Non‐coding RNAs to treat vascular smooth muscle cell dysfunction

British Journal of Pharmacology, vol. 182, pp. 246–280

Abstract

Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have unveiled a fascinating range of non-coding RNAs (ncRNAs) that play a pivotal role in regulating vSMC function. This review aims to provide an in-depth analysis of the mechanisms underlying vSMC dysfunction and the therapeutic potential of various ncRNAs in mitigating this dysfunction, either preventing or reversing it. We explore the intricate interplay of microRNAs, long-non-coding RNAs and circular RNAs, shedding light on their roles in regulating key signalling pathways associated with vSMC dysfunction. We also discuss the prospects and challenges associated with developing ncRNA-based therapies for this prevalent type of cardiovascular pathology. LINKED ARTICLES: This article is part of a themed issue Non-coding RNA Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v182.2/issuetoc.

Authors 5

1. Simon David Brown

   The Queen's Medical Research Institute · University of Edinburgh

   Affiliation as printed

   BHF Centre for Cardiovascular Science, Queens Medical Research Institute University of Edinburgh Edinburgh UK

   BHF Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK

2. Eftychia Klimi

   The Queen's Medical Research Institute · University of Edinburgh

   Affiliation as printed

   BHF Centre for Cardiovascular Science, Queens Medical Research Institute University of Edinburgh Edinburgh UK

   BHF Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK

3. Wilfried A.M. Bakker Aachen Batavia Biosciences B.V

   Batavia Biosciences (Netherlands)

   Affiliation as printed

   Batavia Biosciences B.V., Bioscience Park Leiden Leiden The Netherlands

   Batavia Biosciences B.V., Bioscience Park Leiden, Leiden, The Netherlands

4. Abdelaziz Beqqali

   The Queen's Medical Research Institute · University of Edinburgh

   Affiliation as printed

   BHF Centre for Cardiovascular Science, Queens Medical Research Institute University of Edinburgh Edinburgh UK

   BHF Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK

5. Andrew Howard Baker corresponding

   Maastricht University Medical Centre · Maastricht University · The Queen's Medical Research Institute · University of Edinburgh

   Affiliation as printed

   BHF Centre for Cardiovascular Science, Queens Medical Research Institute University of Edinburgh Edinburgh UK

   Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Medical Centre Maastricht The Netherlands

   BHF Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK

   Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands