Down‐regulation of human long non‐coding RNA LINC01187 is associated with nephropathies

Journal of Cellular and Molecular Medicine, vol. 27, pp. 1192–1205

Abstract

Chronic kidney diseases affect a substantial percentage of the adult population worldwide. This observation emphasizes the need for novel insights into the molecular mechanisms that control the onset and progression of renal diseases. Recent advances in genomics have uncovered a previously unanticipated link between the non-coding genome and human kidney diseases. Here we screened and analysed long non-coding RNAs (lncRNAs) previously identified in mouse kidneys by genome-wide transcriptomic analysis, for conservation in humans and differential expression in renal tissue from healthy and diseased individuals. Our data suggest that LINC01187 is strongly down-regulated in human kidney tissues of patients with diabetic nephropathy and rapidly progressive glomerulonephritis, as well as in murine models of kidney diseases, including unilateral ureteral obstruction, nephrotoxic serum-induced glomerulonephritis and ischemia/reperfusion. Interestingly, LINC01187 overexpression in human kidney cells in vitro inhibits cell death indicating an anti-apoptotic function. Collectively, these data suggest a negative association of LINC01187 expression with renal diseases implying a potential protective role.

Authors 16

1. Theodora Manolakou

   National and Kapodistrian University of Athens · Biomedical Research Foundation of the Academy of Athens

   Affiliation as printed

   Center for Basic Research Biomedical Research Foundation of the Academy of Athens Athens Greece

   Center for Clinical Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens Athens Greece

   School of Medicine National and Kapodistrian University of Athens Greece

   Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

   Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

   School of Medicine, National and Kapodistrian University of Athens, Greece

2. Valeria Kaltezioti

   Biomedical Research Foundation of the Academy of Athens

   Affiliation as printed

   Center for Basic Research Biomedical Research Foundation of the Academy of Athens Athens Greece

   Center for Clinical Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens Athens Greece

   Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

   Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

3. Niki Prakoura

   Hôpital Tenon

   Affiliation as printed

   Batiment Recherche Tenon Hospital Paris France

   Batiment Recherche, Tenon Hospital, Paris, France

4. Panagiotis Kavvadas

   Hôpital Tenon

   Affiliation as printed

   Batiment Recherche Tenon Hospital Paris France

   Batiment Recherche, Tenon Hospital, Paris, France

5. Simone Reichelt‐Wurm

   University Hospital Regensburg

   Affiliation as printed

   Department of Nephrology University Hospital Regensburg Regensburg Germany

   Department of Nephrology, University Hospital Regensburg, Regensburg, Germany

6. Harikleia Gakiopoulou

   National and Kapodistrian University of Athens

   Affiliation as printed

   1st Department of Pathology School of Medicine National & Kapodistrian University of Athens Athens Greece

   1st Department of Pathology, School of Medicine, National & Kapodistrian University of Athens, Athens, Greece

7. Miriam Banas

   University Hospital Regensburg

   Affiliation as printed

   Department of Nephrology University Hospital Regensburg Regensburg Germany

   Department of Nephrology, University Hospital Regensburg, Regensburg, Germany

8. Bernhard Banas

   University Hospital Regensburg

   Affiliation as printed

   Department of Nephrology University Hospital Regensburg Regensburg Germany

   Department of Nephrology, University Hospital Regensburg, Regensburg, Germany

9. Maja T. Lindenmeyer

   University Medical Center Hamburg-Eppendorf

   Affiliation as printed

   III. Department of Medicine University Medical Center Hamburg‐Eppendorf Hamburg Germany

   III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

10. Clemens David Cohen

    Ludwig-Maximilians-Universität München

    Affiliation as printed

    Nephrological Center Medical Clinic and Policlinic IV University Hospital of Munich Munich Germany

    Nephrological Center, Medical Clinic and Policlinic IV, University Hospital of Munich, Munich, Germany

11. Peter Boor Aachen Institute of Pathology Department of Nephrology and Immunology

    RWTH Aachen University · Universitätsklinikum Aachen

    Affiliation as printed

    Department of Nephrology and Immunology RWTH Aachen University Hospital Aachen Germany

    Institute of Pathology RWTH Aachen University Hospital Aachen Germany

    Department of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany

    Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany

12. Sonja Djudjaj Aachen Institute of Pathology

    RWTH Aachen University · Universitätsklinikum Aachen

    Affiliation as printed

    Institute of Pathology RWTH Aachen University Hospital Aachen Germany

    Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany

13. Dimitrios T. Boumpas

    National and Kapodistrian University of Athens · University General Hospital Attikon · Biomedical Research Foundation of the Academy of Athens

    Affiliation as printed

    Center for Clinical Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens Athens Greece

    Rheumatology and Clinical Immunology Unit 4th Department of Internal Medicine Attikon University Hospital Joint Rheumatology Program National and Kapodistrian University of Athens Medical School Athens Greece

    Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

    Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, Attikon University Hospital, Joint Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece

14. Christos Chatziantoniou

    Sorbonne Université · Inserm · Hôpital Tenon

    Affiliation as printed

    Batiment Recherche Tenon Hospital Paris France

    Faculty of Medicine Sorbonne University Paris France

    Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche Scientifique 1155 Tenon Hospital Paris France

    Batiment Recherche, Tenon Hospital, Paris, France

    Faculty of Medicine, Sorbonne University, Paris, France

15. ARISTIDIS S. CHARONIS corresponding

    Biomedical Research Foundation of the Academy of Athens

    Affiliation as printed

    Center for Clinical Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens Athens Greece

    University Research Institute of Maternal and Child Health and Precision Medicine Athens Greece

    Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

    University Research Institute of Maternal and Child Health and Precision Medicine, Athens, Greece

16. Panagiotis K. Politis corresponding

    Biomedical Research Foundation of the Academy of Athens

    Affiliation as printed

    Center for Basic Research Biomedical Research Foundation of the Academy of Athens Athens Greece

    Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece