Recombinant supercharged polypeptides for safe and efficient heparin neutralization

Biomaterials Science, vol. 11, pp. 5533–5539

Abstract

studies revealed that the heparin-triggered bleeding was almost completely alleviated by K72 while a negligible toxic effect was observed. Therefore, such recombinant supercharged polypeptides might replace protamine sulfate as heparin-reversal agents.

Authors 12

1. Jianfei Tu

   Wenzhou Medical University

   Affiliation as printed

   Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Imaging Diagnostic and Interventional Minimally Invasive Institute, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, Zhejiang, China

2. Qing Liu corresponding

   Wenzhou Institute, University of Chinese Academy of Sciences

   Affiliation as printed

   Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, Zhejiang, China

3. Shengye You

   Wenzhou Institute, University of Chinese Academy of Sciences

   Affiliation as printed

   Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, Zhejiang, China

4. Zhuojun Meng

   Wenzhou Institute, University of Chinese Academy of Sciences

   Affiliation as printed

   Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, Zhejiang, China

5. Shiji Fang

   Wenzhou Medical University

   Affiliation as printed

   Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Imaging Diagnostic and Interventional Minimally Invasive Institute, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, Zhejiang, China

6. Binhong Yu

   Wenzhou Institute, University of Chinese Academy of Sciences

   Affiliation as printed

   Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, Zhejiang, China

7. Xumin Chen

   First Affiliated Hospital of Wenzhou Medical University

   Affiliation as printed

   Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang, China

8. Yu Jerry Zhou Aachen DWI - Leibniz Institute for Interactive Materials Institute of Technical and Macromolecular Chemistry

   DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University

   Affiliation as printed

   DWI - Leibniz Institute for Interactive Materials, Forckenbeckstr 50, 52056 Aachen, Germany

   Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074 Aachen, Germany

9. Chen Gang

   First Affiliated Hospital of Wenzhou Medical University

   Affiliation as printed

   Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

   Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

10. Jianliang Shen

    Wenzhou Institute, University of Chinese Academy of Sciences

    Affiliation as printed

    Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, Zhejiang, China

11. Lifei Zheng corresponding

    Wenzhou Institute, University of Chinese Academy of Sciences

    Affiliation as printed

    Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, Zhejiang, China

12. Jiansong Ji corresponding

    Wenzhou Medical University

    Affiliation as printed

    Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Imaging Diagnostic and Interventional Minimally Invasive Institute, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, Zhejiang, China