A data management system for precision medicine
PLOS Digital Health, vol. 4, pp. e0000464
Abstract
Precision, or personalised medicine has advanced requirements for medical data management systems (MedDMSs). MedDMS for precision medicine should be able to process hundreds of parameters from multiple sites, be adaptable while remaining in sync at multiple locations, real-time syncing to analytics and be compliant with international privacy legislation. This paper describes the LogiqSuite software solution, aimed to support a precision medicine solution at the patient care (LogiqCare), research (LogiqScience) and data science (LogiqAnalytics) level. LogiqSuite is certified and compliant with international medical data and privacy legislations. This paper evaluates a MedDMS in five types of use cases for precision medicine, ranging from data collection to algorithm development and from implementation to integration with real-world data. The MedDMS is evaluated in seven precision medicine data science projects in prehospital triage, cardiovascular disease, pulmonology, and oncology. The P4O2 consortium uses the MedDMS as an electronic case report form (eCRF) that allows real-time data management and analytics in long covid and pulmonary diseases. In an acute myeloid leukaemia, study data from different sources were integrated to facilitate easy descriptive analytics for various research questions. In the AIDPATH project, LogiqCare is used to process patient data, while LogiqScience is used for pseudonymous CAR-T cell production for cancer treatment. In both these oncological projects the data in LogiqAnalytics is also used to facilitate machine learning to develop new prediction models for clinical-decision support (CDS). The MedDMS is also evaluated for real-time recording of CDS data from U-Prevent for cardiovascular risk management and from the Stroke Triage App for prehospital triage. The MedDMS is discussed in relation to other solutions for privacy-by-design, integrated data stewardship and real-time data analytics in precision medicine. LogiqSuite is used for multi-centre research study data registrations and monitoring, data analytics in interdisciplinary consortia, design of new machine learning / artificial intelligence (AI) algorithms, development of new or updated prediction models, integration of care with advanced therapy production, and real-world data monitoring in using CDS tools. The integrated MedDMS application supports data management for care and research in precision medicine.
Authors 22
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John J. L. Jacobs corresponding
Affiliation as printed
Clinical Care & Research, ORTEC B.V., Zoetermeer, The Netherlands
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Affiliation as printed
Clinical Care & Research, ORTEC B.V., Zoetermeer, The Netherlands
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Affiliation as printed
Clinical Care & Research, ORTEC B.V., Zoetermeer, The Netherlands
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Affiliation as printed
Clinical Care & Research, ORTEC B.V., Zoetermeer, The Netherlands
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ORTEC (Netherlands) · Vrije Universiteit Amsterdam
Affiliation as printed
Clinical Care & Research, ORTEC B.V., Zoetermeer, The Netherlands
Faculty of Mathematics, VU, Amsterdam, The Netherlands
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Amsterdam University Medical Centers
Affiliation as printed
Department of Pulmonary Medicine, Amsterdam UMC, The Netherlands
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Vera A. M. C. Bongaerts Aachen Department of Public Health and Primary Care Public Health and Primary Care
Leiden University Medical Center
Affiliation as printed
Department of Public Health and Primary Care, LUMC, Leiden, The Netherlands
Public Health & Primary Care, and Health Campus The Hague, Leiden University Medical Center, The Hague, The Netherlands
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Amsterdam University Medical Centers
Affiliation as printed
Department of Haematology, Amsterdam UMC, The Netherlands
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Frederik Erkens Aachen Fraunhofer IPT Department Production Metrology Fraunhofer Institute for Production Technology IPT
Fraunhofer Institute for Production Technology IPT
Affiliation as printed
Fraunhofer IPT, Aachen, Germany
Department Production Metrology, Fraunhofer Institute for Production Technology IPT, Aachen, Germany
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Hovon · Erasmus MC Cancer Institute
Affiliation as printed
Dutch-Belgian Hemato-Oncology Cooperative Group Data Center–Erasmus MC Cancer Institute, Rotterdam, The Netherlands
Department of Haematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands
HOVON Foundation, Rotterdam, The Netherlands
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Simon Hort Aachen Fraunhofer IPT Adaptive Produktionssteuerung Fraunhofer Institute for Production Technology IPT
Fraunhofer Institute for Production Technology IPT
Affiliation as printed
Fraunhofer IPT, Aachen, Germany
Adaptive Produktionssteuerung, Fraunhofer Institute for Production Technology IPT, Aachen, Germany
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Affiliation as printed
University Clinic Würzburg, Germany
Medizinische Klinik und Poliklinik II, University Clinic Würzburg, Würzburg, Germany
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Hospital Clínic de Barcelona · Fundació Clínic per a la Recerca Biomèdica · Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
Affiliation as printed
Foundation for Biomedical Research, Barcelona, Spain
HSJD-Clinic Immunotherapy platform, Barcelona, Spain
Immunology department, Hospital Clinic of Barcelona, Barcelona, Spain
Fundació Clínic per a la Recerca Biomèdica—Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
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Amsterdam University Medical Centers
Affiliation as printed
Department of Pulmonary Medicine, Amsterdam UMC, The Netherlands
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Hospital Clínic de Barcelona · Fundació Clínic per a la Recerca Biomèdica · Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
Affiliation as printed
Foundation for Biomedical Research, Barcelona, Spain
Immunology department, Hospital Clinic of Barcelona, Barcelona, Spain
Fundació Clínic per a la Recerca Biomèdica—Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
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Amsterdam University Medical Centers
Affiliation as printed
Department of Haematology, Amsterdam UMC, The Netherlands
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Affiliation as printed
Advanced Centre for Biochemical Engineering, University College London, UK
Advanced Centre for Biochemical Engineering, University College London, London, United Kingdom
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Affiliation as printed
University Clinic Würzburg, Germany
Medizinische Klinik und Poliklinik II, University Clinic Würzburg, Würzburg, Germany
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Amsterdam University Medical Centers
Affiliation as printed
Department of Haematology, Amsterdam UMC, The Netherlands
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Leiden University Medical Center
Affiliation as printed
National eHealth Living Lab, LUMC, Leiden, The Netherlands
National eHealth Living Lab, Leiden, The Netherlands
Public Health & Primary Care, and Health Campus The Hague, Leiden University Medical Center, The Hague, The Netherlands
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Leiden University Medical Center
Affiliation as printed
Public Health & Primary Care, Leiden University Medical Center
Public Health & Primary Care, and Health Campus The Hague, Leiden University Medical Center, The Hague, The Netherlands
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Amsterdam University Medical Centers
Affiliation as printed
Department of Haematology, Amsterdam UMC, The Netherlands
Department of Pulmonary Medicine, Amsterdam UMC, The Netherlands
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