Bispecific Complement Engagers for Targeted Complement Activation

• C1q-targeting bispecific antibodies bypass Fc to trigger complement activation and receptor clustering agonism

  2026 Molecular Immunology article Medicine Monoclonal and Polyclonal Antibodies Research Open access

  0

  citations
• Enhancing complement activation by therapeutic anti-tumor antibodies: Mechanisms, strategies, and engineering approaches

  2024 Seminars in Immunology article Immunology and Microbiology Complement system in diseases Open access

  18

  citations
• Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation

  2024 The Journal of Immunology article Immunology and Microbiology Complement system in diseases Open access

  5

  citations
• Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators

  2024 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent

  11

  citations
• Selection and characterization of a peptide-based complement modulator targeting C1 of the innate immune system

  2024 RSC Chemical Biology article Immunology and Microbiology Complement system in diseases Open access

  2

  citations

5 results

• C1q binding to surface-bound IgG is stabilized by C1r 2 s 2 proteases

  2021 Proceedings of the National Academy of Sciences article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent

  62

  citations

1 result