gatz, +5 more
38citations -
Betaine ameliorates doxorubicin‐induced cardiomyopathy by inhibiting oxidative stress, inflammation, and fibrosis through the modulation of AMPK /Nrf2/ TGF ‐β expression
Sumeet Kumar Singh, Poonam Yadav, Sampat Singh Tanwar, Abhishek Sherawat, Amit Khurana, Jasvinder Singh Bhatti, +1 more
24citations -
Upregulation of CCL7, CCL20, CXCL2, IL-1β, IL-6 and MMP-9 in Skin Samples of PCB Exposed Individuals—A Preliminary Study2021 International Journal of Environmental Research and Public Health article Environmental Science Toxic Organic Pollutants Impact Open access
Marike M. Leijs, Katharina Fietkau, Hans Friedrich Merk, Thomas Schettgen, Thomas Kraus, André Esser
6citations -
Computational modelling identifies primary mediators of crosstalk between DNA damage and oxidative stress responses2025 PLoS Computational Biology article Biochemistry, Genetics and Molecular Biology Genomics, phytochemicals, and oxidative stress Open access
Elsje J Burgers, Raju P. Sharma, Carl Joshua Eugenio, Muriel M. Heldring, Lukas S. Wijaya, Bob van de Water, +1 more
3citations -
Possible Association of Nrf2/ARE and NFκB Response to Osteoblast Function in Spheroid Culture Induced by Low-Intensity Pulsed Ultrasound (LIPUS)2025 Ultrasound in Medicine & Biology article Biochemistry, Genetics and Molecular Biology Bone Metabolism and Diseases Open access
Yusuke Kubo, Anna Theresa Tangarife Bodensiek, Sebastian Lippross, Marek Weiler, Nina Reinhardt, Matias de la Fuente, +11 more
0citations -
Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia2022 Stem Cell Reports article Neuroscience Neuroinflammation and Neurodegeneration Mechanisms Open access
Boyd Kenkhuis, Michelle van Eekeren, David A. Parfitt, Yavuz Ariyürek, Poulomi Banerjee, Josef Priller, +2 more
70citations -
Biophysical Modulation of the Mitochondrial Metabolism and Redox in Bone Homeostasis and Osteoporosis: How Biophysics Converts into Bioenergetics2021 Antioxidants article Biochemistry, Genetics and Molecular Biology Bone Metabolism and Diseases Open access
Feng‐Sheng Wang, Re‐Wen Wu, Yushan Chen, Jih‐Yang Ko, Holger Jahr, Wei‐Shiung Lian
62citations -
The interplay between tauopathy and aging through interruption of UPR/Nrf2/autophagy crosstalk in the Alzheimer’s disease transgenic experimental models2023 International Journal of Neuroscience article Medicine Alzheimer's disease research and treatments
Javad Amini, Naser Sanchooli, Mohammad-Hossein Milajerdi, Maryam Baeeri, Mohammad Haddadi, Nima Sanadgol
19citations -
The integrated stress response‐related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability2024 Liver International article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Matthijs Vlasveld, Giulia Callegaro, Ciaran P. Fisher, Julie A. Eakins, PAUL A. WALKER, Samantha Lok, +6 more
7citations -
Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models2025 Toxicology in Vitro article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Tamara Meijer, Bas ter Braak, Liesanne Wolters, Steven J. Kunnen, Barira Islam, Ilinca Suciu, +8 more
3citations -
Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells2023 Journal of Chemical Information and Modeling article Computer Science Computational Drug Discovery Methods Open access
Olivier J. M. Béquignon, José Carlos Gómez-Tamayo, Eelke Bart Lenselink, Steven Wink, Steven W. Hiemstra, Chi Chung Lam, +6 more
3citations