Epigenetics-targeted drugs: current paradigms and future challenges

• Safety and efficacy of givinostat in boys with Duchenne muscular dystrophy (EPIDYS): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

  2024 The Lancet Neurology article Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access cited by 1 patent

  136

  citations
• IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma

  2023 The Journal of Experimental Medicine article Medicine Cancer Immunotherapy and Biomarkers Open access cited by 3 patents

  80

  citations
• Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma

  2020 Hepatology article Medicine Cholangiocarcinoma and Gallbladder Cancer Studies

  66

  citations
• Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis

  2023 Annals of the Rheumatic Diseases article Medicine Osteoarthritis Treatment and Mechanisms Open access

  45

  citations
• PRMT5 inhibition induces pro‐inflammatory macrophage polarization and increased hepatic triglyceride levels without affecting atherosclerosis in mice

  2023 Journal of Cellular and Molecular Medicine article Biochemistry, Genetics and Molecular Biology Cancer-related gene regulation Open access

  15

  citations
• A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma

  2024 EBioMedicine article Medicine Bone Tumor Diagnosis and Treatments Open access

  13

  citations
• On RNA-programmable gene modulation as a versatile set of principles targeting muscular dystrophies

  2024 Molecular Therapy article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access

  7

  citations

7 results