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Tandem Substitutions in Somatic Hypermutation2022 Frontiers in Immunology article Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Julieta Sepúlveda-Yáñez, Diego Álvarez-Saravia, Bas Pilzecker, Pauline A. van Schouwenburg, Mirjam van der Burg, Hendrik Veelken, +3 more
4citations -
Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation2023 Frontiers in Immunology article Immunology and Microbiology T-cell and B-cell Immunology Open access
Aldo Spanjaard, Maria Stratigopoulou, Daniël de Groot, Muhammad Assad Aslam, Paul C.M. van den Berk, Chantal Stappenbelt, +7 more
2citations -
Tandem Substitutions in Somatic Hypermutation2021 Blood conference-abstract Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Marvyn T. Koning, Julieta Sepúlveda-Yáñez, Diego Álvarez-Saravia, Bas Pilzecker, Pauline A. van Schouwenburg, Mirjam van der Burg, +3 more
1citations -
Somatic hypermutation-mediated paratope flexibility improves the cross-reactivity of human malaria antibodies2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Malaria Research and Control Open access
Rajagopal Murugan, Anton Hanke, Opeyemi Ernest Oludada, Giulia Costa, Yevel Flores-García, Ghulam Mustafa, +9 more
0citations -
High microbiota reactivity of adult human intestinal IgA requires somatic mutations2020 The Journal of Experimental Medicine article Biochemistry, Genetics and Molecular Biology Gut microbiota and health Open access
Johanna Kabbert, Julia Benckert, Tim Rollenske, Thomas C. A. Hitch, Thomas Clavel, Vuk Cerovic, +2 more
91citations -
Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load2021 Arthritis Research & Therapy article Medicine Rheumatoid Arthritis Research and Therapies Open access
Sanne Reijm, Theresa Kissel, Gerrie Stoeken‐Rijsbergen, Linda M. Slot, Corrie M. Wortel, Hugo J. van Dooren, +11 more
23citations -
Causative mechanisms and clinical impact of immunoglobulin deficiencies in ataxia telangiectasia2024 Journal of Allergy and Clinical Immunology article Immunology and Microbiology Immunodeficiency and Autoimmune Disorders Open access
Sanami Takada, Thomas J. Weitering, Nienke J.H. van Os, Likun Du, Ingrid Pico‐Knijnenburg, Thomas B. Kuipers, +6 more
18citations -
B-cell immunodeficiency associated with polynucleotide kinase 3′-phosphatase (PNKP) deficiency2025 Journal of Allergy and Clinical Immunology Global article Immunology and Microbiology Immunodeficiency and Autoimmune Disorders Open access
Sanami Takada, Tsubasa Okano, Kay Tanita, Kaima Tsukada, Masato Watanabe, Atsushi Hijikata, +14 more
0citations -
Multi-omic profiling of human thymic B cells reveals intrathymic Ig-class switching and differentiation into multiple memory B cell subsets2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology T-cell and B-cell Immunology Open access
Martijn Cordes, Erik B. van den Akker, Janine E. Melsen, Saskia Bunschuh, Aline Zbinden, Sandra de Bruin-Versteeg, +8 more
0citations -
Integration of Mutational Signature Analysis with 3D Chromatin Data Unveils Differential AID-Related Mutagenesis in Indolent Lymphomas2021 International Journal of Molecular Sciences article Medicine Lymphoma Diagnosis and Treatment Open access
Julieta Sepúlveda-Yáñez, Diego Álvarez-Saravia, José Fernández-Goycoolea, Jacqueline Aldridge, Cornelis A.M. van Bergen, Ward F.M. Posthuma, +3 more
2citations -
Targeting autoreactive B cells in rheumatoid arthritis through MHC class I-presented BCR-derived neo-epitopes2026 Journal of Autoimmunity article Biochemistry, Genetics and Molecular Biology vaccines and immunoinformatics approaches Open access
Renee van de Wetering, Arieke S. B. Kampstra, Michel G.D. Kester, Rayman T.N. Tjokrodirijo, Arnoud H. de Ru, Peter A. van Veelen, +3 more
0citations -
Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation2022 Science Advances article Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access
Theresa Kissel, Changrong Ge, Lise Hafkenscheid, Joanneke C. Kwekkeboom, Linda M. Slot, Marco Cavallari, +18 more
77citations -
A Comparison of Immunoglobulin Variable Region N-Linked Glycosylation in Healthy Donors, Autoimmune Disease and Lymphoma2020 Frontiers in Immunology article Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access cited by 1 patent
Esther M. Vletter, Marvyn T. Koning, Hans Ulrich Scherer, Hendrik Veelken, René E. M. Toes
37citations -
Population matched (PM) germline allelic variants of immunoglobulin ( IG ) loci: New pmIG database to better understand IG repertoire and selection processes in disease and vaccination2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology vaccines and immunoinformatics approaches Open access
Indu Khatri, Magdalena A. Berkowska, Erik B. van den Akker, Cristina Teodósio, Marcel J. T. Reinders, Jacques J. M. van Dongen
14citations -
Benchmarking computational methods for B-cell receptor reconstruction from single-cell RNA-seq data2022 NAR Genomics and Bioinformatics article Biochemistry, Genetics and Molecular Biology Single-cell and spatial transcriptomics Open access
Tommaso Andreani, Linda M. Slot, Samuel Gabillard, Carsten Strübing, Yaligara Veeranagouda, Aleida M. Bakker, +5 more
14citations -
Deciphering imprints of impaired memory B-cell maturation in germinal centers of three patients with common variable immunodeficiency2022 Frontiers in Immunology article Immunology and Microbiology Immunodeficiency and Autoimmune Disorders Open access
Pauline A. van Schouwenburg, Susanne Unger, Kathryn J. Payne, Fabian M. P. Kaiser, Ingrid Pico‐Knijnenburg, Jens Pfeiffer, +8 more
11citations -
RNA binding proteins control the G 2 -M checkpoint of the germinal center B cell2025 Science Immunology article Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Fiamma Salerno, Alex J. Whale, Louise S. Matheson, Davide Maria Vespasiani, William S. Foster, Twm J. Mitchell, +8 more
11citations -
Plasma cells are not restricted to the CD27+ phenotype: characterization of CD27-CD43+ antibody-secreting cells2023 Frontiers in Immunology article Immunology and Microbiology T-cell and B-cell Immunology Open access
Kris Covens, Bert Verbinnen, Britt G. de Jong, Leen Moens, Greet Wuyts, Geert R. Verheyen, +11 more
4citations