Ultra-strong bio-glue from genetically engineered polypeptides
Nature Communications, vol. 12, pp. 3613
Abstract
The development of biomedical glues is an important, yet challenging task as seemingly mutually exclusive properties need to be combined in one material, i.e. strong adhesion and adaption to remodeling processes in healing tissue. Here, we report a biocompatible and biodegradable protein-based adhesive with high adhesion strengths. The maximum strength reaches 16.5 ± 2.2 MPa on hard substrates, which is comparable to that of commercial cyanoacrylate superglue and higher than other protein-based adhesives by at least one order of magnitude. Moreover, the strong adhesion on soft tissues qualifies the adhesive as biomedical glue outperforming some commercial products. Robust mechanical properties are realized without covalent bond formation during the adhesion process. A complex consisting of cationic supercharged polypeptides and anionic aromatic surfactants with lysine to surfactant molar ratio of 1:0.9 is driven by multiple supramolecular interactions enabling such strong adhesion. We demonstrate the glue's robust performance in vitro and in vivo for cosmetic and hemostasis applications and accelerated wound healing by comparison to surgical wound closures.
Authors 23
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Harvard University · University of Groningen · Zernike Institute for Advanced Materials · Tsinghua University
Affiliation as printed
Department of Chemistry, Tsinghua University, Beijing, China
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA
Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands
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Harvard University · Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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Affiliation as printed
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada
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Affiliation as printed
Institute of Process Equipment, College of energy engineering, Zhejiang University, Hangzhou, China
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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Russian Academy of Sciences · Lomonosov Moscow State University · Semenov Institute of Chemical Physics
Affiliation as printed
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation
Physics Department, Lomonosov Moscow State University, Moscow, Russian Federation
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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University of Groningen · DWI – Leibniz Institute for Interactive Materials · Zernike Institute for Advanced Materials
Affiliation as printed
DWI - Leibniz Institute for Interactive Materials, Aachen, Germany
Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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DWI – Leibniz Institute for Interactive Materials
Affiliation as printed
DWI - Leibniz Institute for Interactive Materials, Aachen, Germany
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South Ural State University · Lomonosov Moscow State University · DWI – Leibniz Institute for Interactive Materials
Affiliation as printed
DWI - Leibniz Institute for Interactive Materials, Aachen, Germany
National Research South Ural State University, Chelyabinsk, Russian Federation
Physics Department, Lomonosov Moscow State University, Moscow, Russian Federation
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Affiliation as printed
Institute of Process Equipment, College of energy engineering, Zhejiang University, Hangzhou, China
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Affiliation as printed
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization · Tsinghua University
Affiliation as printed
Department of Chemistry, Tsinghua University, Beijing, China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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Kai Liu corresponding
Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization · Tsinghua University
Affiliation as printed
Department of Chemistry, Tsinghua University, Beijing, China. kailiu@tsinghua.edu.cn
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China. kailiu@tsinghua.edu.cn
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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