Transformative Materials for Interfacial Drug Delivery
Advanced Healthcare Materials, vol. 12, pp. e2301062
Abstract
Drug delivery systems (DDS) are designed to temporally and spatially control drug availability and activity. They assist in improving the balance between on-target therapeutic efficacy and off-target toxic side effects. DDS aid in overcoming biological barriers encountered by drug molecules upon applying them via various routes of administration. They are furthermore increasingly explored for modulating the interface between implanted (bio)medical materials and host tissue. Herein, an overview of the biological barriers and host-material interfaces encountered by DDS upon oral, intravenous, and local administration is provided, and material engineering advances at different time and space scales to exemplify how current and future DDS can contribute to improved disease treatment are highlighted.
Authors 16
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Institute for Experimental Molecular Imaging RWTH Aachen University Hospital 52074 Aachen Germany
Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Institute for Experimental Molecular Imaging RWTH Aachen University Hospital 52074 Aachen Germany
Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO<sup>ABCD</sup>) 52074 Aachen Germany
Institute for Experimental Molecular Imaging RWTH Aachen University Hospital 52074 Aachen Germany
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIOABCD) 52074 Aachen Germany
Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Institute for Experimental Molecular Imaging RWTH Aachen University Hospital 52074 Aachen Germany
Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany
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Robert Göstl Aachen
DWI – Leibniz Institute for Interactive Materials
Affiliation as printed
DWI – Leibniz Institute for Interactive Materials 52074 Aachen Germany
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Affiliation as printed
Institute of Applied Medical Engineering Helmholtz Institute Medical Faculty RWTH Aachen University 52074 Aachen Germany
Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
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Affiliation as printed
Institute of Biotechnology RWTH Aachen University 52074 Aachen Germany
Institute of Biotechnology, RWTH Aachen University, 52074 Aachen, Germany
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Affiliation as printed
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO<sup>ABCD</sup>) 52074 Aachen Germany
Institute for Computational Biomedicine – Disease Modeling RWTH Aachen University 52074 Aachen Germany
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIOABCD) 52074 Aachen Germany
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO<sup>ABCD</sup>) 52074 Aachen Germany
Helmholtz‐Institute for Biomedical Engineering Medical Faculty of RWTH Aachen University 52074 Aachen Germany
Institute for Stem Cell Biology University Hospital of RWTH Aachen 52074 Aachen Germany
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIOABCD) 52074 Aachen Germany
Helmholtz-Institute for Biomedical Engineering, Medical Faculty of RWTH Aachen University, 52074 Aachen, Germany
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Stefan Jockenhövel Aachen
Affiliation as printed
Department of Biohybrid & Medical Textiles (BioTex) AME – Institute of Applied Medical Engineering Helmholtz Institute Aachen RWTH Aachen University 52074 Aachen Germany
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Institute of Clinical Pharmacology University Hospital RWTH Aachen 52074 Aachen Germany
Institute of Clinical Pharmacology, University Hospital RWTH Aachen, 52074 Aachen, Germany
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Rafael Kramann Aachen Division of Nephrology and Clinical Immunology Institute of Experimental Medicine and Systems Biology
Affiliation as printed
Division of Nephrology and Clinical Immunology RWTH Aachen University 52074 Aachen Germany
Institute of Experimental Medicine and Systems Biology RWTH Aachen University 52074 Aachen Germany
Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52074 Aachen, Germany
Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, 52074 Aachen, Germany
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO<sup>ABCD</sup>) 52074 Aachen Germany
Department of Medicine III (Gastroenterology Metabolic diseases and Intensive Care) University Hospital RWTH Aachen 52074 Aachen Germany
Department of Medicine III (Gastroenterology, Metabolic diseases and Intensive Care), University Hospital RWTH Aachen, 52074 Aachen, Germany
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Tim H. Brümmendorf Aachen Department of Hematology Oncology Hemostaseology and Stem Cell Transplantation Department of Hematology, Oncology
Affiliation as printed
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO<sup>ABCD</sup>) 52074 Aachen Germany
Department of Hematology Oncology Hemostaseology and Stem Cell Transplantation RWTH Aachen University Medical School 52074 Aachen Germany
Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, RWTH Aachen University Medical School, 52074 Aachen, Germany
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO<sup>ABCD</sup>) 52074 Aachen Germany
Helmholtz‐Institute for Biomedical Engineering Medical Faculty of RWTH Aachen University 52074 Aachen Germany
Institute for Experimental Molecular Imaging RWTH Aachen University Hospital 52074 Aachen Germany
Helmholtz-Institute for Biomedical Engineering, Medical Faculty of RWTH Aachen University, 52074 Aachen, Germany
Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO<sup>ABCD</sup>) 52074 Aachen Germany
Helmholtz‐Institute for Biomedical Engineering Medical Faculty of RWTH Aachen University 52074 Aachen Germany
Institute for Experimental Molecular Imaging RWTH Aachen University Hospital 52074 Aachen Germany
Helmholtz-Institute for Biomedical Engineering, Medical Faculty of RWTH Aachen University, 52074 Aachen, Germany
Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany
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