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Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays101citations
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Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning2021 Molecular Therapy article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access cited by 1 patent
Adrian Schwarzer, Steven Roger Talbot, Anton Selich, Michael Alexander Morgan, Juliane Wilhelmine Schott, Oliver Dittrich‐Breiholz, +11 more
51citations -
Peak transgene expression after intramuscular immunization of mice with adenovirus 26-based vector vaccines correlates with transgene-specific adaptive immune responses2024 PLoS ONE article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access
Sonia Marquez-Martinez, Nadine C. Salisch, Jan Serroyen, Roland C. Zahn, Selina Khan
5citations -
The modular pYT vector series employed for chromosomal gene integration and expression to produce carbazoles and glycolipids in P. putida2022 FEMS Microbes article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Robin Weihmann, Sonja Kubicki, Nora Lisa Bitzenhofer, Andreas Domröse, Isabel Bator, Lisa-Marie Kirschen, +8 more
6citations -
Influence of AAV vector tropism on long-term expression and Fc-γ receptor binding of an antibody targeting SARS-CoV-22024 Communications Biology article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access
Jannik T. Wagner, Sandra M. Müller-Schmucker, Wenjun Wang, Philipp Arnold, Nadja Uhlig, Leila Issmail, +14 more
3citations -
A host-vector toolbox for improved secretory protein overproduction in Bacillus subtilis2022 Applied Microbiology and Biotechnology article Biochemistry, Genetics and Molecular Biology Bacterial Genetics and Biotechnology Open access
Anna Krüger, Norma Welsch, Alexandra Dürwald, Henrike B. Brundiek, Rainer Wardenga, Henning Piascheck, +7 more
13citations -
Characterization of an immune-evading doxycycline-inducible lentiviral vector for gene therapy in the spinal cord2022 Experimental Neurology article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access
Fred de Winter, Isaac Francos-Quijorna, Emily R. Burnside, Barbara Hobo, Ruben Eggers, Stefan A. Hoyng, +5 more
4citations -
PhP.B Enhanced Adeno-Associated Virus Mediated-Expression Following Systemic Delivery or Direct Brain Administration2021 Frontiers in Bioengineering and Biotechnology article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access cited by 2 patents
Kimberly L. Pietersz, Stephan M. Pouw, Jolanda M.P. Liefhebber, Sander J. van Deventer, Gerard J.M. Martens, Pavlina S. Konstantinova, +1 more
20citations -
A Novel Branched DNA-Based Flowcytometric Method for Single-Cell Characterization of Gene Therapy Products and Expression of Therapeutic Genes2021 Frontiers in Immunology article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access
Laura García-Pérez, Marja C.J.A. van Eggermond, Elisa Maietta, Marie‐Louise van der Hoorn, Karin Pike‐Overzet, Frank J. T. Staal
8citations -
Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors2022 Biomolecules article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access
Edward S. A. van Beelen, Wouter H. van der Valk, Thijs O. Verhagen, John C.M.J. de Groot, Margot A. Madison, Wijs Shadmanfar, +5 more
12citations -
Intrastriatal Administration of AAV5-miHTT in Non-Human Primates and Rats Is Well Tolerated and Results in miHTT Transgene Expression in Key Areas of Huntington Disease Pathology2021 Brain Sciences article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access cited by 1 patent
Elisabeth A. Spronck, Astrid Vallès, Margit H. Lampen, Paula S. Montenegro-Miranda, Sonay Keskin, Liesbeth Heijink, +5 more
48citations -
Cellular uptake of modified mRNA occurs via caveolae-mediated endocytosis, yielding high protein expression in slow-dividing cells2023 Molecular Therapy — Nucleic Acids article Biochemistry, Genetics and Molecular Biology RNA Interference and Gene Delivery Open access
Claudia Del Toro Runzer, Shivesh Anand, Carlos Mota, Lorenzo Moroni, Christian Plank, Martijn van Griensven, +1 more
19citations -
Conventional and Tropism-Modified High-Capacity Adenoviral Vectors Exhibit Similar Transduction Profiles in Human iPSC-Derived Retinal Organoids2024 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access
Andrew J. McDonald, Carmen Gallego, Charlotte A. Andriessen, M A Orlova, Manuel A.F.V. Gonçalves, Jan Wijnholds
8citations -
Novel adenovirus vaccine vectors lacking thrombosis-associated interactions with platelet factor 42025 iScience article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access
Erwan Sallard, Daniel Pembaur, Matías Ciancaglini, Lucie Manov-Bouard, Denice Weklak, Firas Hamdan, +24 more
6citations -
Vaccines based on replication incompetent Ad26 viral vectors: Standardized template with key considerations for a risk/benefit assessment2020 Vaccine article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access cited by 2 patents
Jerome H. H. V. Custers, Denny Kim, Maarten Leyssen, Marc Gurwith, Frank L. Tomaka, James S. Robertson, +10 more
84citations -
CRISPR targeting of mmu-miR-21a through a single adeno-associated virus vector prolongs survival of glioblastoma-bearing mice2024 Molecular Therapy article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access
Lisa Nieland, Anne B. Vrijmoet, Isabelle W. Jetten, David Rufino‐Ramos, Alexandra J E M de Reus, Koen Breyne, +5 more
9citations -
Production of the High Value Pharmaceutical Target, Human Granulocyte‐Colony Stimulating Factor, in Nicotiana benthamiana Is Improved by Co‐Expression of the Transcriptional Regulator of the Unfolded Protein Response, bZIP602026 Plant Biotechnology Journal article Biochemistry, Genetics and Molecular Biology Transgenic Plants and Applications Open access
Nazgül Wagner, Konstantin Musiychuk, Stephen Tottey, Jukka Kervinen, Stephen J. Streatfield, Rainer Fischer, +1 more
0citations -
Human Adenovirus Type 26 Induced IL-6 Gene Expression in an αvβ3 Integrin- and NF-κB-Dependent Manner2022 Viruses article Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access
Davor Nestić, Ksenija Božinović, Isabela Drašković, Alen Kovačević, Jolien van den Bosch, Jelena Knežević, +3 more
9citations -
Insight to Gene Expression From Promoter Libraries With the Machine Learning Workflow Exp2Ipynb2021 Frontiers in Bioinformatics article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Ulf W. Liebal, Sebastian Köbbing, Linus Netze, Artur M. Schweidtmann, Alexander Mitsos, Lars M. Blank
11citations -
Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature2022 Neoplasia article Biochemistry, Genetics and Molecular Biology MicroRNA in disease regulation Open access
Sanne R. Martens‐de Kemp, Malgorzata A. Komor, Rosa Hegi, Anne S. Bolijn, Marianne Tijssen, Florence L. M. de Groen, +5 more
15citations